Image3_SGLT2 inhibitors suppress epithelial–mesenchymal transition in podocytes under diabetic conditions via downregulating the IGF1R/PI3K pathway.JPEG by Ruixue Guo (6377939)

“…Additionally, SGLT2, IGF1R, phosphorylated PI3K, α-SMA, SNAI-1, and ZEB2 protein levels were increased in high glucose-stimulated human podocytes (HPC) and significantly decreased in dapagliflozin-treated (50 nM and 100 nM) or OSI-906-treated (inhibitor of IGF1R, 60 nM) groups. …”

Image6_SGLT2 inhibitors suppress epithelial–mesenchymal transition in podocytes under diabetic conditions via downregulating the IGF1R/PI3K pathway.TIF by Ruixue Guo (6377939)

“…Additionally, SGLT2, IGF1R, phosphorylated PI3K, α-SMA, SNAI-1, and ZEB2 protein levels were increased in high glucose-stimulated human podocytes (HPC) and significantly decreased in dapagliflozin-treated (50 nM and 100 nM) or OSI-906-treated (inhibitor of IGF1R, 60 nM) groups. …”

Image8_SGLT2 inhibitors suppress epithelial–mesenchymal transition in podocytes under diabetic conditions via downregulating the IGF1R/PI3K pathway.TIF by Ruixue Guo (6377939)

“…Additionally, SGLT2, IGF1R, phosphorylated PI3K, α-SMA, SNAI-1, and ZEB2 protein levels were increased in high glucose-stimulated human podocytes (HPC) and significantly decreased in dapagliflozin-treated (50 nM and 100 nM) or OSI-906-treated (inhibitor of IGF1R, 60 nM) groups. …”

Image9_SGLT2 inhibitors suppress epithelial–mesenchymal transition in podocytes under diabetic conditions via downregulating the IGF1R/PI3K pathway.TIF by Ruixue Guo (6377939)

“…Additionally, SGLT2, IGF1R, phosphorylated PI3K, α-SMA, SNAI-1, and ZEB2 protein levels were increased in high glucose-stimulated human podocytes (HPC) and significantly decreased in dapagliflozin-treated (50 nM and 100 nM) or OSI-906-treated (inhibitor of IGF1R, 60 nM) groups. …”

Image5_SGLT2 inhibitors suppress epithelial–mesenchymal transition in podocytes under diabetic conditions via downregulating the IGF1R/PI3K pathway.TIF by Ruixue Guo (6377939)

“…Additionally, SGLT2, IGF1R, phosphorylated PI3K, α-SMA, SNAI-1, and ZEB2 protein levels were increased in high glucose-stimulated human podocytes (HPC) and significantly decreased in dapagliflozin-treated (50 nM and 100 nM) or OSI-906-treated (inhibitor of IGF1R, 60 nM) groups. …”

Image7_SGLT2 inhibitors suppress epithelial–mesenchymal transition in podocytes under diabetic conditions via downregulating the IGF1R/PI3K pathway.TIF by Ruixue Guo (6377939)

“…Additionally, SGLT2, IGF1R, phosphorylated PI3K, α-SMA, SNAI-1, and ZEB2 protein levels were increased in high glucose-stimulated human podocytes (HPC) and significantly decreased in dapagliflozin-treated (50 nM and 100 nM) or OSI-906-treated (inhibitor of IGF1R, 60 nM) groups. …”

Image11_SGLT2 inhibitors suppress epithelial–mesenchymal transition in podocytes under diabetic conditions via downregulating the IGF1R/PI3K pathway.TIF by Ruixue Guo (6377939)

“…Additionally, SGLT2, IGF1R, phosphorylated PI3K, α-SMA, SNAI-1, and ZEB2 protein levels were increased in high glucose-stimulated human podocytes (HPC) and significantly decreased in dapagliflozin-treated (50 nM and 100 nM) or OSI-906-treated (inhibitor of IGF1R, 60 nM) groups. …”

Image10_SGLT2 inhibitors suppress epithelial–mesenchymal transition in podocytes under diabetic conditions via downregulating the IGF1R/PI3K pathway.TIF by Ruixue Guo (6377939)

“…Additionally, SGLT2, IGF1R, phosphorylated PI3K, α-SMA, SNAI-1, and ZEB2 protein levels were increased in high glucose-stimulated human podocytes (HPC) and significantly decreased in dapagliflozin-treated (50 nM and 100 nM) or OSI-906-treated (inhibitor of IGF1R, 60 nM) groups. …”

Feasibility Study of Using Gemstone Spectral Imaging (GSI) and Adaptive Statistical Iterative Reconstruction (ASIR) for Reducing Radiation and Iodine Contrast Dose in Abdominal CT... by Zheng Zhu (487587)

“…CT dose index (CTDI) values for non-enhanced, arterial phase and portal phase in group A were decreased by 49.04%, 40.51% and 40.54% compared with group B (P = 0.000), respectively. …”

Encoding in Balanced Networks: Revisiting Spike Patterns and Chaos in Stimulus-Driven Systems - Fig 7 by Guillaume Lajoie (3544997)

“…(<b>E</b>) Tempotron’s performance <i>P</i> against the cumulative inclusion of neurons where the spike times were strongly jittered (±50 milliseconds). Different lines indicate three orderings of neurons the neurons that were jittered, based on their trained readout weight <i>w</i>_<i>i</i>: (i) decreasing, (ii) increasing and (iii) random. …”

Focus group guide. by Judite Blanc (22559981)

“…A targeted investment of $30 billion could yield substantial improvements in healthcare, mental health services, and public safety—contributing to increased life expectancy, reduced mortality rates, and decreased violence.…”

Evaluating Hospital-Based Surveillance for Outbreak Detection in Bangladesh: Analysis of Healthcare Utilization Data by Birgit Nikolay (3423074)

“…</p><p>We estimated that surveillance detected 26% (95% CI 18%–33%) of severe neurological disease cases and 18% (95% CI 16%–21%) of fatal respiratory disease cases residing at 10 km distance from a surveillance hospital. Detection probabilities decreased markedly with distance. …”

Table 1_Comparative transcriptomic and molecular biology analyses to explore potential immune responses to Vibrio parahaemolyticus challenge in Eriocheir sinensis.docx by Duanduan Chen (6860495)

“…The results showed that intramuscular injection of 1.78 × 10⁶ CFU/mL of V. parahaemolyticus for 24 hours resulted in a 50% mortality rate among the experimental animals. …”

Directed Evolution of Human Heavy Chain Variable Domain (V_H) Using <i>In Vivo</i> Protein Fitness Filter by Dong-Sik Kim (113849)

“…With further screening of combinatorial framework mutation library of MG2x1, we found a consistent bias toward substitution with tryptophan at the position of 50 and 58 in V_H. …”

Survival.Raw Data.Zinc.xlsx by Kilmer Oliveira Soares (11497465)

“…Zinc treatment had minimal effects on bacterial DNA concentrations and absolute cell counts while emerge date (the date a bee emerged from the brood comb) had a significant effect with decreased bacterial concentrations and cell counts observed at later emerge dates. …”

Flow chart for inclusion and exclusion criteria. by Maleda Tefera (9025154)

“…Conversely, the likelihood of wasting decreased in children breastfeeding in their second and third year of life (AOR: 0.75; 95% CI 0.67, 0.83) and (AOR: 0.50; 95% CI 0.43, 0.60) respectively. …”

Data_Sheet_1_Exploiting the microbiota of organic and inorganic acid-treated raw poultry products to improve shelf-life.docx by Dana K. Dittoe (10649702)

“…On d 14, those treated with SBS and SBS + PAA had lower relative abundance of typical spoilage population while having a greater relative abundance of Bacillus spp. (~70 and 50% of population; ANCOM p < 0.05). …”

TGFβ1 and unfolded protein response (UPR) in calreticulin expressing hearts. by Jody Groenendyk (3149277)

“…<p>(<b>A)</b> Immnoblot analysis and quantification of TGF-β1 protein in control and Heart^CRT+ hearts. …”

Impact of Baseline GLP-1 Receptor Agonist Use on Albuminuria Reduction and Safety With Simultaneous Initiation of Finerenone and Empagliflozin in Type 2 Diabetes and Chronic Kidney... by Rajiv Agarwal (12950)

“…Corresponding results in those not using a GLP-1 RA at baseline were −56% (−62 to −50), −37% (−45 to −28), and −33% (−41 to −23), respectively. …”

Presentation_1_The Successional Changes in the Gut Microbiome of Pasture-Raised Chickens Fed Soy-Containing and Soy-Free Diets.pdf by Jeferson M. Lourenco (6702122)

“…Results showed that at the phylum level, regardless of diet and birds' stage of life, there was a predominance of the phylum Firmicutes, which ranged from 50 to 90% of all OTUs in all samples. …”