Mutational analysis to define the P1 and P2 fragment trypsin cleavage sites. by David A. Gross (143464)

“…<p><b>A</b>, Cells were set up as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0010796#pone-0010796-g005" target="_blank">Fig. 5</a> by expressing either K240A, K256A, R257A (all constructs are V5 tagged) and compared to wild-type FIT2-V5 (WT) in limited trypsin digestion time course assays as indicated. …”

Inflammasome elements are important for TIN progression, and inhibition of the xanthine oxidoreductase system attenuates the development of this disease. by Matheus Correa-Costa (119464)

“…WT group). In addition, allopurinol-treated animals exhibited renoprotection, as demonstrated by decreased serum creatinine levels (G) (ANOVA test - p<0.0001, with Tukey post test *p<0.01 vs. adenine group), fibrosis deposition (H) (ANOVA test - p<0.0001, with Tukey post test *p<0.001 vs. adenine group), tubular dilation (I) (ANOVA test - p = 0.0001, with Tukey post test *p<0.01 vs. adenine group), tissue uric acid levels (J) (ANOVA test p = 0.0159, with Tukey post test *p<0.05 vs. adenine group), presence of ox-LDL (K) (ANOVA test - p = 0.0211, with Tukey post test, *p<0.05 vs. adenine group) and (L) GSH/GSSG ratio (ANOVA test - p = 0.0002, with Tukey post test *p<0.001 vs. control and allopurinol groups). n = 5 animals/group.…”

Simulations suggest spatial confinement causes the late-stage rearrangement of sarcolytes. by Daiki Wakita (8080223)

“…<p>Parameter changes to slow down the muscle units were performed from 30 to 50 hAPF (steps 129,600–273,600). (a–e) Snapshots of the left halves of simulation fields at 40 and 50 hAPF: (a) spatial confinement, (b) decrease in the self-propelling force strength of hemocytes, (c) increase in the friction coefficient of all the particles, (d) increase in the adhesion strength between a hemocyte and a fat body cell, (e) increase in the adhesion strength between hemocytes. …”

Osteopontin ELISA. by M. L. Arffa (3390416)

“…Data are presented as mean ± standard deviation of the mean. Treatment with 2μg/ml of EGCG caused a significant ~2.5-fold decrease in OPN protein levels compared with no treatment control, and only inhibition of miR-221 abrogated these effects (7.96 ng/ml ± 0.03 ng/ml vs 20.17ng/ml ± 0.32ng/ml; 19.76 ng/ml ± 0.95 ng/ml; all <i>P</i><0.01). …”

Anti-ß₁EC2 antibody titersinduced by immunisation with GST-ß₁EC2 fusion proteins. by Valérie Boivin-Jahns (5645957)

“…<p>The time courses of the mean relative antibody titers after start of treatment as determined by ß₁EC2 ELISA are shown for the HF vehicle group (grey squares, n = 9) and the COR-1 treatment groups receiving 0.25mg/kg (white triangles, n = 4), 1 mg/kg (black squares, n = 20), 2 mg/kg (black cross, n = 5), and 4 mg/kg BW COR-1 (grey circle, n = 9) as bolus injections, respectively. …”

Structural Stability and Flexibility Analysis of MEV, TLR2-MEV, and TLR4-MEV Systems During Molecular Dynamics Simulation. by Masoumeh Beig (19959198)

“…The TLR2-MEV and TLR4-MEV complexes remained compact with an Rg of approximately 2.5 nm, whereas the MEV system showed a decrease in Rg, stabilizing near 1.0 nm. …”

The mechanistic model training and test performance on multiple omics datasets show qualitative and quantitative agreement. by Cemal Erdem (11054081)

“…The error bars represent the standard error of the mean from three independent biological replicates. …”

EVALUATION OF CERVICAL ALIGNMENT AND ITS RELATIONSHIP WITH THORACIC KYPHOSIS AND SPINOPELVIC PARAMETERS AFTER SCOLIOSIS CORRECTION SURGERY by Murilo Tavares Daher (4703848)

“…Regarding Lenke’s classification, 14 were of group 1, five of group 2, 10 of group 3, eight of group 4, four of group 5 and two of group 6. …”

Longitudinal evaluation of visual function and structure for detection of subclinical Ethambutol-induced optic neuropathy by Ki Won Jin (6598094)

“…Subclinical toxicity was found in 22 eyes of 14 patients (i.e., 13% of 168 eyes), in the forms of VFI decrease (VF index, 9 eyes of 6 patients), quadrant RNFL thickness increase (5 eyes of 4 patients), and VF pattern defect (12 eyes of 6 patients). 73% of the patients showed recovery to the baseline at 1 month post-stoppage. …”

Table1_Constructing more comprehensive pollination networks: integrating diurnal and nocturnal pollen data with visitation in a subalpine wetland community.xlsx by Yue Teng (621662)

“…Given that the diurnal pollen data showed new links that were preferentially attached to highly connected nodes, the level of asymmetric specialization did not decrease; however, nestedness increased 1.3-fold, and mean pollinator connectivity from 3.1 to 5.1. …”

DataSheet1_Dose-dependent reduction of lymphocyte count and heart rate after multiple administration of LC51-0255, a novel sphingosine-1-phosphate receptor 1 modulator, in healthy... by Inyoung Hwang (8399295)

“…LC51-0255 was accumulated with a mean accumulation ratio of 5.17–6.64. During the study, LC51-0255 was generally well tolerated. …”

Data_Sheet_1_A preliminary study of diffusion tensor imaging in root entry zone of primary trigeminal neuralgia.docx by Yiwen Wang (666361)

“…</p>Results<p>A total of 17 patients with PTN (mean age 59.29 ± 8.53; 5 men) and 34 HCs (mean age 57.70 ± 6.37; 10 men) were included. …”

Temporal changes in the clinical-epidemiological profile of patients with Chagas disease at a referral center in Brazil by Alejandro Marcel Hasslocher-Moreno (3460265)

“…Regarding the patients who were followed up at the referral center, there was a progressive increase in the mean age and a concomitant decrease in the number of new patients. …”

Image2_Contamination of per- and polyfluoroalkyl substances in the water source from a typical agricultural area in North China.JPEG by Xiaowei Wang (27921)

“…With the increase in the carbon chain length, the mean concentrations of PFASs in groundwater generally showed a decreasing trend. …”

A: <i>In vitro</i> immunomodulatory effect of HD-MSCs and ALL-MSCs on HD-PBMCs. by Antonella Conforti (481227)

“…Each bar represents the mean ± SD of multiple experiments (each point being in triplicate) with MSCs obtained from 10 ALL patients (at each time-point) and 10 HDs. …”

Image4_Constructing more comprehensive pollination networks: integrating diurnal and nocturnal pollen data with visitation in a subalpine wetland community.jpeg by Yue Teng (621662)

“…Given that the diurnal pollen data showed new links that were preferentially attached to highly connected nodes, the level of asymmetric specialization did not decrease; however, nestedness increased 1.3-fold, and mean pollinator connectivity from 3.1 to 5.1. …”

Circulatory Responses to Asphyxia Differ if the Asphyxia Occurs <i>In Utero</i> or <i>Ex Utero</i> in Near-Term Lambs by Kristina S. Sobotka (659908)

“…Mean arterial pressure initially increased then decreased in both groups.…”

Image1_Constructing more comprehensive pollination networks: integrating diurnal and nocturnal pollen data with visitation in a subalpine wetland community.jpeg by Yue Teng (621662)

“…Given that the diurnal pollen data showed new links that were preferentially attached to highly connected nodes, the level of asymmetric specialization did not decrease; however, nestedness increased 1.3-fold, and mean pollinator connectivity from 3.1 to 5.1. …”

Table2_Constructing more comprehensive pollination networks: integrating diurnal and nocturnal pollen data with visitation in a subalpine wetland community.docx by Yue Teng (621662)

“…Given that the diurnal pollen data showed new links that were preferentially attached to highly connected nodes, the level of asymmetric specialization did not decrease; however, nestedness increased 1.3-fold, and mean pollinator connectivity from 3.1 to 5.1. …”

Networks with passive cross-links and no filament turnover undergo three stages of deformation in response to an extensional stress. by William M. McFadden (4692130)

“…<b>C)</b> Plots of the mean stress and cumulative network strain vs time for the simulation in (B), illustrating the three stages of deformation: (i) A fast initial deformation accompanies rapid buildup of internal network stress; (ii) after a characteristic time <i>τ</i>_<i>c</i> (indicated by vertical dotted line) the network deforms at a constant rate, i.e. with a constant effective viscosity, <i>η</i>_<i>c</i>, given by the slope of the dashed line; (iii) at long times, decrease in filament density, and loss of network connectivity, leads to material failure (see inset).…”