Metformin reduces lipid stores and causes intestinal fluid imbalance. by Cathy Slack (251729)

“…(<b>B</b>) Metformin treatment of female flies does not affect the number of fecal deposits produced per fly over a 24 hour period (<i>P>0.05</i>, Wilcoxen test, n = 5 (5 flies per replicate)). (<b>C</b>) Metformin treatment of female flies does not affect the size of fecal deposits as measured by the mean area of deposits (<i>P>0.05</i>, Wilcoxen test, n = 5 (5 flies per replicate)). …”

Tumour before resistance and at acquired resistance. by Oluf Dimitri Røe (109870)

“…Two novel putative resistance markers, KRT7/CK7 and TYMP both gene and protein was significantly increased at resistance. SPARCL1 showed a significant decrease in gene expression, but its encoded protein, hevin, showed only a slight decrease in protein staining intensity.…”

miR-205 knockout mice demonstrate postnatal lethality. by D’Juan T. Farmer (467577)

“…Clear skin defects are observed with a gross decrease in the overall size of the KO. …”

The PI3K/Akt- and NO-related pathways contribute to EPC tube formation affected by oxLDL. by Feng-Yen Lin (143413)

“…In contrast, 10–50 μg/mL oxLDL had decreasing production of NO observed (n = 5). …”

Other glycines substitutions that destabilize BH4-Bcl-2’s by Giovanni Monaco (452223)

“…Both mutant peptides showed a relative decrease in α-helical conformation as assessed by spectra analysis with the CONTIN/LL deconvolution method (see provided change in α-helical percentage for each condition. …”

Data_Sheet_1_Integration of Transcriptomics and Metabolomics Reveals the Responses of Sugar Beet to Continuous Cropping Obstacle.zip by Weijuan Huang (3832738)

“…Sucrose was highly reduced in T3 (4.05-fold decrease) and T5 (2.01-fold decrease) compared to T1. …”

DataSheet1_The Efficacy and Safety of Pulmonary Vasodilators in Pediatric Pulmonary Hypertension (PH): A Systematic Review and Meta-analysis.docx by Tingting Shu (353149)

“…In total, compared with the control group treatment, pulmonary vasodilators significantly decreased the mortality (p = 0.002), mean pulmonary artery pressure (mPAP, p = 0.02), and mechanical ventilation duration (p = 0.03), also improved the oxygenation index (OI, p = 0.01). …”

DataSheet1_Profiling of the serum MiRNAome in pediatric egyptian patients with wilms tumor.PDF by Fatma S. Mohamed (19850220)

“…The ROC curve analysis revealed that multiple dysregulated miRNAs in WT, specifically hsa-miR-7-5p, hsa-miR-146a-5p, hsa-miR-378a-3p, and hsa-miR-483-5p, exhibited high diagnostic potential for WT, with AUC values exceeding 0.86. …”

Fitness reaction norms and experimental evolution design. by Thiago S. Guzella (5920229)

“…Here we genotype individual hermaphrodites at several time points during experimental evolution, at single nucleotide polymorphisms (SNPs) across pairs of chromosomes (vertical dashed lines, <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1007731#pgen.1007731.g002" target="_blank">Fig 2</a> and <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1007731#pgen.1007731.g003" target="_blank">Fig 3</a>). …”

Video_1_Acupressure versus parecoxib sodium in acute renal colic: A prospective cohort study.MP4 by Chiwei Chen (13844319)

“…The acupressure group obtained lower VAS scores at the 1st, 5th, 10th, and 20th minute than the parecoxib sodium group after initiating the intervention (mean: 4.33 vs. 7.61, mean difference (MD): 3.29, 95% CI: 0.23, 2.84; mean: 2.65 vs. 7.61, MD: 4.96, 95% CI: 4.44, 5.49; mean: 1.63 vs. 6.59, MD: 4.96, 95% CI: 4.48, 5.44; mean: 1.26 vs. 3.64 MD: 2.38, 95% CI: 1.87, 2.88; P < 0.05). …”

Non-competitive inhibition of odorant activation of an insect OR by an Orco antagonist. by Sisi Chen (166395)

“…IC₅₀ values for OX1a inhibition of responses to 10nM 3MI (47 ± 5 µM), 100nM 3MI (42 ± 7 µM) and 1uM 3MI (50 ± 4 µM) did not differ (p=0.2970, F-test). …”

Effects of TTP2515 on metabolic and calorimetry parameters in leptin-deficient mice. by Roxanne Dutia (418714)

“…(<b>C</b>) Body weight was significantly lower in TTP2515-treated mice on the 50 mg/kg dose. (<b>D</b>) Immediately upon starting the 50 mg/kg dose, mean respiratory quotient was significantly decreased in TTP2515 treated mice during the light cycle. …”

Image1_The clinical and genetic aspects of six individuals with GH1 variants and isolated growth hormone deficiency type II.tif by Xiaozhen Huang (5858690)

“…All children demonstrated GH deficiency in growth hormone stimulation tests (mean peak GH value: 2.83 ± 2.46 ng/mL). Exome sequencing for the six patients and targeted gene sequencing for their family members revealed heterozygous variants in the GH1 gene, including Exon2-5del, c.334T>C, c.291 + 1G>A, c.291 + 2T>A, 1.5 kb deletion, and 1.7 kb deletion, with four variants being novel. …”

Table1_The clinical and genetic aspects of six individuals with GH1 variants and isolated growth hormone deficiency type II.docx by Xiaozhen Huang (5858690)

“…All children demonstrated GH deficiency in growth hormone stimulation tests (mean peak GH value: 2.83 ± 2.46 ng/mL). Exome sequencing for the six patients and targeted gene sequencing for their family members revealed heterozygous variants in the GH1 gene, including Exon2-5del, c.334T>C, c.291 + 1G>A, c.291 + 2T>A, 1.5 kb deletion, and 1.7 kb deletion, with four variants being novel. …”

The Effect of Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) on Erectile Function: A Systematic Review and Meta-Analysis by Xiang Chen (10398)

“…A significant decrease in the IIFE-5 score was observed in the CP/CPPS group (pooled mean difference: −4.54, 95% CI: −5.11–−3.98; <i>P</i> < 0.01).…”

Modulation of human monocytes by exposure to mitochondrial DAMPs. by Irene Fernández-Ruiz (5653951)

“…Mean Fold decrease of MFI compared to corresponding control with no pre-treatment is shown. …”

Multiple modes of modulation of PC simple spikes during light activation of ChR2 specifically expressed in GCs. Light activation of GCs results in inhibition and/or activation of P... by Wolfgang Kruse (619565)

“…Laser power was set to 10 mW, resulting in 2.5 mW in front of light fiber. (E) Mean increase of simple spike rate from 13 PCs showing excitation during light application and mean decrease of activity of 12 PCs showing inhibition during light application. …”

Cost-Effectiveness Analysis of Testing in Different Settings, Probabilistic Sensitivity Analysis, Initiate HAART at CD4 cell count = 500 cells/µL. by Vimalanand S. Prabhu (220301)

Examples of sympathetic activity and ECG recording. by Adam Ali Ghotbi (797650)

Gene expression of CCL22 but not CXCR4 is attenuated in tumors from runners but not non-runners. by Jorming Goh (490491)