αMT Induces Severe DA Depletion in the Striatum of DAT-KO Mice by Tatyana D Sotnikova (71503)

“…</p> <p>(C) Tissue levels of NE in the frontal cortex of saline-treated WT and DAT-KO mice (<i>n</i> = 7 per group).</p> <p>(D) Dynamics of the effect of αMT (250 mg/kg IP) on tissue levels of NE in the frontal cortex of WT and DAT-KO mice (<i>n</i> = 5–8 per group). …”

Downstream molecular effects of knockdown of the expression of 5-HT_1B and 5-HT_1D receptors, on invasion and proliferation biomarkers in PaCa cells. by Nilgun Gurbuz (623605)

“…(Upper panel) Cells were transfected with 50 nM of indicated siRNAs, and after 72 h, the total RNA was extracted and the transcript levels of 5-HT_1B and 5-HT_1D were determined by standard RT-PCR as described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0105245#s2" target="_blank">Materials and Methods</a>. …”

VCC induces activation of neutrophils through TLR1/4/MyD88. by Shraddha Gandhi (21001590)

“…<p>(A) VCC induces pro-inflammatory responses during <i>V. cholerae</i> infection of neutrophils. Neutrophils isolated from bone marrow were infected with either wild type (WT) or VCC-deleted (Δ<i>hlyA</i>) variants of <i>V. cholerae</i> at the multiplicity of infection (MOI) of 10 for 4 hours. …”

Chloroquine (CQ) treatment blocks autophagosome–lysosome fusion and induces myopathy in the larva. by Jonathan Zirin (483506)

Evaluation of prevalence, biochemical profile, and drugs associated with chronic kidney disease-mineral and bone disorder in 11 dialysis centers by Rodrigo Reis Abrita (5187437)

“…Conclusion: The prevalence of patients outside the target for iPTH was 50.5%. There was a high prevalence of hyperphosphatemia (35.8%), and the minority of patients were using active vitamin D, vitamin D analogs, selective vitamin D receptor activators, and cinacalcet. …”

Evaluation of prevalence, biochemical profile, and drugs associated with chronic kidney disease-mineral and bone disorder in 11 dialysis centers by Rodrigo Reis Abrita (5187437)

“…Conclusion: The prevalence of patients outside the target for iPTH was 50.5%. There was a high prevalence of hyperphosphatemia (35.8%), and the minority of patients were using active vitamin D, vitamin D analogs, selective vitamin D receptor activators, and cinacalcet. …”

<i>P</i>. <i>aeruginosa</i> secreted virulence factors induce ER stress in primary bronchial epithelial cells. by Emily F. A. van ‘t Wout (756193)

“…Time-dependent induction of ER stress in primary bronchial epithelial cells, as assessed by <i>XBP1</i> splicing, <i>CHOP</i> and <i>GADD34</i> mRNA after treatment with CM-PAO1 (n = 5; mean ± SEM). B. Dose-response of spliced <i>XBP1</i>, <i>CHOP</i> and <i>GADD34</i> mRNA in primary bronchial epithelial cells treated with CM-PAO1 for 12 hours (n = 5; mean ± SEM). …”

Phenotypes of the shACADS and shNTC knockdown Huh7 cells. by Kerstin Matejka (6729155)

“…Western blotting analysed 10 μg of cell lysate per sample depicted exemplary for one (C) of four experiments (B). ** = p < 0.01 (one sample t-test). mRNA (A) and Protein (B) were harvested after 3 or 5 days of treatment with 0, 5, and 10 ng/mL doxycycline, respectively. *** = p < 0.001 (one-sample t-test). …”

Image_3_COVID-19 Pandemic and Trends in Clinical Trials: A Multi-Region and Global Perspective.TIF by Satoshi Nishiwaki (560641)

“…Similarly, the mean percentage change of reported results for each month in 2019 and 2020 was −5.1%, with the maximum of −27.4% observed in July 2020. …”

Image_7_COVID-19 Pandemic and Trends in Clinical Trials: A Multi-Region and Global Perspective.TIF by Satoshi Nishiwaki (560641)

“…Similarly, the mean percentage change of reported results for each month in 2019 and 2020 was −5.1%, with the maximum of −27.4% observed in July 2020. …”

<i>In vitro</i> differentiation of <i>Mecp2</i> wild type ES cells is accompanied by large scale heterochromatin reorganization. by Bianca Bertulat (126768)

“…We noticed a highly significant (p<0.0001) decrease of mean chromocenter number per nucleus within the first two weeks of differentiation. …”

Image_1_Post-eastern Mediterranean Transient Oxygen Decline in the Deep Waters of the Southeast Mediterranean Sea Supports Weakening of Ventilation Rates.jpeg by Guy Sisma-Ventura (6504992)

“…Multiannual variability in oxygen levels superimposed this trend, and is likely associated with variations in thermohaline fluxes. The 2020 mean oxygen concentration of 179.5 ± 2.3 μmol kg⁻¹ is comparable to the pre-Eastern Mediterranean Transient (EMT) mean value. …”

Effect of breathing hypoxic gas on vascular oxygenation of 4T1 and 4T07 tumors. by Narasimhan Rajaram (474255)

“…</b> 24 hours after breathing hypoxic gas, there was a significant decrease in SO₂ of the 4T1 tumors (n = 4; p = 0.04), which had returned to a mean value close to pre-hypoxia baseline. 1 animal had to be censored before the 24 hours post-hypoxia measurement. …”

Image_2_COVID-19 Pandemic and Trends in Clinical Trials: A Multi-Region and Global Perspective.TIF by Satoshi Nishiwaki (560641)

“…Similarly, the mean percentage change of reported results for each month in 2019 and 2020 was −5.1%, with the maximum of −27.4% observed in July 2020. …”

Image_6_COVID-19 Pandemic and Trends in Clinical Trials: A Multi-Region and Global Perspective.TIF by Satoshi Nishiwaki (560641)

“…Similarly, the mean percentage change of reported results for each month in 2019 and 2020 was −5.1%, with the maximum of −27.4% observed in July 2020. …”

Image_1_COVID-19 Pandemic and Trends in Clinical Trials: A Multi-Region and Global Perspective.TIF by Satoshi Nishiwaki (560641)

“…Similarly, the mean percentage change of reported results for each month in 2019 and 2020 was −5.1%, with the maximum of −27.4% observed in July 2020. …”

Summary of responses to free-flight antennal stimulation of extrinsic antennal muscles in six animals. by Armin J. Hinterwirth (109677)

“…Similarly, the Δ_speed column indicates changes in the mean body speed before and after stimulus onset. (+ +: >1 m/s²; −: <−0.5 m/s²; − −: <−1 m/s²; − − −: <−1.5 m/s²(max. was −2.8 m/s²). …”

Data_Sheet_1_COVID-19 Pandemic and Trends in Clinical Trials: A Multi-Region and Global Perspective.docx by Satoshi Nishiwaki (560641)

“…Similarly, the mean percentage change of reported results for each month in 2019 and 2020 was −5.1%, with the maximum of −27.4% observed in July 2020. …”

SF-E inhibits NMDA-induced ROS production without altering cell viability of primary cortical neurons. by Jinghua Jiang (527159)

“…<p>(A) Exposure of SF-E (0–7.5 µg/mL) to primary cortical neurons for 24 h did not alter neuronal viability as assayed by MTT. …”

Image_4_COVID-19 Pandemic and Trends in Clinical Trials: A Multi-Region and Global Perspective.TIF by Satoshi Nishiwaki (560641)

“…Similarly, the mean percentage change of reported results for each month in 2019 and 2020 was −5.1%, with the maximum of −27.4% observed in July 2020. …”