Data Sheet 1_The novel pleuromutilin derivative 22–((4-((4-nitrophenyl)acetamido)phenyl)thio)deoxy pleuromutilin possesses robust anti-mycoplasma activity both in vitro and in vivo... by Xirui Xia (12075476)

“…</p>Results<p>The results show that compound 16C has low toxicity (LD₅₀ > 5,000 mg/kg). Its pharmacokinetic profile is characterized by a short time to maximum concentration (Tmax = 0.24 h), high bioavailability (F = 71.29%), and short elimination half-life (T_1/2kel) (intramuscular and intravenous administration was 2.20 and 1.89 h, respectively). …”

Data Sheet 5_The novel pleuromutilin derivative 22–((4-((4-nitrophenyl)acetamido)phenyl)thio)deoxy pleuromutilin possesses robust anti-mycoplasma activity both in vitro and in vivo... by Xirui Xia (12075476)

“…</p>Results<p>The results show that compound 16C has low toxicity (LD₅₀ > 5,000 mg/kg). Its pharmacokinetic profile is characterized by a short time to maximum concentration (Tmax = 0.24 h), high bioavailability (F = 71.29%), and short elimination half-life (T_1/2kel) (intramuscular and intravenous administration was 2.20 and 1.89 h, respectively). …”

Image1_Identification of Ferroptosis-Associated Genes in Prostate Cancer by Bioinformatics Analysis.TIF by Qijun Wo (12992781)

“…<p>Background: In order to reveal the functions of ferroptosis in prostate cancer (PCa), a ferroptosis potential index (FPI) was built. …”

Composition of basal diet. by Mahmoud Ghazaghi (18397236)

“…Five supplemental levels (0.05, 0.10, 0.15, 0.20, and 0.25% of diet) of DL-Met or nano-Met were added to a basal diet containing 0.35% standardized ileal digestible (SID) methionine to create 11 experimental diets, including a basal diet and 10 experimental diets containing 0.40, 0.45, 0.50, 0.55, and 0.60% SID-Met, respectively. …”

Data Sheet 3_The novel pleuromutilin derivative 22–((4-((4-nitrophenyl)acetamido)phenyl)thio)deoxy pleuromutilin possesses robust anti-mycoplasma activity both in vitro and in vivo... by Xirui Xia (12075476)

“…</p>Results<p>The results show that compound 16C has low toxicity (LD₅₀ > 5,000 mg/kg). Its pharmacokinetic profile is characterized by a short time to maximum concentration (Tmax = 0.24 h), high bioavailability (F = 71.29%), and short elimination half-life (T_1/2kel) (intramuscular and intravenous administration was 2.20 and 1.89 h, respectively). …”

Data Sheet 1_The effect of vagus nerve stimulation on heart rate and respiration rate and their impact on seizure susceptibility in anaesthetized rats under pentylenetetrazol.pdf by Javier Chávez Cerda (20913026)

“…Additionally, the latency of the seizures was longer in the sham VNS (291.5 ± 84.4 s) compared to standard VNS (200.5 ± 59.5 s) and breathing-synchronized VNS (206.9 ± 66.0 s), meaning that the seizures under stimulation were starting earlier. …”

DataSheet_1_Dynamics of IgG antibody response against Plasmodium antigens among Nigerian infants and young children.pdf by Colleen M. Leonard (12199196)

“…Seropositivity showed a similar decline with the lowest seropositivity against AMA1 and PfMSP1 at 10-12 months, though remaining above 50% during the first 2 years of life in higher transmission areas. …”

Temporal distribution of <i>P</i>. <i>vivax</i> malaria episodes and immune response targeting region II of the Duffy binding protein (DBPII), Rio Pardo Settlement, Amazonas, Brazi... by Flora S. Kano (548431)

“…(<b>C</b>) DBPII binding inhibitory antibodies (BIAbs) had a slightly decreased frequency at the 12 months follow-up examination. …”

Negative regulation of protein-coding genes suggests increased genomic auto-immunity of <i>D</i>. <i>simulans</i> alleles. by Luyang Wang (476973)

“…<p>(A) The number of genes whose expression levels are decreased/increased (>1.5 fold, blue/red) in the presence of each transgene as compared to the corresponding mutant. …”

Table1_Effectiveness of early heparin therapy on outcomes in critically ill patients with sepsis-induced coagulopathy.docx by Jia-Jia Huang (243641)

“…Further analysis showed that treatment with 6,250–13750 IU/day of unfractionated heparin associated with a decreased risk of intensive care unit mortality. …”

Table 1_Multi-omics reveals total flavones from Abelmoschus manihot (L.) Medik. [Malvaceae] ameliorate MAFLD via PI3K/AKT/mTOR-mediated autophagy.docx by Chao Lv (335727)

“…Ultra-high-performance liquid chromatography-quadrupole orbitrap mass spectrometry (UHPLC-QTOF-MS) was used to identify the metabolites in TFA. MAFLD mice induced by a high-fat diet were treated with TFA at doses of 50 and 100 mg/kg. …”

Table 2_Multi-omics reveals total flavones from Abelmoschus manihot (L.) Medik. [Malvaceae] ameliorate MAFLD via PI3K/AKT/mTOR-mediated autophagy.docx by Chao Lv (335727)

“…Ultra-high-performance liquid chromatography-quadrupole orbitrap mass spectrometry (UHPLC-QTOF-MS) was used to identify the metabolites in TFA. MAFLD mice induced by a high-fat diet were treated with TFA at doses of 50 and 100 mg/kg. …”

<i>d-myc</i> knockdown can rescue the Malpighian tubule defects of <i>BicC</i> mutants. by Chiara Gamberi (499883)

“…(F) Representative d-Myc and tubulin immunoblots of extracts from five Malpighian tubules dissected from flies of the following genotypes: <i>wild-type</i> (<i>wt</i>); heterozygotes for the Gal4 driver <i>c724</i> and <i>c42</i> constructs (<i>Gal4/+</i>); heterozygotes for the d-<i>myc</i>^<i>RNAi</i> construct (<i>myc</i>^<i>RNAi</i>/+); <i>myc</i> RNAi driven by <i>c724</i> and <i>c42</i> (<i>Gal4>myc</i>^<i>RNAi</i>); <i>BicC</i>^{<i>YC33/YC33</i>} homozygotes (<i>BicC</i>^<i>YC33</i>); <i>myc</i> RNAi driven in <i>BicC</i>^<i>YC33</i> homozygotes (<i>BicC</i>^<i>YC33</i>; <i>Gal4>myc</i>^<i>RNAi</i>). …”

DataSheet_1_Temperature and elevated CO2 alter soybean seed yield and quality, exhibiting transgenerational effects on seedling emergence and vigor.docx by Naflath Thenveettil (19262185)

“…When the growing temperature increased from optimum to high, the seed oleic acids increased (63%), while linoleic and linolenic acids decreased (- 28% and - 43%, respectively). Significant temperature and CO₂ effects were observed in progenies with the highest maximum seedling emergence (80%), lesser time to 50% emergence (5.5 days), and higher seedling vigor from parents grown at low-temperature treatment under eCO₂.…”

<i>Fgf20</i> is necessary for formation of the lateral compartment of the organ of Corti. by Sung-Ho Huh (191072)

“…Total numbers of hair cells were decreased by 50% in <i>Fgf20^βGal/βGal</i> cochlea. …”

Anorectal dysfunction after radical cystectomy for bladder cancer by Fredrik Liedberg (39980)

PIEZO1 activity is predicted to regulate wound closure by hindering coordinated directionality. by Jinghao Chen (5145005)

“…Scale bar = 10 <i>μ</i>m, Time bar = 5 min. <b>(B)</b> Cumming plots showing simulation results using the calibrated model (^CM) to predict how PIEZO1 affects normalized wound closure (<i>left plots</i>) and wound edge length (<i>right plots</i>) in simulated Control_GoF monolayers (<i>dark gray</i>), <i>Piezo1</i>-GoF monolayers without altered coordinated directionality parameters (<i>white</i>), and <i>Piezo1</i>-GoF monolayers with coordinated directionality decreased (<i>green</i>). …”

Deletion of Msh2 in medium-spiny neurons delays nuclear huntingtin phenotypes. A, B. by Marina Kovalenko (136557)

“…<p>Nuclear mutant huntingtin immunostaining is decreased in the striata of five-month old <i>HdhQ111</i>/+ mice with deletion of <i>Msh2</i> in MSNs. …”

<i>In vitro</i> data showing that IGF+HGF stimulation enhances Sca-1⁺/CD31⁻ cell survival and proliferation and protects co-cultured stressed HL-1 from apopto... by Xiaohong Wang (93777)

“…Data are presented as mean+/−SEM.</p>…”

Image_1_BML-111 Reduces Neuroinflammation and Cognitive Impairment in Mice With Sepsis via the SIRT1/NF-κB Signaling Pathway.TIF by Shangwen Pan (5648291)

“…Boc-2 (50 μg/kg) was administered intracerebroventricularly 30 min before CLP, and EX527 (10 μg) was administered every 2 days for a total of three times before CLP, also intracerebroventricularly. …”