Discovery of N‑Substituted Acetamide Derivatives as Promising P2Y₁₄R Antagonists Using Molecular Hybridization Based on Crystallographic Overlay by Wenjin Liu (4016060)

“…Thus, compound <b>I-17</b>, with potent P2Y₁₄R antagonistic activity, <i>in vitro</i> and <i>in vivo</i> efficacy, and favorable bioavailability (<i>F</i> = 75%), could be a promising lead compound for acute gouty arthritis.…”

Discovery of N‑Substituted Acetamide Derivatives as Promising P2Y₁₄R Antagonists Using Molecular Hybridization Based on Crystallographic Overlay by Wenjin Liu (4016060)

“…Thus, compound <b>I-17</b>, with potent P2Y₁₄R antagonistic activity, <i>in vitro</i> and <i>in vivo</i> efficacy, and favorable bioavailability (<i>F</i> = 75%), could be a promising lead compound for acute gouty arthritis.…”

Dynamics of phospholipids at different stages during microspore embryogenesis of <i>Brassica napus</i>. by Xin-Qiao Du (13150022)

Characterization of fecal steroid profiles bison, elk, moose, mule deer, and pronghorn based on the relative abundances of sterols, stanols, and stanones and bile acids in individu... by John A. F. Wendt (19976392)

Temsirolimus increases progerin clearance via autophagy. by Diana Gabriel (3608093)

Correlations among clinical illness signs. by Aiden E. Juge (12986438)

Analysis of MD simulations for the SP domain of native PC and its mutant structures (L305R, W342C, G403R, V420E, and W444C) over 200 ns simulations. by Mahvash Farajzadeh-Dehkordi (17468232)

Mild hypoxic-ischemic encephalopathy piglet model. by Dawn B. Lammert (21175128)

Study flowchart. by Cansu Cosgun (15195276)

Nicotine as a Catalyst for Chlorination Promoted by Hypochlorous Acid: Experimental and Theoretical Studies by Valdecir F. Ximenes (471290)

PowerPoint Slides for: Vitamin K Metabolism in a Rat Model of Chronic Kidney Disease by McCabe K.M. (3346673)

Shrimp allergen extract (SAE) immunotherapy preventing the development of allergies. by Honey Dzikri Marhaeny (20480031)

“…SAE desensitization successfully decreased transcription of (A) <i>FcεR1α</i> mRNA (n = 6 mice per group) and (B) IL-4 mRNA—relative to NC—in the ileal tissue (n = 3 mice per group), and suppressed the production of the pro-inflammatory cytokine (C) IL-4 in serum (n = 6 mice per group). …”

Role of ALIX and TSG101 in the entry of PEDV or PEAV VLP into Vero cells. by Xiongnan Chen (13307178)

Effect of treatment with CNCs on inflammation and fibrosis in hamsters infected with <i>O</i>. <i>viverrini</i> and fed an HFF diet. by Chutima Sitthirach (12700144)

Ecdysone response genes are expressed in the ovary of <i>R</i>. <i>prolixus</i> adult females. by Samiha Benrabaa (14817602)

NPC1 mutant fibroblasts and their fragmented mitochondria have a proper response to serum withdrawal and reintroduction. by Collin M. MacLeod (17512385)

Temporal transcript expression of ecdysone response genes in ovaries. by Samiha Benrabaa (14817602)

Disturbed polar localization of auxin efflux carrier PIN1 under suppressed expression of <i>CDS1</i> and <i>CDS2</i>. by Xin-Qiao Du (13150022)

Designing Reaction Coordinate for Ion-Induced Pore-Assisted Mechanism of Halide Ions Permeation through Lipid Bilayer by Umbrella Sampling by Anjana V. Mathath (17552017)

Image_1_Alteration of muscle activity during voluntary rehabilitation training with single-joint Hybrid Assistive Limb (HAL) in patients with shoulder elevation dysfunction from ce... by Margaux Noémie Lafitte (14079729)

“…This study aims to monitor the changes in muscle activity and motion during shoulder HAL rehabilitation in several patients suffering from shoulder elevation dysfunction from cervical radicular origin. 8 patients (6 males, 2 females, mean age 62.4 ± 9.3 years old) with weakness of the deltoid muscle resulting from a damage to the C5 nerve root underwent HAL-assisted rehabilitation. …”