TLR3 deficiency promoted the activation of TGF-β1/Smad2/3 pathway and myofibroblast caused by <i>C</i>. by Yuru Wang (846969)

Supplementary Material for: Should Colorectal Cancer Screening in Portugal Start at the Age of 45 Years? A Cost-Utility Analysis by Currais P. (10117210)

“…<b><i>Results:</i></b> In Portugal, in 1993–2010, there was an increase in CRC incidence of 17% (from 25 to 30/100,000), 35% (from 39 to 54/100,000), and 71% (from 52 to 97/100,000) in patients aged 45–49 years, 50–54 years, and 55–59 years, respectively. The mortality rate of patients aged 45–54 years remained stable between 2003 and 2016 (12/100,000) as a counterpoint to a moderate decrease in those aged 55–64 years (from 38 to 35/100,000) and a sharp reduction in those aged 65–75 years (from 93 to 75/100,000). …”

Image_1_Hsa_circ_0000479 as a Novel Diagnostic Biomarker of Systemic Lupus Erythematosus.TIF by Gangqiang Guo (3278922)

“…Western blotting revealed that the expression of Wnt-16 protein was significantly decreased in SLE.</p><p>Conclusion: Our results suggest that hsa_circ_0000479 has potential as a novel biomarker for the diagnosis of SLE.…”

Image_2_Hsa_circ_0000479 as a Novel Diagnostic Biomarker of Systemic Lupus Erythematosus.TIF by Gangqiang Guo (3278922)

“…Western blotting revealed that the expression of Wnt-16 protein was significantly decreased in SLE.</p><p>Conclusion: Our results suggest that hsa_circ_0000479 has potential as a novel biomarker for the diagnosis of SLE.…”

Supplementary Material for: The Impact of Early Positive Studies on the Evolution of Extracorporeal Albumin Dialysis Literature: A Bibliometric Analysis by Chaba A. (17146885)

Verification of sgRNA Knockout Efficiency in HeLa cells. by Lucai Wang (22050158)

Year and holiday effects. by Wael Ghada (11719000)

S1 Graphical abstract - by Lefei Yu (12274846)

“…<div><p>A number of studies demonstrate the therapeutic effectiveness of <i>Radix Bupleuri</i> (RB) and <i>Hedysarum Multijugum Maxim</i> (HMM) in treating liver fibrosis, but the exact molecular mechanisms remain unclear. …”

The top 10 hub targets. by Lefei Yu (12274846)

“…<div><p>A number of studies demonstrate the therapeutic effectiveness of <i>Radix Bupleuri</i> (RB) and <i>Hedysarum Multijugum Maxim</i> (HMM) in treating liver fibrosis, but the exact molecular mechanisms remain unclear. …”

Original images for blots and gels requirements. by Lefei Yu (12274846)

“…<div><p>A number of studies demonstrate the therapeutic effectiveness of <i>Radix Bupleuri</i> (RB) and <i>Hedysarum Multijugum Maxim</i> (HMM) in treating liver fibrosis, but the exact molecular mechanisms remain unclear. …”

The top 10 active ingredients. by Lefei Yu (12274846)

“…<div><p>A number of studies demonstrate the therapeutic effectiveness of <i>Radix Bupleuri</i> (RB) and <i>Hedysarum Multijugum Maxim</i> (HMM) in treating liver fibrosis, but the exact molecular mechanisms remain unclear. …”

PEG10-derived VLPs are naturally released by human cells. by Will Campodonico (20485651)

The flow chart. by Lefei Yu (12274846)

“…<div><p>A number of studies demonstrate the therapeutic effectiveness of <i>Radix Bupleuri</i> (RB) and <i>Hedysarum Multijugum Maxim</i> (HMM) in treating liver fibrosis, but the exact molecular mechanisms remain unclear. …”

The active ingredients in RB-HMM. by Lefei Yu (12274846)

“…<div><p>A number of studies demonstrate the therapeutic effectiveness of <i>Radix Bupleuri</i> (RB) and <i>Hedysarum Multijugum Maxim</i> (HMM) in treating liver fibrosis, but the exact molecular mechanisms remain unclear. …”

Brg1 inhibition reduces KSHV lytic reactivation. by Praneet Kaur Sandhu (21156149)

Table_1_Case Report: A Novel Mutation in NFKB1 Associated With Pyoderma Gangrenosum.DOCX by Ran Fang (533948)

“…The functional analysis showed that the variant caused reduced phosphorylation of p105 and resulted in the decreased processing of p105 to p50. We conclude that the patient's symptoms were caused by dysregulation of the NF-κB signaling pathway.…”

Table_2_Case Report: A Novel Mutation in NFKB1 Associated With Pyoderma Gangrenosum.DOCX by Ran Fang (533948)

“…The functional analysis showed that the variant caused reduced phosphorylation of p105 and resulted in the decreased processing of p105 to p50. We conclude that the patient's symptoms were caused by dysregulation of the NF-κB signaling pathway.…”

Poly (I:C) intervention presented significantly beneficial on the liver lesion, liver inflammation and biliary injury caused by <i>C</i>. by Yuru Wang (846969)

Recognition of Double Strand Breaks by a Mutator Protein (MU2) in <em>Drosophila melanogaster</em> by Raghuvar Dronamraju (204100)

“…Studies pertaining to the generation, maintenance, and biological effects of telomere formation are limited in metazoans. A mutation, <em>mu2^a</em>, in <em>Drosophila melanogaster</em> decreases the rate of repair of double strand DNA breaks in oocytes, thus leading to chromosomes that have lost a natural telomere and gained a new telomere. …”

Day of the week effect. by Wael Ghada (11719000)

“…This indicates a decrease in daily hospital admissions by 0.884*3143.5 = 2779 on Saturdays compared to Fridays.…”