TgPH1 retains membrane association in genetically-impaired PIKfyve cells. by Krishna Chintaluri (5340959)

“…<p>A. Live-cell imaging of Cos-7 cells expressing NES-iRFP-TgPH1 treated with vehicle alone or with 100 nM apilimod or 1 μM YM201636 for 1 h; the drugs cause a characteristic appearance of swollen vacuoles, some of which labelled with the TgPH1 probes. …”

2-DG reduced amyloid pathology through activation of the non-amyloidogenic pathway in 3xTgAD mice. by Jia Yao (323339)

“…Brain sections were stained for amyloid species (6E10) and microglia marker (Iba I). A, 2-DG induced significant decrease in APP, 56 kD, 27 kD and 16 kD Aβ oligomer protein level. …”

Effect of Gli blockade on growth of human ovarian cancer cells <i>in vivo</i>. by Qi Chen (144168)

“…Treatment was initiated in all groups (n = 8 each group) when mean tumor volume had reached 100 mm³. …”

Ecosystem organic carbon storage and their drivers across the drylands of China by Longwei Dong (10525061)

“…The effects of environmental variables on carbon density were found to be contingent on ecosystem type and soil depth. Mean annual precipitation had a strong positive effect on the spatial distributions of vegetation carbon density in both types of ecosystems. …”

Functional characterization of Ca²⁺-induced Cl⁻ responses of TG neurons. by Nicole Schöbel (120873)

“…C: Quantification of neurons displaying either a decrease, an increase, or no alteration of [Cl⁻]_i upon ATP stimulation (n = 76). …”

The potential mechanism for the elevated ROS levels. by Weimin Wang (145168)

“…(D) Gene expression of NOX2 and NOX4 in the control and Ara-C groups. (E) The mean increase/decrease of mitochondrial ROS and total ROS in Ara-C cells treated with DPI or Mito-Tempo. …”

Co-cultures of RGCs and Müller cells. by Xandra Pereiro (3924971)

“…The data represent the mean ± SEM. Scale bar = 100 μm, *p<0.05.</p>…”

TF maps and averaged profile of alpha oscillatory response. by Audrey Breton (534422)

“…<p>A) TF map depicting the color-coded mean energy (in μV²) in response to faces in the three player rank conditions (Highest, Middle and Lowest) at the electrode Pz. …”

SIM promotes axon like neuritogenesis in SH-SY5Y cells. by Varshiesh Raina (457377)

“…Note that SIM led to a significant (<i>p</i> < 0.05^*) increase in protein expression of NFL and β3-tubulin whereas GAP43 and Nestin displayed no change. phospho-Tyrosine Hydroxylase serine 31 (pTH-Ser31), a dopaminergic neuronal functional marker showed a significant (<i>p</i> < 0.05^*) decrease in protein levels at 6 hrs post SIM treatment. …”

Health and Economic Burden of Obesity in Brazil by Ketevan Rtveladze (142281)

“…However, an effective intervention to decrease obesity by just 1% will substantially reduce obesity burden and will have a significant effect on health care expenditure.…”

Estrogen dose-dependent depletion of oocytes. by Clémentine Chalmey (5657233)

“…Higher magnification of TRA98 labeling shows oocyte-specific expression (C). Scale bar = 100 µm. D–E. Stereological estimation of ovarian volume (D) and oocyte numbers per ovary (E) at PND3 in controls, and as a function of E2 dose, show a dose-dependent decrease of both parameters. …”

Effect of the lytic enzyme PeiR on M1 growth <i>in vitro</i>. by Sinead C. Leahy (244590)

“…Chloroform, a known potent inhibitor of methanogens, resulted in a similarly reduced methane yield (B), but the decrease in culture density was less (A), as expected since it halts metabolism rather than lysing cells. …”

RAGE blocking and APP inhibition synergistically reduce oxidative stress, apoptosis and rescue sequential gliocentric cell fate change in DS HNPs. by Jie Lu (139953)

“…(B) Graphs show the S100B stimulation for 24 hours dose dependently increase H₂O₂ production and decrease mitochondrial membrane potential which can be blocked by RAGE antibody (1 µg/ml) or dalteparin sodium (1 IU/ml) (<b><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0022126#pone.0022126.s005" target="_blank">Figure S5A</a></b>). …”

Effect of sagopilone (SAG) on cell proliferation, tubulin cytoskeleton, cell cycle and apoptosis of lung cancer cells. by Sebastian Winsel (222664)

“…A549 cells were incubated for 72 hrs with vehicle, or 2.5 nM, 5 nM, 10 nM, 40 nM, or 100 nM SAG. …”

Steady state flux and G6P and F6P concentrations. by Maria José Ramírez-Bajo (515922)

“…<p>Decrease of flux of steady-state TrP production from Glc (A,D) and maintenance of G6P (B,E) and F6P (C,F) steady-state concentrations, in the presence of different pre-incubating concentrations of metals. …”

Effect of cycloheximide on development of <i>tko</i>^<i>25t</i> and wild-type flies. by Esko Kemppainen (64909)

“…Based on pairwise <i>t</i> tests, and considering all the flies of a given sex and genotype cultured at a specific drug concentration as a single population, mean eclosion times were significantly different (<i>p</i> < 0.05) at different cycloheximide concentrations, apart from <i>tko</i>^<i>25t</i> flies of either sex at 100 μg/ml, which were not different from <i>tko</i>^<i>25t</i> flies cultured in the complete absence of the drug. …”

The contributions of the saturable and non-saturable components to total flux of [³H]-ADMA into the capillary depletion samples are plotted against the unlabelled ADMA c... by Mehmet Fidanboylu (343341)

“…<p>The measured values are the mean ±SEM for 4-5 mice (homogenate), 4-5 mice (supernatant) and 5 mice (pellet except at 100 μM where it was 1 mouse) at each of the 6 ADMA concentrations and has been [¹⁴C]-sucrose corrected. …”

Global assessment of methylation levels and confounders contributing to hypomethylation in common CNV regions. by Corey T. Watson (250356)

“…Each plot shows a 100 bp moving average. Although a small decrease in methylation level is evident within CNVs compared to flanking regions, overall mean methylation levels within CNV regions (69%) are very similar to the genome average (70%). …”

The adhesion genes are activated by TAp63β but not by ΔNp63β in Caski cells. by Youcef Ben Khalifa (203743)

“…<p>(A) Real-time PCR performed in Caski cells infected with recombinant adenoviruses expressing GFP compared to TAp63β (upper panel) or ΔNp63β (lower panel) at increasing m.o.i. (20, 50 and 100). …”

DYNLT1 knockdown aggravates hypoxia-induced damage of mitochondria: mPT induction, MMP disruption and reduction of cellular viability. by Ya-dong Fang (338292)

“…<b>C</b>, −DYNLT1 cells showed a dramatic decrease in cell viability compared with WT and +DYNLT1 cells; WT and +DYNLT1 cells were not significantly different. …”