Modulation of cell viability by 8-Br-cGMP/vardenafil. by Sara D’ Alessandro (14886399)

“…<p>COS7, K1 and Nthy-ori 3–1 cell lines were treated 24 h with increasing 8-Br-cGMP and vardenafil (100 nM– 500 μM range). Cell viability was evaluated by MTT assay and indicated as an absorbance detected at the 570 nm wavelength. 4 μM thapsigargin served as a positive control (Tha) for cell viability decrease and results were compared by Kruskal Wallis test and Dunn’s post-test (*significantly different <i>versus</i> untreated sample; p < 0.05; means ± SEM; n = 6 to 8). …”

CStS recapitulate MSNs degeneration observed in R6/2 mouse model. by Catia C. Proenca (431486)

“…Neurodegeneration is observed as a decrease in marker intensity. F) Left: quantification for the ratio of striatal NeuN and DAPI positive nuclei in WT and R6/2 slices at DIV21. …”

Ionizing radiation–induced DSBs and repair. by Jim Westmoreland (260234)

“…<p>Haploid cells growing logarithmically in YPDA media were arrested at G2/M with nocodazole and γ-irradiated with 5 to 80 krads from a Cs source. Cells from the 80 krad dose were returned to YPDA containing nocadazole and incubated for up to 4 hours to allow repair of DSBs (A) DSBs and repair in WT and <i>exo1Δ</i> strains. …”

ROP18 directly phosphorylates Irga6 at T102 and T108 in vitro. by Tobias Steinfeldt (154465)

“…The autoradiogram reveals efficient phosphorylation of wt Irga6 and a decrease in signal intensity for all Irga6 alanine mutants. …”

A Reappraisal of the Mechanism by Which Plant Sterols Promote Neutral Sterol Loss in Mice by Gemma Brufau (215229)

“…PS feeding resulted in a dose-dependent decrease of fractional cholesterol absorption (∼2–7-fold reduction) in wild-type mice and ∼80% reduction in Abcg5^-/- mice. …”

Role of sT-interacting proteins in MCV transcription and viral replication. by Kyle Rapchak (13833941)

“…A-485 treatment significantly decreases early and late gene expression at 1.0, 5.0, and 10.0 μM in MCVΔsT transfected with sT. …”

Developmental changes in DKO mice. by Lindsay Wieczorek (171734)

“…<p>Two genes identified with microarray analysis and showing the most significant change between WT and DKO mice, (<b>A</b>) Slc11a2 (n = 5, *p≤0.0001), with a −1.3 fold change, and (<b>B</b>) Lynx1 (n = 5, *p≤0.0001), with −1.4 fold change, were confirmed via RT-PCR. …”

Influence of MgCl and ATP on primer unblocking by AZT-resistant RT by Valérie Goldschmidt (13343)

“…All rights reserved</p> () ssDNA synthesis was performed in the presence of 3.5 mM ATP and 4 µM AZTTP with wt or AZT-resistant RT at 2 or 6 mM MgCl. …”

Impact of astrocyte depletion upon non-basement membrane extracellular matrix (ECM) components. by Lisa Allnoch (10583549)

“…Immunohistochemistry detecting decorin showed a significant decrease of decorin positive area in astrocyte depleted animals compared to their controls (<b>F</b>). …”

MmuPV1 integration, host gene expression, and cell growth. by Lulu Yu (737362)

“…<b>B and C,</b> Expression of MmuPV1 E6E7 (green) correlates with a decrease in the expression of mouse Krt10 and Fabp5 (red) in the tail tumor tissues of FoxN1^nu/nu at day 21 as measured by RNA ISH using dual immunofluorescence RNAscope analysis. …”

Table_2_The Impact of the COVID-19 Pandemic on Women’s Reproductive Health.docx by Niamh Phelan (10450682)

“…</p>Results<p>1031 women completed the survey. Mean age was 36.7 ± 6.6 years (range, 15–54). 693/70% reported recording their cycles using an app or diary. 233/23% were using hormonal contraception. 441/46% reported a change in their menstrual cycle since the beginning of the pandemic. 483/53% reported worsening premenstrual symptoms, 100/18% reported new menorrhagia (p = 0.003) and 173/30% new dysmenorrhea (p < 0.0001) compared to before the pandemic. 72/9% reported missed periods who not previously missed periods (p = 0.003) and the median number of missed periods was 2 (1–3). 17/21% of those who “occasionally” missed periods pre-pandemic missed periods “often” during pandemic. 467/45% reported a reduced libido. …”

Table_2_The Impact of the COVID-19 Pandemic on Women’s Reproductive Health.docx by Phelan Niamh (10342460)

“…</p>Results<p>1031 women completed the survey. Mean age was 36.7 ± 6.6 years (range, 15–54). 693/70% reported recording their cycles using an app or diary. 233/23% were using hormonal contraception. 441/46% reported a change in their menstrual cycle since the beginning of the pandemic. 483/53% reported worsening premenstrual symptoms, 100/18% reported new menorrhagia (p = 0.003) and 173/30% new dysmenorrhea (p < 0.0001) compared to before the pandemic. 72/9% reported missed periods who not previously missed periods (p = 0.003) and the median number of missed periods was 2 (1–3). 17/21% of those who “occasionally” missed periods pre-pandemic missed periods “often” during pandemic. 467/45% reported a reduced libido. …”

Table_1_The Impact of the COVID-19 Pandemic on Women’s Reproductive Health.docx by Niamh Phelan (10450682)

“…</p>Results<p>1031 women completed the survey. Mean age was 36.7 ± 6.6 years (range, 15–54). 693/70% reported recording their cycles using an app or diary. 233/23% were using hormonal contraception. 441/46% reported a change in their menstrual cycle since the beginning of the pandemic. 483/53% reported worsening premenstrual symptoms, 100/18% reported new menorrhagia (p = 0.003) and 173/30% new dysmenorrhea (p < 0.0001) compared to before the pandemic. 72/9% reported missed periods who not previously missed periods (p = 0.003) and the median number of missed periods was 2 (1–3). 17/21% of those who “occasionally” missed periods pre-pandemic missed periods “often” during pandemic. 467/45% reported a reduced libido. …”

Image_1_Different Renal Function Patterns in Patients With Acute Heart Failure: Relationship With Outcome and Congestion.jpeg by Alberto Palazzuoli (12203753)

“…</p>Results<p>We recruited 467 subjects with a mean congestion score of 3.5±1.08 and a median creatinine value of 1.28 (1.00–1.70) mg/dl, eGFR 50 (37–65) ml/min/m² and NTpro B-type natriuretic peptide (BNP) 7,000 (4,200–11,700) pg/ml. …”

Table_1_The Impact of the COVID-19 Pandemic on Women’s Reproductive Health.docx by Phelan Niamh (10342460)

“…</p>Results<p>1031 women completed the survey. Mean age was 36.7 ± 6.6 years (range, 15–54). 693/70% reported recording their cycles using an app or diary. 233/23% were using hormonal contraception. 441/46% reported a change in their menstrual cycle since the beginning of the pandemic. 483/53% reported worsening premenstrual symptoms, 100/18% reported new menorrhagia (p = 0.003) and 173/30% new dysmenorrhea (p < 0.0001) compared to before the pandemic. 72/9% reported missed periods who not previously missed periods (p = 0.003) and the median number of missed periods was 2 (1–3). 17/21% of those who “occasionally” missed periods pre-pandemic missed periods “often” during pandemic. 467/45% reported a reduced libido. …”

Image_2_Different Renal Function Patterns in Patients With Acute Heart Failure: Relationship With Outcome and Congestion.jpeg by Alberto Palazzuoli (12203753)

“…</p>Results<p>We recruited 467 subjects with a mean congestion score of 3.5±1.08 and a median creatinine value of 1.28 (1.00–1.70) mg/dl, eGFR 50 (37–65) ml/min/m² and NTpro B-type natriuretic peptide (BNP) 7,000 (4,200–11,700) pg/ml. …”

Effect of OWB extract and CA on pro-inflammatory and anti-inflammatory cytokine release in LPS-induced peritoneal macrophages by sandwich ELISA and RT-PCR. by Durbadal Ojha (475076)

“…<p>Peritoneal macrophages were cultured overnight and incubated with LPS (1 µg/ml), washed after 4 h and then treated with the OWB (50 or 100 µg/m) or CA (10 µg/ml). The cells were further incubated for 24 h, and the cell-free supernatants were subjected to sandwich ELISA to determine the level of (A) TNF-α, (C) IL-1β, (E) IL-6 and (G) IL-6 (pg/mL). …”

TbCDC34 activity is modulated by compound CC0651. by Federico Rojas (480253)

“…Samples treated with CC0651 showed a decrease of cells with 1N1K and an increase of cells with 2N2K. …”

Electroretinography in NCBE-deficient mice indicates ON bipolar cell dysfunction. by Gerrit Hilgen (128467)

“…<p><i>A, D,</i> Representative single flash ERG recordings from NCBE WT (black) and KO (red) mice (age 12 months) for increasing intensities under dark-adapted (<b><i>A</i></b>, scotopic) and light-adapted (<b><i>D</i></b>, photopic) conditions. …”

mDia1 and mDia3 are dominantly expressed in Sertoli cells and indispensable for spermatogenesis. by Satoko Sakamoto (5793446)

“…<p>(A) PAS-stained stage VIII seminiferous tubule sections from adult WT and <i>mDia1/3</i> DKO mice. …”