The proteasome inhibitor Bortezomib inhibits not only FANC signaling, but also HR, Alt-EJ, and end resection. by Sean M. Howard (687174)

“…U2OS cells were treated with Bortezomib (100 nM, 4 hr before IR treatment) or vehicle (DMSO) as well as with an individual FANCA siRNA (siFANCA-3) or non-targeting siRNA (siCTRL). …”

Effect of shear, TFPI-coating concentration and FVIIa concentration in MDA-MB-231 adhesion to protein-immobilized channels under shear. by Sara P. Y. Che (718192)

“…</b> Microfluidic channels were immobilized with 100μg/mL TFPI, and MDA-MB-231 cells (pretreated with 10nM or 100nM FVIIa, and 10nM FX) were introduced at a range of shear stresses (0.35–1.3dyn/cm²). …”

Deletion of <i>Wwox</i> results in defective mammary branching and lobuloalveolar development. by Brent W. Ferguson (167494)

“…<p>(A–B) Representative microphotographs obtained from whole mounts of 12 week virgin <i>BK5 Wwox WT</i> (A) and <i>KO</i> (B) mammary glands. …”

In the dark, <i>nob</i> mice GCs oscillate asynchronously, but light stimulation synchronizes their oscillations. by Beerend H. J. Winkelman (7377299)

“…(Bi) Each trace shows the mean normalized GC activity of 100 episodes of activity in the dark during the first 2 s of a 5-s window. …”

The sequence between nt. 626/640 mediates both TPA-dependent activation and the negative regulation by T3/TR. by Hiroko Misawa (335240)

“…The stimulatory effect by TPA is decreased in MA. In the presence or absence of TPA (100 ng/ml), pBL-FFL-CAT5 (WT) or its mutants (MA-D) were transfected into CV1 cells. …”

Abnormal HRV responses after postural change in pSS patients by Fin ZJ Cai (51289)

“…However, between 2 and 5 minutes after standing, there was a relative decline in SBP in pSS patients and a relative increase in control individuals (= 0.015). …”

Long-term dexamethasone treatment inhibits the induction of <i>ANGPTL4</i> transcription, together with down-regulation of the GR. by Masafumi Nakamoto (3617828)

“…For LTDT, HepG2 cells were initially cultured in DMEM medium supplemented with 10% DCC-treated FBS and 100 nM dexamethasone (Dex) for 14 days. Black arrows show sampling times. …”

Supplementary Material for: The HDM2 (MDM2) Inhibitor NVP-CGM097 Inhibits Tumor Cell Proliferation and Shows Additive Effects with 5-Fluorouracil on the p53-p21-Rb-E2F1 Cascade in... by Reuther C. (3593810)

“…Incubation of GOT1 cells with NVP-CGM097 at 100, 500, and 2,500 nM for 96 h caused a significant decline in cell viability to 84.9 ± 9.2% (<i>p</i> < 0.05), 77.4 ± 6.6% (<i>p</i> < 0.01), and 47.7 ± 9.2% (<i>p</i> < 0.01). …”

Cardiovascular genes are dysregulated in FVB/N KLF2−/− AV region. by Aditi R. Chiplunkar (282141)

“…(<b>A–C</b>) In E10.5 FVB/N KLF2−/− AV region there is significantly decreased expression of (<b>A</b>) Tbx5 (p = 0.0175), (<b>B</b>) Gata4 (p = 0.0164) and (<b>C</b>) Sox9 (p = 0.019) mRNA compared to FVB/N WT, but Mix WT and Mix KLF2−/− hearts have no differences in expression of these genes. …”

ZNF202 is involved in <i>AMACR</i> gene regulation in HCT 116 cells. by Xiang Zhang (19800)

“…<p>A: The ³²P labeled wild type (WT) probe corresponds to a sequence containing CG12-16 and its flanking regions (<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1000334#pgen-1000334-t005" target="_blank">Table 5</a>). …”

Essential role of Sema4D in estrogen-mediated vaginal apoptosis. by Takuji Ito (566032)

“…OVX-oil treatment of WT mice significantly decreases apoptotic cell number in 5-week-old vaginal epithelia relative to that in Sham; compared with OVX-oil treatment, OVX-E2 treatment of WT mice induces a significant increase in apoptotic cell number in 5-week-old vaginal epithelia, comparable to the level of Sham. …”

Effects of STAT3 decoy oligonucleotide on the proliferation, apoptosis, and migration of HUVECs and HDMECs<i>in vitro</i>. by Jonah D. Klein (505754)

“…<p>(A) HUVECs and (B) HDMECs were transfected with the STAT3 decoy oligonucleotide or mutant control oligonucleotide at 0 nM to 1000 nM. …”

Late Mesozoic tectonic affinity of the Tengchong Block and southward extension of the Bangong-Nujiang Suture: constraints from Early Cretaceous granitic rocks in western Yunnan, SW... by Chen Wang (88408)

“…The Na-rich granodiorites have elevated Na₂O/K₂O ratios and Na₂O contents of 1.19–2.04 and 3.12–3.47 wt.%, respectively. These granodiorites also have relatively high Mg^# values and the transition metal element Cr of 53.3–54.5 and up to 100 ppm, respectively. …”

Simultaneous increase in canonical Wnt signaling and suppression of pAKT result in increased apoptosis of CC cells. by Michael Bordonaro (340595)

“…Cells were exposed for 8 or 17 hrs to mock treatment (M), 5 mM butyrate (B), butyrate and 5 µM MK2206 (BMK), 100 nm LBH589 (L), or 100 nm LBH589 and 5 µM MK2206 (LMK). …”

Lack of oligodendrocytes after DTA-mediated ablation of <i>C1ql1</i>-expressing OPCs. by Shayan Moghimyfiroozabad (19066182)

“…Higher magnification of the coronal sections in the center and lateral parts of CC and cortex shows the dramatic reduction in the density of OLs (CC1^pos GFP^pos cells, yellow arrowhead) in <i>C1ql1</i>^<i>Cre</i><i>; Sox10</i>^<i>DTA</i> mice at P16. Scale bars = 100 μm. Quantification shows a massive decrease in OL density in the <i>C1ql1</i>^<i>pos</i> OPC-ablated brains. …”

Adhesion of Als5 to collagen type IV involves recognition of carbohydrate residues on collagen type IV but is not solely determined by it. by Mohammad Faiz Ahmad (172608)

“…(B) Treatment of collagen type IV with N-Glycosidase F results in decrease in adherence of GST-Als5. Collagen type IV (100 µl; 1 mg/ml) was immobilised overnight at 4^oC in 96-well ELISA plate. …”

PRMT5 inhibition drives global transcriptomic changes in canine lymphoma. by Shelby L. Sloan (10803222)

“…(F) qRT-PCR analysis of <i>TP3I3</i> confirmed a decrease in transcript in CLBL-1 after a two day treatment with C220 (100 nM) compared to the 0 nM DMSO control (*<i>p < 0</i>.…”

Image_2_Light intensity changes and UVB radiation affect peridinin content and antioxidant activity in the Cassiopea andromeda holobiont.jpeg by Holger Kühnhold (6499133)

“…</p>Materials and Methods<p>Indoor bred C. andromeda specimens were exposed to five different PAR intensities (50, 100, 200, 400 and 800 µmol photons m⁻² s⁻¹) and a combined treatment of narrow-band UVB (λ = 285 ± 10 nm) radiation and intermediate (200 µmol photons m⁻² s⁻¹) PAR intensity over a period of four weeks. …”

Image_1_Light intensity changes and UVB radiation affect peridinin content and antioxidant activity in the Cassiopea andromeda holobiont.jpeg by Holger Kühnhold (6499133)

“…</p>Materials and Methods<p>Indoor bred C. andromeda specimens were exposed to five different PAR intensities (50, 100, 200, 400 and 800 µmol photons m⁻² s⁻¹) and a combined treatment of narrow-band UVB (λ = 285 ± 10 nm) radiation and intermediate (200 µmol photons m⁻² s⁻¹) PAR intensity over a period of four weeks. …”

miRNA-524-5p was target of nifedipine and regulated the expression of BRI3. by Dong-Qing Guo (667396)

“…P<0.05, 1-way ANOVA. d) Overexpression of miRNA-524-5p could indirectly decrease the expression of BRI3 gene. i) MDA-MB-231 cells were transfected with miRNA-524-5p mimics and negative control (both 100 nM) for 24h. …”