Response of ERK phosphorylation to cetuximab treatment stratified <i>KRAS</i> mutants into two groups ex vivo. by Takahiro Tashiro (827031)

“…Reconstituted spheroids were treated with or without 100 nM cetuximab for 2 h and then stimulated with or without 10 ng/ml EGF for 15 min. …”

Effect of treatment of mature biofilms with tobramycin (A) or meropenem (B). by Claudia Udine (224213)

“…Treatment of the mutants resulted in significantly higher reductions than treatment of the WT (p<0.05). In addition, supplementation resulted in a significant decrease in susceptibility compared to the unsupplemented mutant (p<0.05).…”

Effects of Emulsion Formulations of Oleuropein Isolated from Ethanol Extract of Olive Leaf in Diabetic Rats by AHMET G. AGGUL (10365323)

High-contrast images of unstained baculoviure obtained by our new measurement method. by Toshihiko Ogura (131016)

“…The resolution of the deconvolution image is 5 nm. Scale bars: (A), (C) and (D) 100 nm, (B) and (E) 50 nm.…”

Roles of individual genetic factors during repair of DSBs with non-cohesive ends generated by co-expression of I-SceI with Trex2. by Nicole Bennardo (93380)

“…Asterisks denote a statistical difference from EV (p<0.0001), and the dagger denotes a statistical difference from WT (p<0.0001). (B) Trex2 expression causes a decrease in HDR in cells deficient in Nbs1 and Brca1, but an increase in HDR in cells deficient in Xrcc4 and Msh2. …”

Overlap between apo and holo populations of LTPs can influence their transport rates. by Sriraksha Srinivasan (7535654)

“…<b>(b)</b> Mutations of GRAMD1A (5P), CPTP (V158N), and PITPA (P78L) that decrease their transport rates in vitro also reduce the similarities between apo and holo distributions. …”

Mutation of S and T residues in the third intracellular loop increases intracellular cAMP. by Katie M. Lowther (427408)

“…The densitometric value for surface GPR3 was divided by the densitometric value for total GPR3 expression and normalized to β-actin to compare the amount of GPR3 at the surface vs. total GPR3 (<b>E</b>). (*) indicates a significant decrease in surface expression of GPR3 mutants compared to “WT”. …”

NK cells are affected differently by allogeneic grafts depending on the course of rejection. by Oliver Beetz (6786137)

“…Syngeneic HTx served as a control group (n = 5). (B) Flow cytometric assessment of frequencies of NK cells in Lew wt and Lew.1a recipients after syngeneic and allogeneic HTx compared to naïve rats, respectively. …”

TK1 protein levels do not reflect p-ERK attenuation following inhibition of ^V600EBRAF inhibition in COLO 205 cells. by Eliot T. McKinley (390272)

“…<p>COLO 205 cells were collected 48 hours of PLX 4032 exposure at 10 nM, 100 nM, 500 nM, 1 µM, or 5 µM. (<b>A</b>) Western blot analysis demonstrated target inhibition of p-MEK despite increased p-ERK levels. …”

<i>β-cat</i>^<i>S-/</i>- mutants demonstrate altered Wnt9b signaling to the condensing mesenchyme. by Felix J. Boivin (710296)

“…(A-F) In contrast to <i>WT</i> at E15.5, the number of Pax2 and Six2 positive cells in the condensing mesenchyme was reduced in <i>β-cat</i>^<i>S-/</i>- kidneys. …”

Minimal photobleaching of mbYFPQS occurs with repeated photo-stimulation. by Spencer D. Watts (327115)

“…<p>A. A cultured midbrain neuron expressing mbYFPQS was imaged with an exposure of 100 ms every 5 s for 35 min with less than 6% decrease in baseline fluorescence. …”

HIV Tat activates platelets <i>in vivo.</i> by Donna C. Davidson (294540)

“…Upon injection with HIV Tat (100 ng/g body weight; n = 5), there is a significant increase in the level of each of these platelet-derived mediators in the plasma after 1 h, indicating that Tat stimulates platelets <i>in vivo</i>. …”

AKT2 regulated N-myc expression. by Jingbo Qiao (382330)

“…They were then treated with either GRP (100 nM) or IGF-1 (100 nM) for 2 h. Western blotting showed suppression of N-myc by siAKT2 despite stimulation with GRP or IGF-1. …”

The effect of Andro alone or in combination with Taxi on MMP loss in HeLa cells. by Mazen Alzaharna (3737878)

“…(E) A representative flow cytometric histograms showing the loss in MMP (decrease in FL2 fluorescence) in HeLa cells treated with 50 μM Andro and/or 100 μM Taxi for 24 or 48 h and stained with JC-1. …”

The Influence of the Platinum Weight Percentage in the Catalyst Formulation on the Performance of a High Temperature Ethanol Electroreformer Based on H3PO4 Doped Polybenzimidazole... by Bruno G. C. Alves (14005656)

Relative membrane levels of endogenous endoglin in HMEC-1 cells upon transient or stable mutant protein expression. by Tassilo Förg (606727)

“…Cells expressing the variant endoglin^ΔC (DC, without cytoplasmic domain) showed a 1.5 times higher ectopic expression than endoglin^wt.…”

Data_Sheet_1_Cathelicidin and Calprotectin Are Disparately Altered in Murine Models of Inflammatory Arthritis and Airway Inflammation.PDF by Mahadevappa Hemshekhar (601882)

“…CRAMP, S100A8, and S100A9 abundance were significantly elevated in the joint tissues of CIA mice, whereas these were decreased in the lung tissues of HDM-challenged mice, compared to naïve. …”

PIN1 endocytosis is inhibited in the lobe region by the ROP2 pathway in PCs. by Shingo Nagawa (173932)

“…Coexpressing CA-ROP2 suppressed both vesicle formation and decrease of PM signal in <i>rop4 R2i</i> cells (<i>n</i> = 5). …”

Hand1 downregulates <i>Ihh</i> and <i>Runx2</i> expression <i>in vivo</i>. by Lindsay E. Laurie (2504281)

“…(D) Expression of Ihh (a,b) and Runx2 (c,d) was detected by immunohistochemistry of E16.5 Wt (a) and <i>Hand1</i> mutant (b) femurs. …”

DOR binding is enhanced by CB₁R ligands in membranes of cells expressing CB₁R and DOR. by Ittai Bushlin (191060)

“…<b>B,</b> Membranes from N2A-DOR cells in which CB₁R expression was decreased by siRNA transfection were treated with 100 fM – 10 µM Hu-210 in the presence of 0.5 nM [³H]DPDPE. …”