Anticancer Activity Expressed by a Library of 2,9-Diazaperopyrenium Dications by Karel J. Hartlieb (1367880)

“…Although many promising chemotherapeutics have been developed upon the basis of polyaromatic DNA intercalating systems, these candidates did not proceed past clinical trials on account of their dose-limiting toxicity. Herein, we discuss an alternative, water-soluble class of polyaromatic compounds, the 2,9-diazaperopyrenium dications, and report <i>in vitro</i> cell studies for a library of these dications. …”

Anticancer Activity Expressed by a Library of 2,9-Diazaperopyrenium Dications by Karel J. Hartlieb (1367880)

“…Although many promising chemotherapeutics have been developed upon the basis of polyaromatic DNA intercalating systems, these candidates did not proceed past clinical trials on account of their dose-limiting toxicity. Herein, we discuss an alternative, water-soluble class of polyaromatic compounds, the 2,9-diazaperopyrenium dications, and report <i>in vitro</i> cell studies for a library of these dications. …”

Anticancer Activity Expressed by a Library of 2,9-Diazaperopyrenium Dications by Karel J. Hartlieb (1367880)

“…Although many promising chemotherapeutics have been developed upon the basis of polyaromatic DNA intercalating systems, these candidates did not proceed past clinical trials on account of their dose-limiting toxicity. Herein, we discuss an alternative, water-soluble class of polyaromatic compounds, the 2,9-diazaperopyrenium dications, and report <i>in vitro</i> cell studies for a library of these dications. …”

Anticancer Activity Expressed by a Library of 2,9-Diazaperopyrenium Dications by Karel J. Hartlieb (1367880)

“…Although many promising chemotherapeutics have been developed upon the basis of polyaromatic DNA intercalating systems, these candidates did not proceed past clinical trials on account of their dose-limiting toxicity. Herein, we discuss an alternative, water-soluble class of polyaromatic compounds, the 2,9-diazaperopyrenium dications, and report <i>in vitro</i> cell studies for a library of these dications. …”

Nicotinic acetylcholine receptors (nAChRs) are expressed in Trpm5 positive taste receptor cells (TRCs) by Jie Qian (565984)

“…Giving ethanol (5%) in drinking water to WT mice induced an increase in the expression of α5 and β4 mRNAs in circumvallate TRCs with a significant decrease in the expression of α3, α6 and β2 mRNAs. …”

CYP3A94 activity is significantly increased in V79-CYP3A94/DD-POR cells, but decreases after incubation with Shield-1. by Ramona Dettwiler (664360)

DALYs for different types of cancers in Iran, 2019, a) Men; b) Women. by Mitra Darbandi (17967619)

Sensitizing the lungs with <i>Kdm5b</i>^f/f-CD11c-Cre⁺ DCs prior to infection results in decreased pathology following RSV challenge. by Catherine Ptaschinski (756139)

Dietary or gavaged TU-100 and the ginger component decrease enteropooling stimulated by anti-CD3 antibody treatment in specified pathogen free (SPF) and germ free (GF) C57Bl6 mice. by Nobuhiro Ueno (346397)

Spontaneous physical activity and respiratory quotient (RQ) in WT and NMIIC KO mice. by Hiroki Hamaguchi (22783780)

TRIAC, T4 and T3 content in the cerebral cortex in vehicle treated Wt (TRIAC n = 6; T4 n = 5 and T3 n = 5) and <i>Mct8</i>KO mice (<i>Mct8</i>KO+veh; TRIAC n = 7; T4 n = 7 and T3 n... by Soledad Bárez-López (607514)

Oxytocin decreases postsynaptic CeA spontaneous GABAergic transmission and blocks presynaptic alcohol effects. by Brendan J. Tunstall (6593357)

“…(A, Bottom) Oxytocin decreased sIPSC amplitude from baseline in CeA neurons from both nondependent and dependent rats and caused a small increase from baseline in sIPSC rise time in nondependent rats. …”

(R+S) and (R)-albuterol decrease NF-κB activity by Marcela A Ferrada (41716)

“…After transfection, (R)-albuterol (R), (S)-albuterol (S), or racemic albuterol (R+ S) were added to cells pre-activated with (ConA, 5 μg/ml) and (PMA, 100 ng/ml) (CP) and then treated with (R)-, (S)-, or (R+S)-albuterol (Fig. 6). …”

B cell-deficient μMT mice exhibit diminished lung infiltrates relative to WT C56BL/6’s in chronic TB. by Yong Chen (109188)

Five genes involved in piRNA biosynthesis were commonly down-regulated in the two <i>enok</i> mutants as compared with the WT control, while the expression levels of <i>piwi</i>, <i>AGO3</i> and <i>aub</i> were not decreased in <i>enok</i> mutants. by Shih-Ying Tsai (3576587)

Fig 5 - by Rabeya Binta Alam (17364707)

<i>Prep1</i>^-/- ES cells express decreased levels of Pbx1 and Pbx2 proteins but not of their RNA. by Audrey Laurent (129711)

Competitive DNA fragment containing the A allele decreased MMP3-A’s binding with transcription factor. by Cong Huai (385128)

Dimerization of [Fe^III(bpy)₃]³⁺ in Aqueous Solutions: Elucidating a Mechanism Based on Historical Proposals, Electrochemical Data, and Computationa... by Nicolas E. Holubowitch (9254254)

“…Despite these favorable characteristics, its oxidized Fe­(III) form undergoes dimerization to form μ-O-[Fe^III(bpy)₂(H₂O)]₂⁴⁺, leading to a dramatic ∼0.7 V decrease during battery discharge. …”

Decreased representation of primitive endoderm (PE) cells in E.4.5 <i>Prep1</i>^-/- mouse embryos. by Audrey Laurent (129711)