Image_4_Periplasmic Expression of 4/7 α-Conotoxin TxIA Analogs in E. coli Favors Ribbon Isomer Formation – Suggestion of a Binding Mode at the α7 nAChR.png by Yamina El Hamdaoui (6759080)

“…Two-electrode voltage clamp analysis on oocyte-expressed nAChR subtypes demonstrated the functionality of these peptides but also revealed a 30 to 100-fold potency decrease of expressed TxIA compared to chemically synthesized TxIA. …”

Image_2_Periplasmic Expression of 4/7 α-Conotoxin TxIA Analogs in E. coli Favors Ribbon Isomer Formation – Suggestion of a Binding Mode at the α7 nAChR.JPEG by Yamina El Hamdaoui (6759080)

“…Two-electrode voltage clamp analysis on oocyte-expressed nAChR subtypes demonstrated the functionality of these peptides but also revealed a 30 to 100-fold potency decrease of expressed TxIA compared to chemically synthesized TxIA. …”

Image_1_Periplasmic Expression of 4/7 α-Conotoxin TxIA Analogs in E. coli Favors Ribbon Isomer Formation – Suggestion of a Binding Mode at the α7 nAChR.JPEG by Yamina El Hamdaoui (6759080)

“…Two-electrode voltage clamp analysis on oocyte-expressed nAChR subtypes demonstrated the functionality of these peptides but also revealed a 30 to 100-fold potency decrease of expressed TxIA compared to chemically synthesized TxIA. …”

Image_3_Periplasmic Expression of 4/7 α-Conotoxin TxIA Analogs in E. coli Favors Ribbon Isomer Formation – Suggestion of a Binding Mode at the α7 nAChR.JPEG by Yamina El Hamdaoui (6759080)

“…Two-electrode voltage clamp analysis on oocyte-expressed nAChR subtypes demonstrated the functionality of these peptides but also revealed a 30 to 100-fold potency decrease of expressed TxIA compared to chemically synthesized TxIA. …”

8-Propyl-6H-[1,3]dioxolo[4,5-g]chromen-6-one: A new coumarin with monoamine oxidase B inhibitory activity and possible anti-parkinsonian effects by María del Pilar Olaya (12848792)

“…FCS303 inhibited monoamine oxidase B (MAO-B) with an IC50 of 5.46 ± 0.36 µM; however, there was no effect on monoamine oxidase A (MAO-A). The oral administration of FCS303 led to a significant reversal of hypokinesia in the reserpine model (at 24 h, doses of 100 and 200 mg/kg) and in the levodopa/carbidopa potentiation assay (at 2 and 24 h, dose of 200 mg/kg). …”

Data Sheet 1_Global burden of ischemic heart disease attributable to ambient and household PM2.5 exposure: a comprehensive analysis (1990–2021) from socioeconomics perspective.pdf... by Chenran Zhang (4443106)

“…</p>Results<p>From 1990 to 2021, age-standardized rates (ASMR, ASDR) of IHD attributable to ambient PM_2.5 declined to 20.85 per 100,000 (AAPC = −0.7), with attributable to household PM_2.5 decreased to 9.02 per 100,000 (AAPC = −2.49). …”

Supplementary file 1_Global, regional, and national burden of iodine deficiency for women of reproductive age, 1990–2021: a systematic analysis based on the Global Burden of Diseas... by Taotao Wang (115296)

“…</p>Methods<p>Utilizing data from the Global Burden of Disease Study 2021, this study reports age-standardized rates per 100,000 population and average annual percentage changes (AAPCs) in incidence, prevalence, and years lived with disability (YLD) of iodine deficiency among WRA, facilitating a comparative analysis of the burden across regions and nations. …”

Data_Sheet_1_Potential lipid-lowering effects of Ulmus macrocarpa Hance extract in adults with untreated high low-density lipoprotein cholesterol concentrations: A randomized doubl... by Ye Li Lee (14036589)

“…</p>Results<p>UME over 12 weeks led to a greater decrease in LDL-C, TC, and ApoB concentrations than did the placebo as follows: by 18.1 mg/dl (P < 0.001); 23.3 mg/dl (P < 0.001); 9.3 mg/dl (P = 0.018), respectively. …”

Immunofluorescence images from age-matched 3-month old Tg (A) and control (B) rats and from age-matched 7-month old Tg (C) and control (D) rats. by Margaret R. Lentz (364986)

“…Each row shows GFAP staining in yellow, NFH staining in Blue and a composite image of both (magnification 100X, scale bar = 40 µm). …”

Data_Sheet_1_Electroacupuncture for the Prevention of Postoperative Cognitive Dysfunction Among Older Adults Undergoing Hip and Knee Arthroplasty: A Systematic Review and Meta-Anal... by Liang Ou (73724)

“…<p>Background: Postoperative cognitive dysfunction (POCD) is a common surgical complication in elderly patients undergoing hip and knee replacement. …”

Data_Sheet_1_The Efficacy and Safety of Pirfenidone Combined With Immunosuppressant Therapy in Connective Tissue Disease-Associated Interstitial Lung Disease: A 24-Week Prospective... by Jiaqi Wang (369548)

“…However, in IIM patients with a non-UIP tendency, PFD displayed better therapeutic effects than the control (10.50 vs. 1.00%). …”

Fluoro-Ruby-labeled motoneurons at 13 weeks after immediate nerve repair (A), 1 months delayed repair (B), 3 months delayed repair (C) and 6 months delayed repair (D). by Samuel Jonsson (284555)

Immunostaining of nucleostemin (NS) (A–C), semi-quantitation (D) and qRT-PCR analysis of gene expression (E, F) in aging TSCs subjected to mechanical loading <i>in vitro</i>. by Jianying Zhang (256508)

“…<p>Patellar TSCs isolated from aging mice (9 months old) were subjected to no stretching (Control), 4% stretching or 8% stretching followed by the analyses. Immunostaining (<b>A–C</b>) and semi-quantitation (<b>D</b>) showed that compared to the control without stretching, 4% stretching increased the number of NS-expressing TSCs, whereas 8% stretching further decreased it. qRT-PCR analysis of the expression of three stem cell and tenocyte-related genes, Nanog, collagen I and tenomodulin (<b>E</b>) and three non-tenocyte related genes, LPL, Sox-9 and Runx-2 (<b>F</b>) showed that 4% stretching effectively up-regulated Nanog, collagen I and tenomodulin, but 8% was less effective (<b>E</b>). …”

Can Topical Insect Repellents Reduce Malaria? A Cluster-Randomised Controlled Trial of the Insect Repellent <i>N,N</i>-diethyl-<i>m</i>-toluamide (DEET) in Lao PDR by Vanessa Chen-Hussey (445411)

“…Intention to treat analysis found no effect from the use of repellent on malaria incidence (hazard ratio: 1.00, 95% CI: 0.99–1.01, p = 0.868). A higher socio-economic score was found to significantly decrease malaria risk (hazard ratio: 0.72, 95% CI: 0.58–0.90, p = 0.004). …”

DataSheet1_Effects of the peripheral CB1 receptor antagonist JD5037 in mono— and polytherapy with the AMPK activator metformin in a monocrotaline-induced rat model of pulmonary hyp... by Patryk Remiszewski (13594804)

“…Animals received metformin (100 mg/kg), JD5037 (3 mg/kg), or a combination of both once daily for 21 days. …”

Gastrointestinal cancer cells treatment with bevacizumab activates a VEGF autoregulatory mechanism involving telomerase catalytic subunit hTERT via PI3K-AKT, HIF-1α and VEGF recept... by Nadine Mahfouz (4097566)

“…</p><p>Methods</p><p>AGS (gastric cancer), Caco-2 (colorectal cancer) and HepG2/C3A (hepatocellular carcinoma), were treated with telomerase inhibitors BIBR-1232 (10μM) and costunolide (10μM), with bevacizumab (Avastin® at 5 ng/ml or 100μg/ml) or with a combination of both types of inhibitors. …”

Table 2_Effects of low-frequency and high-frequency electroacupuncture pretreatment on the COX-2/mPGES-1/PGE2 pathway in a rat model of cold-coagulation dysmenorrhea.docx by Yue Song (162328)

“…</p>Methods<p>A cold-coagulation type dysmenorrhea model was established in rats, which were divided into the control group, model group, low-frequency electroacupuncture group (2/10 Hz), and high-frequency electroacupuncture group (20/100 Hz). …”

Table 4_Effects of low-frequency and high-frequency electroacupuncture pretreatment on the COX-2/mPGES-1/PGE2 pathway in a rat model of cold-coagulation dysmenorrhea.docx by Yue Song (162328)

“…</p>Methods<p>A cold-coagulation type dysmenorrhea model was established in rats, which were divided into the control group, model group, low-frequency electroacupuncture group (2/10 Hz), and high-frequency electroacupuncture group (20/100 Hz). …”

Table 3_Effects of low-frequency and high-frequency electroacupuncture pretreatment on the COX-2/mPGES-1/PGE2 pathway in a rat model of cold-coagulation dysmenorrhea.xlsx by Yue Song (162328)

“…</p>Methods<p>A cold-coagulation type dysmenorrhea model was established in rats, which were divided into the control group, model group, low-frequency electroacupuncture group (2/10 Hz), and high-frequency electroacupuncture group (20/100 Hz). …”

Table 1_Effects of low-frequency and high-frequency electroacupuncture pretreatment on the COX-2/mPGES-1/PGE2 pathway in a rat model of cold-coagulation dysmenorrhea.xlsx by Yue Song (162328)

“…</p>Methods<p>A cold-coagulation type dysmenorrhea model was established in rats, which were divided into the control group, model group, low-frequency electroacupuncture group (2/10 Hz), and high-frequency electroacupuncture group (20/100 Hz). …”