Competitive tuning: Competition's role in setting the frequency-dependence of Ca²⁺-dependent proteins by Daniel R. Romano (4574287)

“…In this work, we view Ca²⁺/CaM as a limiting resource in the signal transduction pathway owing to its low abundance relative to its binding partners. …”

Oligodendrocyte ablation affects synapse formation and remodeling at P1. by Sandrine Doretto (221560)

“…Insets (scale bar 12.5 µm) show NR1 localization on PC soma and dendrites in the WT whereas in MBP-TK mice NR1 staining appears internalized. …”

Diadinoxanthin (Ddx) concentration and de-epoxidation state (DES). by Benjamin Schellenberger Costa (461158)

“…O: no significant difference between WT and aureochrome 1a silenced strain; −: significant decrease in aureochrome 1a silenced strain compared to WT; +: significant increase in aureochrome 1a silenced strain compared to WT.…”

Behavioral stress delays androgen ablation-induced prostate involution and apoptosis via β2-AR and BAD phosphorylation. by Sazzad Hassan (454373)

“…Intact calm mice (0c), numbers under the columns indicate days of bicalutamide treatment; BAD^wt/wt mice with wild type BAD; BAD^wt/wt +ICI, mice treated with ICI118,551; BAD^3SA/WT, mice with knockin on phosphorylation-deficient BAD3SA mutant (n = 3 to 5 in each group). …”

Supplementary Material for: Real-world effectiveness of piperacillin/tazobactam with and without linezolid for spontaneous bacterial peritonitis by Quickert S. (12023954)

“…Treatment failure, defined as the need to escalate antibiotic therapy due to in vitro resistance, lack of neutrophil decrease in ascitic fluid, or clinical decision, and 30-day survival were retrospectively assessed. …”

Supplementary Material for: Real-world effectiveness of piperacillin/tazobactam with and without linezolid for spontaneous bacterial peritonitis by Quickert S. (12023954)

“…Treatment failure, defined as the need to escalate antibiotic therapy due to in vitro resistance, lack of neutrophil decrease in ascitic fluid, or clinical decision, and 30-day survival were retrospectively assessed. …”

Table_1_Intratracheal inoculation results in Brucella-associated reproductive disease in male mouse and guinea pig models of infection.DOCX by Martha E. Hensel (6425414)

“…Vaccination resulted in a significant reduction in colonization in the mouse, but this could not be correlated with a decrease in inflammation. …”

The effect of Ingenol-B on the suppressive capacity of elite suppressor HIV-specific CD8+ T cells by Abena K. Kwaa (3997559)

“…<div><p>Background</p><p>Some latency-reversing agents (LRAs) inhibit HIV-specific CD8+ T cell responses. In a prior study of protein kinase C (PKC) agonists, we found that bryostatin-1 inhibited elite controller/suppressor (ES) CD8+ T cell suppressive activity whereas prostratin had no effect. …”

Alterations of Gene Expression and Glutamate Clearance in Astrocytes Derived from an MeCP2-Null Mouse Model of Rett Syndrome by Yasunori Okabe (170091)

“…When high extracellular Glu was added to the astrocyte cultures and incubated, a time-dependent decrease of extracellular Glu concentration occurred due to Glu clearance by astrocytes. …”

Overexpression of Sano results in smaller apical domains. by SeYeon Chung (256943)

“…WT (F). <i>btl-Gal4</i>-driven Sano-overexpressing trachea (G) reveal a significant decrease in apical domain size. …”

Changes in transepithelial electrical resistance (cTER) upon cAMP. by Natalia Molenda (580354)

“…Stimulation with 8cpt-cAMP caused a decrease of TER in CFBE-WT cells (blue triangles) and an increase for CFBE-delF (brown circles). …”

Transcriptome Analyses of a Salt-Tolerant Cytokinin-Deficient Mutant Reveal Differential Regulation of Salt Stress Response by Cytokinin Deficiency by Rie Nishiyama (49902)

“…WT-0 mM, <em>ipt1,3,5,7</em>-200 mM vs. <em>ipt1,3,5,7</em>-0 mM and <em>ipt1,3,5,7</em>-200 mM vs. …”

(A) Schematic presentation of the human AID protein sequence along with the positions of the lysine residues mutated in the various constructs by Said Aoufouchi (49316)

“…(B) BL2 clones expressing either WT-AID-EGFP (sample 1, WT), or a lysineless mutant of AID (Kzero-AID-EGFP; sample 2, Kzero) were incubated with the indicated inhibitors for 5 h. …”

The conserved motifs in the SBD of PluR and PauR are essential but not sufficient for ligand-binding specificity. by Sophie Brameyer (731567)

“…(<b>B</b>) and (<b>D</b>): The RLU values are depicted 2 h after the addition of the distinct signaling molecules, either 3.5 nM PPYD, 3.5 nM DAR or 100 nM C8-HSL. Reference line was set to 370 RLUs to compare better with <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0124093#pone.0124093.g002" target="_blank">Fig 2</a>.…”

MIA/CD-RAP activates the <i>p54^nrb</i> promoter via the transcription factor YBX1. by Rainer Schmid (496848)

“…<p>(<b>A</b>) YBX1 activity as measured using a reporter gene assay revealed a significant decrease in YBX1 promoter activity in MIA-/- mMSCs compared with WT mMSCs (III) (**p<0.01). …”

Abberant α-Synuclein Confers Toxicity to Neurons in Part through Inhibition of Chaperone-Mediated Autophagy by Maria Xilouri (264240)

“…</p><h3>Methods and Findings</h3><p>Novel inducible SH-SY5Y and PC12 cell lines expressing human WT and A53T ASYN, as well as two mutant forms that lack the CMA-targeting motif were generated. …”

Proliferation of CTS-treated cells. by Rebecca J. Clifford (497197)

“…<p>A) Normal MCF10A cells exhibited a concentration-dependent decrease in BrdU incorporation (proliferation) when treated with 500 nM ouabain, 50 nM bufalin or 100 nM bufalin for 2 hours (p<0.01). …”

CV1720 cells show impaired ATR–dependent DNA damage responses. by Tomoo Ogi (122258)

“…<p>A) WT, DK0064 (ATR–SS), CV1720 (patient), CV1780 (patient's mother) and CV1783 (patient's father) cells were exposed to 5 Jm⁻² UV and the mitotic index (MI) assessed 2 h post exposure. …”

Land cover, more than monthly fire weather, drives fire-size distribution in Southern Québec forests: Implications for fire risk management by Jean Marchal (3319485)

“…Fires were highly selective on fuel-type under a wide range of fire weather conditions: specifically, deciduous forest, lakes and to a lesser extent recently burned areas decreased the expected fire size in their vicinity compared to conifer forest. …”

Data_Sheet_1_Health Effects of Metabolic Risks in the United States From 1990 to 2019.docx by Ruifang Chen (2451214)

“…</p>Results<p>In 2019, the age-standardized death and DALY rates attributable to metabolic risks were 174.9 and 4738.7 per 100,000 people, accounting for 33.1% and 18.2% of death and DALY rates from all causes in the US, and there was a decrease by −32.5% and −21.2% in age-standardized death and DALY rates since 1990. …”