DataSheet2_Multi-omics analyses reveal ClpP activators disrupt essential mitochondrial pathways in triple-negative breast cancer.xlsx by Emily M. J. Fennell (6654536)

“…Notably, this included the downregulation of many mitochondrial processes and proteins, including mitochondrial translation and mitochondrial matrix proteins. We performed a large-scale transcriptomic analysis of WT SUM159 cells, identifying ∼7,700 transcripts (746 and 1,100 significantly increasing, 795 and 1,013 significantly decreasing in ONC201 and TR-57 treated cells, respectively). …”

Image1_Multi-omics analyses reveal ClpP activators disrupt essential mitochondrial pathways in triple-negative breast cancer.jpg by Emily M. J. Fennell (6654536)

“…Notably, this included the downregulation of many mitochondrial processes and proteins, including mitochondrial translation and mitochondrial matrix proteins. We performed a large-scale transcriptomic analysis of WT SUM159 cells, identifying ∼7,700 transcripts (746 and 1,100 significantly increasing, 795 and 1,013 significantly decreasing in ONC201 and TR-57 treated cells, respectively). …”

DataSheet6_Multi-omics analyses reveal ClpP activators disrupt essential mitochondrial pathways in triple-negative breast cancer.xlsx by Emily M. J. Fennell (6654536)

“…Notably, this included the downregulation of many mitochondrial processes and proteins, including mitochondrial translation and mitochondrial matrix proteins. We performed a large-scale transcriptomic analysis of WT SUM159 cells, identifying ∼7,700 transcripts (746 and 1,100 significantly increasing, 795 and 1,013 significantly decreasing in ONC201 and TR-57 treated cells, respectively). …”

Image4_Multi-omics analyses reveal ClpP activators disrupt essential mitochondrial pathways in triple-negative breast cancer.JPEG by Emily M. J. Fennell (6654536)

“…Notably, this included the downregulation of many mitochondrial processes and proteins, including mitochondrial translation and mitochondrial matrix proteins. We performed a large-scale transcriptomic analysis of WT SUM159 cells, identifying ∼7,700 transcripts (746 and 1,100 significantly increasing, 795 and 1,013 significantly decreasing in ONC201 and TR-57 treated cells, respectively). …”

DataSheet1_Multi-omics analyses reveal ClpP activators disrupt essential mitochondrial pathways in triple-negative breast cancer.xlsx by Emily M. J. Fennell (6654536)

“…Notably, this included the downregulation of many mitochondrial processes and proteins, including mitochondrial translation and mitochondrial matrix proteins. We performed a large-scale transcriptomic analysis of WT SUM159 cells, identifying ∼7,700 transcripts (746 and 1,100 significantly increasing, 795 and 1,013 significantly decreasing in ONC201 and TR-57 treated cells, respectively). …”

Image7_Multi-omics analyses reveal ClpP activators disrupt essential mitochondrial pathways in triple-negative breast cancer.JPEG by Emily M. J. Fennell (6654536)

“…Notably, this included the downregulation of many mitochondrial processes and proteins, including mitochondrial translation and mitochondrial matrix proteins. We performed a large-scale transcriptomic analysis of WT SUM159 cells, identifying ∼7,700 transcripts (746 and 1,100 significantly increasing, 795 and 1,013 significantly decreasing in ONC201 and TR-57 treated cells, respectively). …”

DataSheet4_Multi-omics analyses reveal ClpP activators disrupt essential mitochondrial pathways in triple-negative breast cancer.xlsx by Emily M. J. Fennell (6654536)

“…Notably, this included the downregulation of many mitochondrial processes and proteins, including mitochondrial translation and mitochondrial matrix proteins. We performed a large-scale transcriptomic analysis of WT SUM159 cells, identifying ∼7,700 transcripts (746 and 1,100 significantly increasing, 795 and 1,013 significantly decreasing in ONC201 and TR-57 treated cells, respectively). …”

DataSheet3_Multi-omics analyses reveal ClpP activators disrupt essential mitochondrial pathways in triple-negative breast cancer.xlsx by Emily M. J. Fennell (6654536)

“…Notably, this included the downregulation of many mitochondrial processes and proteins, including mitochondrial translation and mitochondrial matrix proteins. We performed a large-scale transcriptomic analysis of WT SUM159 cells, identifying ∼7,700 transcripts (746 and 1,100 significantly increasing, 795 and 1,013 significantly decreasing in ONC201 and TR-57 treated cells, respectively). …”

DataSheet7_Multi-omics analyses reveal ClpP activators disrupt essential mitochondrial pathways in triple-negative breast cancer.xlsx by Emily M. J. Fennell (6654536)

“…Notably, this included the downregulation of many mitochondrial processes and proteins, including mitochondrial translation and mitochondrial matrix proteins. We performed a large-scale transcriptomic analysis of WT SUM159 cells, identifying ∼7,700 transcripts (746 and 1,100 significantly increasing, 795 and 1,013 significantly decreasing in ONC201 and TR-57 treated cells, respectively). …”

Image2_Multi-omics analyses reveal ClpP activators disrupt essential mitochondrial pathways in triple-negative breast cancer.JPEG by Emily M. J. Fennell (6654536)

“…Notably, this included the downregulation of many mitochondrial processes and proteins, including mitochondrial translation and mitochondrial matrix proteins. We performed a large-scale transcriptomic analysis of WT SUM159 cells, identifying ∼7,700 transcripts (746 and 1,100 significantly increasing, 795 and 1,013 significantly decreasing in ONC201 and TR-57 treated cells, respectively). …”

Image6_Multi-omics analyses reveal ClpP activators disrupt essential mitochondrial pathways in triple-negative breast cancer.JPEG by Emily M. J. Fennell (6654536)

“…Notably, this included the downregulation of many mitochondrial processes and proteins, including mitochondrial translation and mitochondrial matrix proteins. We performed a large-scale transcriptomic analysis of WT SUM159 cells, identifying ∼7,700 transcripts (746 and 1,100 significantly increasing, 795 and 1,013 significantly decreasing in ONC201 and TR-57 treated cells, respectively). …”

Effect of glutamate (Glut) and 4-AP on CAPs in <i>ex vivo</i> spinal ventral columns. by Yan Fu (110146)

“…<p>(A) Histogram showing an irreversible increase in mean peak CAP amplitudes (normalized to 100% of the CAP amplitude (Pre) prior to glutamate treatment) after 1 mM glutamate treatment. …”

Sections of testis from 6 month old male medaka stained with H&E. by Hilary D. Miller (29470)

“…F: Animal exposed to 10.0 µg/L EE2 for 14 days has a severe thickening of the interstitium, increased vacuolization, and an overall decrease in germinal epithelium. …”

Replacement of chicken skin with canola oil in chicken nuggets by Sandra Tiemi Seó (16453032)

“…There was a decrease in AI (T0%-raw vs. T100%-fried, 0.39 vs. 0.10) and IT (T0%-raw vs. …”

<i>hGFAP-Cre</i> activity in the cerebellum. by Jing Wen (25059)

“…<p>Sagittal sections were shown. (A) Xgal staining in an E12.5 <i>hGFAP-Cre, R26R</i> mouse, showing the absence of Cre activity in the cerebellum. …”

The <i>Citrobacter rodentium</i> type III secretion system effector EspO affects mucosal damage repair and antimicrobial responses by Cedric N. Berger (4544008)

“…<i>rodentium</i>. This overlapped with a decrease in STAT3 phosphorylation in IECs. Importantly, while the reduced CCH and abundance of antimicrobial proteins during Δ<i>espO</i> infection did not affect <i>C</i>. …”

HIF1α deletion affects <i>in vivo</i> virus growth expansion during acute infection. by Darlah M. López-Rodríguez (8098544)

“…Virus replication was significantly decreased on day 5 (<i>P<0</i>.<i>012</i>) or day 7 <i>(P<0</i>.…”

EFFECT OF WATER DEFICIT AND ABSCISIC ACID ON PHOTOSYNTHETIC AND ANTIOXIDANT METABOLISM IN SEEDLINGS OF Calophyllum brasiliense (CAMBESS.) by Lucas Coutinho Reis (6511265)

“…The decrease in stomatal conductance was accompanied by a decrease in photosynthetic and transpiration rates, but seedlings treated with 10 µM ABA presented a higher photosynthetic rate than the remaining treatments under water deficit. …”

Angiogenic response in ischemic limbs. by Masayuki Kubo (298705)

“…Quantitative analysis revealed that the blood flow (B) and microvessel density (D) in the ischemic hindlimb significantly decreased in the HSF1-KO mice compared to the WT mice, 21 days after the induction of ischemia (n = 5 or 6 animals/group).…”

Muscle fiber CSAs of the soleus and EDL muscles in the GH-administered SDRs treated with dexamethasone, BCAA or both. by Hikaru Nishida (757003)

“…Dex-treated group. D. Dex elicited a decrease in the CSAs of the EDL muscles in the GH-treated SDRs. …”