Image3_Multi-omics analyses reveal ClpP activators disrupt essential mitochondrial pathways in triple-negative breast cancer.jpg by Emily M. J. Fennell (6654536)

“…Notably, this included the downregulation of many mitochondrial processes and proteins, including mitochondrial translation and mitochondrial matrix proteins. We performed a large-scale transcriptomic analysis of WT SUM159 cells, identifying ∼7,700 transcripts (746 and 1,100 significantly increasing, 795 and 1,013 significantly decreasing in ONC201 and TR-57 treated cells, respectively). …”

DataSheet2_Multi-omics analyses reveal ClpP activators disrupt essential mitochondrial pathways in triple-negative breast cancer.xlsx by Emily M. J. Fennell (6654536)

“…Notably, this included the downregulation of many mitochondrial processes and proteins, including mitochondrial translation and mitochondrial matrix proteins. We performed a large-scale transcriptomic analysis of WT SUM159 cells, identifying ∼7,700 transcripts (746 and 1,100 significantly increasing, 795 and 1,013 significantly decreasing in ONC201 and TR-57 treated cells, respectively). …”

Image1_Multi-omics analyses reveal ClpP activators disrupt essential mitochondrial pathways in triple-negative breast cancer.jpg by Emily M. J. Fennell (6654536)

“…Notably, this included the downregulation of many mitochondrial processes and proteins, including mitochondrial translation and mitochondrial matrix proteins. We performed a large-scale transcriptomic analysis of WT SUM159 cells, identifying ∼7,700 transcripts (746 and 1,100 significantly increasing, 795 and 1,013 significantly decreasing in ONC201 and TR-57 treated cells, respectively). …”

DataSheet6_Multi-omics analyses reveal ClpP activators disrupt essential mitochondrial pathways in triple-negative breast cancer.xlsx by Emily M. J. Fennell (6654536)

“…Notably, this included the downregulation of many mitochondrial processes and proteins, including mitochondrial translation and mitochondrial matrix proteins. We performed a large-scale transcriptomic analysis of WT SUM159 cells, identifying ∼7,700 transcripts (746 and 1,100 significantly increasing, 795 and 1,013 significantly decreasing in ONC201 and TR-57 treated cells, respectively). …”

Image4_Multi-omics analyses reveal ClpP activators disrupt essential mitochondrial pathways in triple-negative breast cancer.JPEG by Emily M. J. Fennell (6654536)

“…Notably, this included the downregulation of many mitochondrial processes and proteins, including mitochondrial translation and mitochondrial matrix proteins. We performed a large-scale transcriptomic analysis of WT SUM159 cells, identifying ∼7,700 transcripts (746 and 1,100 significantly increasing, 795 and 1,013 significantly decreasing in ONC201 and TR-57 treated cells, respectively). …”

DataSheet1_Multi-omics analyses reveal ClpP activators disrupt essential mitochondrial pathways in triple-negative breast cancer.xlsx by Emily M. J. Fennell (6654536)

“…Notably, this included the downregulation of many mitochondrial processes and proteins, including mitochondrial translation and mitochondrial matrix proteins. We performed a large-scale transcriptomic analysis of WT SUM159 cells, identifying ∼7,700 transcripts (746 and 1,100 significantly increasing, 795 and 1,013 significantly decreasing in ONC201 and TR-57 treated cells, respectively). …”

Image7_Multi-omics analyses reveal ClpP activators disrupt essential mitochondrial pathways in triple-negative breast cancer.JPEG by Emily M. J. Fennell (6654536)

“…Notably, this included the downregulation of many mitochondrial processes and proteins, including mitochondrial translation and mitochondrial matrix proteins. We performed a large-scale transcriptomic analysis of WT SUM159 cells, identifying ∼7,700 transcripts (746 and 1,100 significantly increasing, 795 and 1,013 significantly decreasing in ONC201 and TR-57 treated cells, respectively). …”

DataSheet4_Multi-omics analyses reveal ClpP activators disrupt essential mitochondrial pathways in triple-negative breast cancer.xlsx by Emily M. J. Fennell (6654536)

“…Notably, this included the downregulation of many mitochondrial processes and proteins, including mitochondrial translation and mitochondrial matrix proteins. We performed a large-scale transcriptomic analysis of WT SUM159 cells, identifying ∼7,700 transcripts (746 and 1,100 significantly increasing, 795 and 1,013 significantly decreasing in ONC201 and TR-57 treated cells, respectively). …”

DataSheet3_Multi-omics analyses reveal ClpP activators disrupt essential mitochondrial pathways in triple-negative breast cancer.xlsx by Emily M. J. Fennell (6654536)

“…Notably, this included the downregulation of many mitochondrial processes and proteins, including mitochondrial translation and mitochondrial matrix proteins. We performed a large-scale transcriptomic analysis of WT SUM159 cells, identifying ∼7,700 transcripts (746 and 1,100 significantly increasing, 795 and 1,013 significantly decreasing in ONC201 and TR-57 treated cells, respectively). …”

DataSheet7_Multi-omics analyses reveal ClpP activators disrupt essential mitochondrial pathways in triple-negative breast cancer.xlsx by Emily M. J. Fennell (6654536)

“…Notably, this included the downregulation of many mitochondrial processes and proteins, including mitochondrial translation and mitochondrial matrix proteins. We performed a large-scale transcriptomic analysis of WT SUM159 cells, identifying ∼7,700 transcripts (746 and 1,100 significantly increasing, 795 and 1,013 significantly decreasing in ONC201 and TR-57 treated cells, respectively). …”

Image2_Multi-omics analyses reveal ClpP activators disrupt essential mitochondrial pathways in triple-negative breast cancer.JPEG by Emily M. J. Fennell (6654536)

“…Notably, this included the downregulation of many mitochondrial processes and proteins, including mitochondrial translation and mitochondrial matrix proteins. We performed a large-scale transcriptomic analysis of WT SUM159 cells, identifying ∼7,700 transcripts (746 and 1,100 significantly increasing, 795 and 1,013 significantly decreasing in ONC201 and TR-57 treated cells, respectively). …”

Image6_Multi-omics analyses reveal ClpP activators disrupt essential mitochondrial pathways in triple-negative breast cancer.JPEG by Emily M. J. Fennell (6654536)

“…Notably, this included the downregulation of many mitochondrial processes and proteins, including mitochondrial translation and mitochondrial matrix proteins. We performed a large-scale transcriptomic analysis of WT SUM159 cells, identifying ∼7,700 transcripts (746 and 1,100 significantly increasing, 795 and 1,013 significantly decreasing in ONC201 and TR-57 treated cells, respectively). …”

Sections of testis from 6 month old male medaka stained with H&E. by Hilary D. Miller (29470)

“…F: Animal exposed to 10.0 µg/L EE2 for 14 days has a severe thickening of the interstitium, increased vacuolization, and an overall decrease in germinal epithelium. …”

Replacement of chicken skin with canola oil in chicken nuggets by Sandra Tiemi Seó (16453032)

“…There was a decrease in AI (T0%-raw vs. T100%-fried, 0.39 vs. 0.10) and IT (T0%-raw vs. …”

The <i>Citrobacter rodentium</i> type III secretion system effector EspO affects mucosal damage repair and antimicrobial responses by Cedric N. Berger (4544008)

“…<i>rodentium</i>. This overlapped with a decrease in STAT3 phosphorylation in IECs. Importantly, while the reduced CCH and abundance of antimicrobial proteins during Δ<i>espO</i> infection did not affect <i>C</i>. …”

Angiogenic response in ischemic limbs. by Masayuki Kubo (298705)

“…Quantitative analysis revealed that the blood flow (B) and microvessel density (D) in the ischemic hindlimb significantly decreased in the HSF1-KO mice compared to the WT mice, 21 days after the induction of ischemia (n = 5 or 6 animals/group).…”

HIF1α deletion affects <i>in vivo</i> virus growth expansion during acute infection. by Darlah M. López-Rodríguez (8098544)

“…Virus replication was significantly decreased on day 5 (<i>P<0</i>.<i>012</i>) or day 7 <i>(P<0</i>.…”

EFFECT OF WATER DEFICIT AND ABSCISIC ACID ON PHOTOSYNTHETIC AND ANTIOXIDANT METABOLISM IN SEEDLINGS OF Calophyllum brasiliense (CAMBESS.) by Lucas Coutinho Reis (6511265)

“…The decrease in stomatal conductance was accompanied by a decrease in photosynthetic and transpiration rates, but seedlings treated with 10 µM ABA presented a higher photosynthetic rate than the remaining treatments under water deficit. …”

Deletion of Gpr177 in embryonic epidermis leads to ablation of Wnt/β-catenin signaling in dermis. by Xiao-Jing Zhu (645748)

“…<p>(A) Quantitative RT-PCR shows a decrease in the expression of <i>Axin2, Dkk1, Fzd1, Lef1, TCF4</i> in limb skin of mutants at E16.5. **, P<0.01, compared to wild type controls. …”

Muscle fiber CSAs of the soleus and EDL muscles in the GH-administered SDRs treated with dexamethasone, BCAA or both. by Hikaru Nishida (757003)

“…Dex-treated group. D. Dex elicited a decrease in the CSAs of the EDL muscles in the GH-treated SDRs. …”