Acute effect of timolol on intracellular global Ca²⁺ changes, and the basal levels of intracellular both free Zn²⁺ and Ca²⁺ in ventricular hypergly... by Erkan Tuncay (438815)

“…(C) To record basal levels of both intracellular free Zn²⁺ and Ca²⁺ in resting cells in parallel, we used a ratiometric Fura-2 (4-µM Fura-2 AM) loaded cells and 50-µM N,N,N′,N′-tetrakis (2-pyridylmethyl) ethylenediamine (TPEN) (for more information about methods, see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0071014#pone.0071014-Tuncay1" target="_blank">[28]</a>). …”

Image_2_Combined Effect of CYP2C19 Genetic Polymorphisms and C-Reactive Protein on Voriconazole Exposure and Dosing in Immunocompromised Children.JPEG by Juan Chen (61123)

“…Covariates associated with voriconazole plasma concentrations and dose requirements were adjusted by using generalized linear mixed-effect models.</p>Results<p>A total of 682 voriconazole steady-state trough concentrations from 91 Chinese pediatric patients were included. …”

4-Octyl itaconate attenuates renal tubular injury in db/db mice by activating Nrf2 and promoting PGC-1α-mediated mitochondrial biogenesis by Muqing Shao (15238576)

“…<i>Irg1</i> knockout mice were generated. db/db mice were treated with 4-octyl itaconate (4-OI, 50 mg/kg), a derivative of itaconate, for 4 weeks. …”

Simulated dependence of [Ca²⁺] on electrical coupling following modulation of other K_ATP parameters. by Aleena M. Notary (625801)

“…<b>B).</b> As in A, for <i>g</i>_<i>coup</i> = 0pS. <b>C).…”

Data_Sheet_1_Macrophage Depletion in Elderly Mice Improves Response to Tumor Immunotherapy, Increases Anti-tumor T Cell Activity and Reduces Treatment-Induced Cachexia.PDF by Lelinh Duong (5932946)

“…The immune system plays a critical role in the effectiveness of many anti-cancer therapies in young hosts via tumor-specific T cells. …”

Identification of whole blood mRNA and microRNA biomarkers of tissue damage and immune function resulting from amphetamine exposure or heat stroke in adult male rats by Luísa Camacho (5508251)

“…Most transcripts specific for T-cells decreased 50–70% after AMPH exposure or EIH, with the noted exception of <i>Ccr5</i> and <i>Chst12</i>. …”

Five years comparation of efficacy and safety after ICL-V4c implantation for high and super high myopia correction by Qi Wan (271320)

“…Compared to baseline, we observed a significant increase in IOP at the 1-week follow-up, which decreased significantly at the one-month visit. …”

Image_1_Combined Effect of CYP2C19 Genetic Polymorphisms and C-Reactive Protein on Voriconazole Exposure and Dosing in Immunocompromised Children.JPEG by Juan Chen (61123)

“…Covariates associated with voriconazole plasma concentrations and dose requirements were adjusted by using generalized linear mixed-effect models.</p>Results<p>A total of 682 voriconazole steady-state trough concentrations from 91 Chinese pediatric patients were included. …”

Mobility Competitiveness and Security: Expatriate Perspectives from Qatar by Ewers, Michael Christopher

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Length-dependent activation in NF trabeculae (<i>n</i> = 9) vs. failing trabeculae with no hypothyroidism (FNH; <i>n</i> = 9) and failing trabeculae with hypothyroidism (FH; <i>n</... by Nancy S. Saad (2615341)

“…<b>(E)</b> RT50 decreased as muscles were shortened from L₁₀₀ to L₈₅ and the degree of shortening was much obvious in NF group. …”

Sound evoked cortical activity across vigilance states before and after NOE. by Linus Milinski (10532121)

“…Sounds were one octave narrow band noise (NBN) bursts centred at 1, 4, 8, and 16 kHz, at a stimulus level of 40, 50, 60, and 65 dB SPL, with a duration of 820 ms that included a silent gap of 38 ms. …”

DataSheet1_Mechanism of Tripterygium wilfordii Hook.F.- Trichosanthes kirilowii Maxim decoction in treatment of diabetic kidney disease based on network pharmacology and molecular... by Lingfei Lu (5400374)

“…Molecular docking results showed that kaempferol, triptolide, nobiletin, and schottenol had a strong binding ability to PTGS2 and RELA. Furthermore, the in vitro experiments confirmed that LTD effectively decreased the expression of PTGS2, NF-κB, JNK, and AKT in the HG-induced DKD model.…”

Mosquito-Disseminated Insecticide for Citywide Vector Control and Its Potential to Block Arbovirus Epidemics: Entomological Observations and Modeling Results from Amazonian Brazil by Fernando Abad-Franch (127663)

“…We tested mosquito-disseminated PPF in Manacapuru, a 60,000-inhabitant city (~650 ha) in Amazonian Brazil.…”

Table_1_Comprehensive Multi-Omics Identification of Interferon-γ Response Characteristics Reveals That RBCK1 Regulates the Immunosuppressive Microenvironment of Renal Cell Carcinom... by Wenhao Xu (2302681)

“…Besides, immunohistochemistry staining showed significantly elevated RBCK1 expression in tumors (n = 50) compared with kidney samples (n = 40) from a real-world cohort, Fudan University Shanghai Cancer Center (FUSCC, Shanghai). …”

Data_Sheet_1_Functional Exhaustion of Type I and II Interferons Production in Severe COVID-19 Patients.docx by Caroline Ruetsch (9691565)

“…In vitro treatment with type IFNα restored type IFNγ secretion in COVID-19 patients while the secretion of pro-inflammatory cytokines IL6 and IL1β remained stable or decreased, respectively. These results (a) demonstrate a functional exhaustion of both innate and adaptive immune response in severe forms of COVID-19; (b) identify IFNα and IFNγ as new potential biomarkers of severity; and (c) highlight the importance of targeting IFNs when considering COVID-19 treatment in order to re-establish a normal balance between inflammatory and Th1 effector cytokines.…”

Datasheet1_Short-term exposure to ultrafine and fine particulate matter with multipollutant modelling on heart rate variability among seniors and children from the CorPuScula (coro... by Pascale Haddad (678636)

“…</p>Methods<p>CorPuScula (Coronary, Pulmonary and Sanguis) is a longitudinal, repeated-measure panel study conducted in 2000–2002 in Munich, Germany including 52 seniors (58–94 years old) with 899 observations and 50 children (6–10 years old) with 925 observations. …”

Concomitant nevirapine impacts pharmacokinetic exposure to the antimalarial artemether-lumefantrine in African children by Liusheng Huang (610226)

“…Similarly, peak concentration was decreased by 50% (p = 0.07) for artemether and 36% (p = 0.01) for dihydroartemisinin. …”

Datasheet1_Short-term exposure to ultrafine and fine particulate matter with multipollutant modelling on heart rate variability among seniors and children from the CorPuScula (coro... by Pascale Haddad (678636)

“…</p>Methods<p>CorPuScula (Coronary, Pulmonary and Sanguis) is a longitudinal, repeated-measure panel study conducted in 2000–2002 in Munich, Germany including 52 seniors (58–94 years old) with 899 observations and 50 children (6–10 years old) with 925 observations. …”

Proxy-based paleoclimate series for the last 5000 years. by David Kaniewski (218243)

“…Interval of high (low) Cyperaceae pollen percentages are interpreted in terms of increased (decreased) Nile flow; (<b>g</b>) fluctuations of the δ¹⁸O speleothem scores from Soreq Cave, Israel, for the last 3600 years <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0071004#pone.0071004-BarMatthews1" target="_blank">[70]</a>. …”

Table 1_Multicenter epidemiology of Stenotrophomonas maltophilia bloodstream infections in Indian ICUs: building digital surveillance network.pdf by Parul Singh (191877)

“…Mortality was highest in secondary BSIs (60%), followed by CLABSIs (50.3%) and non-CLABSIs (36.4%). The median ICU stay for CLABSI patients was 21 days. …”