Hnf6 Tg animals exhibit abnormal islet morphogenesis. حسب Laura Wilding Crawford (41616)

"…Total insulin⁺ area decreases in transgenic animals (dark green) at postnatal stages, but does not appear to be altered during embryogenesis. e15.5, n = 4; e18.5, n = 4; P1, n = 2; 2 weeks, n = 3. …"

Effect of the surface charge of HN protein on its structural stability. حسب Yu Shang (49702)

"…The protein stability is shown as the temperature for a 50% decrease in Δ Ellipticity at 222 nm (T_m-CD). …"

Proteins from the TSC/mTOR pathway are regulated by p19. حسب Maria Camats (255397)

"…C) western blot analysis with anti-p-70S6K (Thr389) antibodies on proteins from HeLa cells transfected with pRK5, pRK5-p19, and pRK5-p19mut. A decrease of p-70S6K by 50% were quantified in lanes pRK5-p19 versus pRK5. …"

Differentially regulated genes reside in closed chromatin regions and undergo dynamic changes in chromatin signature during fate transitions. حسب Ao Liu (481251)

"…<b>(B)</b> Example of a shared bHLH target (SWEET5) that is nucleosome bound (MNase-seq [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002770#pbio.3002770.ref038" target="_blank">38</a>]; top track, deep blue), heavily H3K27me3-methylated in early stomatal lineage cells (H3K27me3 ChIP-seq in FAMA^LGK cells [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002770#pbio.3002770.ref037" target="_blank">37</a>]; second track, light blue) and shows a decrease in H3K27me3 in mature GCs (H3K27me3 ChIP-seq in GC [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002770#pbio.3002770.ref037" target="_blank">37</a>]; third track, green); the bottom 5 tracks show binding of the stomatal lineage bHLHs and the chromatin remodeler BRM from ChIP-seq experiments. …"

Turbocharging Matched Molecular Pair Analysis: Optimizing the Identification and Analysis of Pairs حسب Iva Lukac (593803)

Temporal Regulation of Myopia and Inflammation-Associated Pathways in the Interphotoreceptor Retinoid-Binding Protein Knockout Mouse Model حسب Shanu Markand (19730205)

"…</p> <p>The ddPCR data analysis indicated that numerous myopia and inflammation-associated genes were differentially regulated in IRBP KO retinas with distinct temporal variation (upregulated at P5, decreased at P40, and no change at P213 relative to WT). …"

Cell morphology drives consortial population dynamics and strain fixation. حسب James J. Winkle (7181861)

"…Destabilization of the columnar structure of the WT strain led to its eventual extinction in all simulations; grey curves: 20 individual simulations; solid orange curve: mean strain fraction trajectory; dashed curve: Fit of 1 − 0.5<i>e</i>^{−<i>α</i>(<i>t</i>−5)}. …"

Proteasome Inhibitors Block DNA Repair and Radiosensitize Non-Small Cell Lung Cancer حسب Kyle R. Cron (455028)

"…Proteasome inhibition resulted in an 80–90% decrease in homologous recombination (HR), a 50% decrease in expression of NF-κB-inducible HR genes <i>BRCA1</i> and <i>FANCD2</i>, and a reduction of BRCA1, FANCD2 and RAD51 ionizing radiation-induced foci. …"

Y-27632 treatment of P19 cells inhibits the differentiation of primitive endoderm. حسب Roman J. Krawetz (309735)

"…FACS analysis demonstrates a significant decrease in GATA-6 and Troma-1 positive cells with Y-27632 present (K). …"

Menthol and eugenol as natural anesthetics for early juveniles of curimba حسب Elias Fernandes de Medeiros Junior (4832202)

"…Increased concentrations led to a decrease in recuperation time. The concentrations between 50 to 70 mg of eugenol L−1 provided the lowest induction times; however, recovery time was not affected by eugenol concentrations. …"

Waterfall plot showing the quantitative changes in ER, PR, and Ki-67 expression. حسب Yuqin Ding (623253)

"…(A) ER discordance rate: 10.4% (50/482) of patients, including 36 (7.5%) patients with positive-to-negative conversion and 14 (2.9%) patients with negative-to-positive conversion; (B) PR discordance rate: 17.0% (82/482) of patients, including 57 (11.8%) patients with positive-to-negative conversion and 25 (5.2%) patients with negative-to-positive conversion; (C) Ki-67 discordance rates: 50.4% (243/448) of patients had decreased expression and 27.0% (130/448) of patients had increased expression.…"

Effects of endogenous prostanoids and selective agonists on the beating rate of neonatal rat cardiomyocytes. حسب Hakima Mechiche (308181)

"…“bradyarrhythmia” indicated a decrease of more than 50%; “tachyarrhythmia” indicated an increase of more than 50% with chaotic, asynchronous, activity of the myocytes <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0045273#pone.0045273-Li1" target="_blank">[13]</a>; <i>n</i> is the number of preparations on which brady- or tachy-arrhythmia was observed.…"

Diagram illustrating <i>Nrxn1</i> allelic series and examination of <i>Nrxn1</i> isoform specific expression. حسب Bing Xu (69508)

"…(B) <i>Nrxn1α</i> mRNAs containing the exon 9 sequence is decreased to about 50% in ΔExon9/+ mice and 100% in ΔExon9/ΔExon9 mice compared to +/+ WT controls (Exon9 labelled as ΔEx9). …"

pQTL analysis of IFN-α and IFN-γ receptor levels and responses. حسب Christian Lundtoft (4068679)

"…Blue indicates a decrease in minor allele carriers, while red indicates an increase in minor allele carriers. …"

Genetic ablation of <i>C1ql1</i>-expressing OPCs prevents myelination in the forebrain without affecting axogenesis. حسب Shayan Moghimyfiroozabad (19066182)

"…Data are represented as mean ± SEM. <i>C1ql1</i>^<i>wt</i><i>; Sox10</i>^<i>DTA</i>: <i>n</i> = 5 animals. …"

Table_6_Biological, Behavioral and Physiological Consequences of Drug-Induced Pregnancy Termination at First-Trimester Human Equivalent in an Animal Model.DOCX حسب Christina Camilleri (6751091)

"…Following drug/vehicle administration, only the pregnancy termination group (pregnant, drug) displayed a significant decrease in body weight, food intake, locomotor activity-related behaviors and home-cage activity relative to the control group (non-pregnant, vehicle). …"

Table_10_Biological, Behavioral and Physiological Consequences of Drug-Induced Pregnancy Termination at First-Trimester Human Equivalent in an Animal Model.DOCX حسب Christina Camilleri (6751091)

"…Following drug/vehicle administration, only the pregnancy termination group (pregnant, drug) displayed a significant decrease in body weight, food intake, locomotor activity-related behaviors and home-cage activity relative to the control group (non-pregnant, vehicle). …"

Table_12_Biological, Behavioral and Physiological Consequences of Drug-Induced Pregnancy Termination at First-Trimester Human Equivalent in an Animal Model.DOCX حسب Christina Camilleri (6751091)

"…Following drug/vehicle administration, only the pregnancy termination group (pregnant, drug) displayed a significant decrease in body weight, food intake, locomotor activity-related behaviors and home-cage activity relative to the control group (non-pregnant, vehicle). …"

Table_9_Biological, Behavioral and Physiological Consequences of Drug-Induced Pregnancy Termination at First-Trimester Human Equivalent in an Animal Model.DOCX حسب Christina Camilleri (6751091)

"…Following drug/vehicle administration, only the pregnancy termination group (pregnant, drug) displayed a significant decrease in body weight, food intake, locomotor activity-related behaviors and home-cage activity relative to the control group (non-pregnant, vehicle). …"

Table_7_Biological, Behavioral and Physiological Consequences of Drug-Induced Pregnancy Termination at First-Trimester Human Equivalent in an Animal Model.DOCX حسب Christina Camilleri (6751091)

"…Following drug/vehicle administration, only the pregnancy termination group (pregnant, drug) displayed a significant decrease in body weight, food intake, locomotor activity-related behaviors and home-cage activity relative to the control group (non-pregnant, vehicle). …"