TLR2 KO Mice Demonstrate Reduced Distant Organ Injury by W. Joost Wiersinga (33895)

“…<p>Mice were intranasally inoculated with 5 × 10² CFU of B. pseudomallei. After 72 h, representative spleen histology of WT (A) and TLR2 KO (B) mice demonstrated decreased inflammation and less thrombus formation in the TLR2 KO spleens. …”

miR-135b negatively regulates SMAD5 expression. by Song Xu (187853)

“…<p>(A) Transfection with miR-135b inhibitor or mimic leads to a decrease or an increase of miR-135b expression in hMSCs. …”

<i>In vitro</i> and <i>in vivo</i> properties of aminotriazines used in this study. by David J. Matson (625974)

“…Analgesic efficacy was determined by a statistically significant (p < 0.05) decrease in formalin-induced flinching for which the same dose did not produce a reduction in movement in the open field assay that obviated the formalin result. …”

Climate Change and the Distribution of Neotropical Red-Bellied Toads (<i>Melanophryniscus</i>, Anura, Amphibia): How to Prioritize Species and Populations? by Caroline Zank (586679)

“…We used the MaxEnt algorithm to project current and future suitable climatic areas (a consensus of IPCC scenarios A2a and B2a for 2020 and 2080) for each species. 40% of the species may lose over 50% of their potential distribution area by 2080, whereas 28% of species may lose less than 10%. …”

BRCA1 suppressor strains are sensitive to DNA damaging agents. by Craig B. Bennett (38005)

“…<i>SPT5</i> is an essential gene, however the relative survival of two strains (<i>yml009W-bΔ</i> and <i>yml009c-aΔ</i>) containing non-lethal C terminal truncations of <i>SPT5</i> was enhanced when compared to WT following BRCA1 expression. …”

<i>S</i>. <i>mediterranea</i> cathepsin protease mRNA is reduced after starvation while dsRNA treatment with SmedCB is specific to cathepsin B. by Louise S. Goupil (2922159)

“…Cathepsin L mRNA was reduced, on average, 20% with the exception of day 14, which had a 50% reduction. <b>(B)</b> Worms injected with ~100ng of SmedCB dsRNA for three consecutive days, followed by amputation (day 0) and three weeks of starvation, showed a marked reduction of SmedCB mRNA when analyzed via RTPCR using GAPDH mRNA levels as a baseline control. …”

Thrombin specific impairment in soluble fibrinogen binding and aggregation in PP1cγ^−/− platelets. by Francisca C. Gushiken (368549)

“…Studies are indicated as ±SEM of 5–6 experiments. The decreased aggregation in 0.02 U/ml thrombin stimulated PP1cγ^−/− platelets compared to WT platelets was significant at *p = 0.04.…”

Optimization of harvest preferences. by Alex Potapov (811655)

Structural plasticity of the lamina is controlled by the parallel action of a circadian clock and a phototransduction-dependent mechanism. by Martin Barth (367106)

“…<p><b>a</b>, Lamina volumes of adult wild-type CS (WT CS) flies kept under LL, LD, or DD conditions during adult life. …”

Gcn4 dependent outputs can sustain high translation capacity during growth. by Rajalakshmi Srinivasan (395110)

“…Barplots, comparing the relative amount of proteins translated (in a methionine-dependent manner), for the genes shown in Fig 5B. These selected genes were cloned in frame with luciferase in an inducible system, to create a translation-reporter (<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1009252#pgen.1009252.s014" target="_blank">S14 Fig</a>), and translation of these were induced in WT or <i>Δgcn4</i> cells in methionine supplemented medium (MM+Met). …”

Hyperacetylation induced by chemical HDAC inhibition stresses the replication fork of FANCA deficient cells. by Benilde García-de Teresa (17838878)

“…<b>(D)</b> Representative immunoblots after capture of the replication fork of SAHA treated wild type and FA cells. Lanes 1 to 5 total protein of INPUT samples: lane 1 no click control, iWT cells in lanes 2 (pulse) and 3 (SAHA and pulse), FA-A cells in lanes 4 (pulse) and 5 (SAHA and pulse). …”

PINK1 expression alters mitochondrial function and cellular viability. by Anna Sandebring (263540)

“…A control lentivirus expressing LacZ is shown in lane 1, lanes 2–4 are cell lines expressing wild-type (WT), G309D or kinase dead (KD) PINK1. The PINK1 in these cells is V5-tagged at the C-terminus, the precursor (arrow) and mature (closed arrowhead) forms of PINK1 are visible. …”

Detection of glycan-dependent HIV-1 neutralizing antibodies in sera from LTNPs and typical progressors. by Nuria González (4532422)

“…Percent serum neutralizing activity sensitive to the indicated residue replacement was calculated using the equation [1 − (ID50 mutant/ID50 wild type)] x 100. A sample is considered positive if there is a decrease in ID50 greater than or equal to 50% for the mutant relative to the wild-type virus. …”

<i>Nacα</i> and <i>Hox</i> genes interact to redirect differentiation of Multipotent Cardiac Progenitors (MCPs). by Analyne M. Schroeder (13961877)

Table 1_Biochar of hazelnut shell mitigates cadmium toxicity in forage soybean.xlsx by Sedat Severoğlu (22489270)

“…Compared to the B0Cd0 treatment, the B0Cd1, B0Cd2, and B0Cd3 treatments resulted in 45, 62 and 67% decrease in shoot fresh weight (SFW), 37, 46 and 50% decrease in shoot dry weight (SDW), 31, 45 and 56% in root fresh weight (RFW), 34, 50 and 59% in root dry weight (RDW), and 13, 29 and 40% de-crease in LA. …”

Kinetics of differential gene expression after rapid degradation of endogenous OGT in MEFs. by Sara Formichetti (20536052)

“…Differentially expressed genes with p-value < 10⁻⁵ and absolute log₂FC > 0.3 (i.e. 1.2-fold increase or decrease in expression) are labeled in red and their number is indicated. …”

Data_Sheet_1_Mitofusin 2 Is Essential for IP3-Mediated SR/Mitochondria Metabolic Feedback in Ventricular Myocytes.PDF by Lea K. Seidlmayer (6997946)

“…In contrast to ET-1, ISO induced a decrease in ATP levels in WT myocytes. Mfn2 KO abolished ATP generation upon ET-1 stimulation but increased ATP levels upon ISO application with highest levels observed in PNM regions.…”

Data_Sheet_1_Mitofusin 2 Is Essential for IP3-Mediated SR/Mitochondria Metabolic Feedback in Ventricular Myocytes.PDF by Lea K. Seidlmayer (6997946)

“…In contrast to ET-1, ISO induced a decrease in ATP levels in WT myocytes. Mfn2 KO abolished ATP generation upon ET-1 stimulation but increased ATP levels upon ISO application with highest levels observed in PNM regions.…”

The sequence between nt. 626/640 mediates both TPA-dependent activation and the negative regulation by T3/TR. by Hiroko Misawa (335240)

“…The stimulatory effect by TPA is decreased in MA. In the presence or absence of TPA (100 ng/ml), pBL-FFL-CAT5 (WT) or its mutants (MA-D) were transfected into CV1 cells. …”

Density-mediated metabolic rate in <i>Daphnia magna</i> interacting with temperature by Huanan Gao (12301705)

“…At both temperatures, metabolic rates of <i>D. magna</i> in the 2 crowded treatments were significantly lower than those in a single treatment, and as temperature decreased the rate of metabolic decrease slowed. …”