Proposed model of interrelationships between HIV, immune activation and the Th17/Treg ratio. by Mathieu F. Chevalier (424305)

FSM^R GAPDH variants support robust catalytic efficiency but exhibit altered cooperativity. by Andrew J. Jezewski (8934521)

“…A statistically significant decrease in catalytic efficiency is measured for the GAPDH^V238A variant compared to WT. …”

Activity of the small molecule PLK1, 2, and 3 inhibitor BI 2536 in preclinical models of MM in the absence of the bone microenvironment. by Douglas W. McMillin (348456)

“…<p>(A) BI 2536 (0–80 nM; 72 hrs) was tested against a panel of MM cell lines by MTT assay, the majority having IC50 values <40 nM. …”

Neuronal stress remodels fat metabolism by suppressing TGF-β/BMP signaling. by Laetitia Chauve (8600553)

“…<b>(D, E)</b> Genetic epistasis shows that <i>hsf-1</i>^<i>neuro</i> and <i>dbl-1</i> work in a linear pathway to decrease <i>fat-7</i> expression. Quantification of <i>fat-7p</i>::<i>GFP</i> fluorescence in age-matched L4.9 animals from the following backgrounds: WT (HA1842), <i>hsf-1</i>^<i>neuro</i> <i>#2</i> (MOC151), and <i>dbl-1(nk3)</i> (MOC279) <i>hsf-1</i>^<i>neuro</i> <i>#2;dbl-1(nk3)</i> (MOC347). …”

DSS-induced colitis mouse model. by William C. Reisdorf (6616148)

“…Experimental groups were: Sham = vehicle control (no DSS or other treatment, n = 6), DSS = DSS-only (n = 12), CsA = 10 mg/kg i.p. treatment (n = 6), EPHX2i = GSK1910364A 50 mg/kg orally, twice daily (n = 6). …”

The effect of GIRK4 and RGS6 ablation on APD₈₀. by Kanchan Kulkarni (5029712)

“…(C-E) The effect of CCh on APD₈₀ at decreasing BCL in WT, <i>Girk4</i>^<i>-/-</i>, and <i>Rgs6</i>^<i>-/-</i> hearts. (‘*’ denotes statistical significance of p < 0.05 between baseline and 300nM CCh; ‘&’ denotes statistical significance of p < 0.05 between baseline and 3uM CCh). n = 8, 5, 8 for WT, <i>Rgs6</i>^<i>-/-</i>, and <i>Girk4</i>^<i>-/-</i>_, respectively. …”

The mRNA expression of ST6Gal1 and FUT9 is modulated by L1. by Ya-li Li (268778)

“…The expression of fucosyltransferase 9 (FUT9) was elevated in the “neurons-L1Ab” versus “neurons” group (1.414-fold) and decreased in the L1ko neurons versus L1wt neurons group (0.218-fold), and β-galactoside-α2,6-sialyltransferase (ST6Gal1) expression was elevated in the “neurons-L1Ab” compared to the “neurons” group (1.249-fold) and decreased in the L1ko neurons versus L1wt neurons group (0.574-fold). …”

Effect of C-terminal E domains and prM protein on the recognition of E protein by different mouse anti-E mAbs. by Wen-Yang Tsai (108058)

“…<p>(A) Binding specificity of five mouse anti-E mAbs including GR (4G2 and DEN2-12), CR (DEN3-3), and DENV4 TS (1H10-6-7 and 1H10-5-7) mAbs. …”

Intense reelin IR neurons synthesize reelin whereas punctate reelin IR neurons are characterized by the presence of receptor-bound reelin. by Cecilia Gonzalez Campo (264260)

“…GST-RAP was used at 25, 40 and 50 µg/ml. A significant decrease of punctate reelin IR was observed with 40 and 50 µg/ml of GST-RAP (4.5±1.5% and 3.1±0.7%; n = 3 and 3) whereas no effect was detected with a concentration of 25 µg/ml compared to untreated (22.2±1.4% and 21.3±2.2%; n = 3 and 3; F_(3,8) = 45.7, ***P<0.001). …”

Clinical and virological profiles of D9 vaccine trial group. by Jodi K. Craigo (421284)

“…<p>(<b>A</b>) Eight EIAV-naïve ponies were vaccinated with 3×10³ TCID₅₀ D9 I.M. …”

Effect of the lytic enzyme PeiR on M1 growth <i>in vitro</i>. by Sinead C. Leahy (244590)

Effect of anisotropy. by Diarmuid J. Cahalane (233294)

The effect of inhibition on metabolically efficient information transfer. by Tomas Barta (8067509)

Effect of aerobic exercise on intramyocellular (IMCL) and intrahepatocellular lipids (IHCL). by Andrea Egger (107540)

“…<p><b><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0070865#pone-0070865-g003" target="_blank"><b>Figure 3a</b></a></b> Individual IMCL and IHCL measurements before (pre) and after (post) a 2h-aerobic exercise at 50% VO_2max of each subject. …”

I-R-Polar-Negative-0902 by Sheng-Yuan Ho (16909464)

“…As the lockmass, we utilized leucine-enkephalin (m/z = 556.2771) at a concentration of 1 ng/L and a flow rate of 5 L/min. …”

Analytical vs numerical evaluation of oscillatory solutions in the Gaussian-drift approximation. by Natalie Schieferstein (17996519)

“…Including the reset does not affect <i>μ</i>_max but leads to a decrease in <i>μ</i>_min (Eqs (<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1011886#pcbi.1011886.e181" target="_blank">50</a>) vs (<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1011886#pcbi.1011886.e172" target="_blank">43</a>)) and thus a decrease in network frequency. …”

Overexpression of <i>hsf-1</i>^<i>neuro</i> in neurons activates a fat remodeling transcriptional program that resembles one activated by worms acclimated at 25°C. by Laetitia Chauve (8600553)

“…<b>(K)</b> <i>hsf-1</i>^<i>neuro</i> causes a decrease in OA. GC–MS analysis was performed to quantify total FA levels (in μg per ml) in <i>hsf-1</i>^<i>neuro</i> <i>#2</i> (AGD1289) compared to WT controls. …”

Intracellular perfusion of astrocyte with inhibitors of vesicular transport of ATP selectively affects slower purinergic EPSCs. by Ulyana Lalo (506296)

“…Note the decrease in the amplitude of slow sEPSCs recorded in the presence of AP3A and lack of changes in the fast sEPSC. …”

Serum dilution optimization. by Brian J. Pak (610752)

“…Dilutions of 1∶10 and 1∶20 generated the highest antibody signal with no differences between the two dilutions (<i>p</i> = 0.17), while a significant decrease in signal intensity was observed between 1∶20 and 1∶50 dilutions (<i>p</i><0.001). …”

Arrhenius and Eyring analysis of McLOV proteins. by Kaley K. El-Arab (733285)

“…In contrast 337-TF, has markedly increased enthalpies of activation (71 kJ/mole vs. ~50 KJ/mole) with a decrease in the entropic penalty (-44 J/mole*K vs. ~ -100 J/mole*K).…”