Mutational analysis to define the P1 and P2 fragment trypsin cleavage sites. by David A. Gross (143464)

“…<p><b>A</b>, Cells were set up as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0010796#pone-0010796-g005" target="_blank">Fig. 5</a> by expressing either K240A, K256A, R257A (all constructs are V5 tagged) and compared to wild-type FIT2-V5 (WT) in limited trypsin digestion time course assays as indicated. …”

Inflammasome elements are important for TIN progression, and inhibition of the xanthine oxidoreductase system attenuates the development of this disease. by Matheus Correa-Costa (119464)

“…WT group). In addition, allopurinol-treated animals exhibited renoprotection, as demonstrated by decreased serum creatinine levels (G) (ANOVA test - p<0.0001, with Tukey post test *p<0.01 vs. adenine group), fibrosis deposition (H) (ANOVA test - p<0.0001, with Tukey post test *p<0.001 vs. adenine group), tubular dilation (I) (ANOVA test - p = 0.0001, with Tukey post test *p<0.01 vs. adenine group), tissue uric acid levels (J) (ANOVA test p = 0.0159, with Tukey post test *p<0.05 vs. adenine group), presence of ox-LDL (K) (ANOVA test - p = 0.0211, with Tukey post test, *p<0.05 vs. adenine group) and (L) GSH/GSSG ratio (ANOVA test - p = 0.0002, with Tukey post test *p<0.001 vs. control and allopurinol groups). n = 5 animals/group.…”

Long-term acceptance of MHC mismatched cardiac allograft in Nur77Tg recipients. by Ran Tao (81449)

“…Recipient anti-donor responder frequencies were determined by IFN-γ spot-forming cells (SFC)/2×10⁵ recipient T cells (mean±SD); *p<0.01 and ** p<0.005 for WT vs. …”

Simulations suggest spatial confinement causes the late-stage rearrangement of sarcolytes. by Daiki Wakita (8080223)

“…<p>Parameter changes to slow down the muscle units were performed from 30 to 50 hAPF (steps 129,600–273,600). (a–e) Snapshots of the left halves of simulation fields at 40 and 50 hAPF: (a) spatial confinement, (b) decrease in the self-propelling force strength of hemocytes, (c) increase in the friction coefficient of all the particles, (d) increase in the adhesion strength between a hemocyte and a fat body cell, (e) increase in the adhesion strength between hemocytes. …”

Expression of two <i>tenascin</i> genes is affected by temperature. by Che-Yi Lin (218292)

“…(L-O) Decreased <i>tnw</i> expression in all tissues, including scattered epidermal cells in the head (black arrows in M and O) was observed in both 22-ss WT and <i>s1pr2^as10</i> mutants raised at 22.5°C. …”

Doxycycline modulates VEGF-A expression: Failure of doxycycline-inducible lentivirus shRNA vector to knockdown VEGF-A expression in transgenic mice - Fig 3 by Mari Merentie (4781907)

“…In WT mice a decreasing effect on plasma VEGF-A was seen (a). …”

Micromolar ZnCl₂ reduces the amplitude of the time-dependent current. by Monica Bregante (3391766)

“…<p>A) The decrease of a typical inward time-dependent current induced by the addition of 100 μM ZnCl₂ to the bath solution. …”

Unpaired adenosines exclusive to Bacteria 16S rRNAs. by Chaitanya Muralidhara (223748)

“…<p>The 100 positions identified in the A nucleotide segment of the second 16S eigenorganism with the largest decrease in relative nucleotide frequency include all 50 positions (red) in the alignment with unpaired A nucleotides exclusively conserved in the Bacteria. …”

DataSheet_2_BRAFV600E Mutation-Responsive miRNA-222-3p Promotes Metastasis of Papillary Thyroid Cancer Cells via Snail-Induced EMT.pdf by Yuan Gao (159945)

“…Clinical data showed the significant up-regulation of miR-222-3p in PTC; however, the role of miR-222-3p and possible relationship with BRAF mutation remained unclear. Here, we identified significant up-regulation of miR-222-3p in PTC tissues harboring BRAF^V600E mutation compared with BRAF wild type (BRAF^WT) from collected PTC clinical samples. …”

DataSheet_6_BRAFV600E Mutation-Responsive miRNA-222-3p Promotes Metastasis of Papillary Thyroid Cancer Cells via Snail-Induced EMT.zip by Yuan Gao (159945)

“…Clinical data showed the significant up-regulation of miR-222-3p in PTC; however, the role of miR-222-3p and possible relationship with BRAF mutation remained unclear. Here, we identified significant up-regulation of miR-222-3p in PTC tissues harboring BRAF^V600E mutation compared with BRAF wild type (BRAF^WT) from collected PTC clinical samples. …”

Image_2_BRAFV600E Mutation-Responsive miRNA-222-3p Promotes Metastasis of Papillary Thyroid Cancer Cells via Snail-Induced EMT.jpeg by Yuan Gao (159945)

“…Clinical data showed the significant up-regulation of miR-222-3p in PTC; however, the role of miR-222-3p and possible relationship with BRAF mutation remained unclear. Here, we identified significant up-regulation of miR-222-3p in PTC tissues harboring BRAF^V600E mutation compared with BRAF wild type (BRAF^WT) from collected PTC clinical samples. …”

Image_3_BRAFV600E Mutation-Responsive miRNA-222-3p Promotes Metastasis of Papillary Thyroid Cancer Cells via Snail-Induced EMT.jpeg by Yuan Gao (159945)

“…Clinical data showed the significant up-regulation of miR-222-3p in PTC; however, the role of miR-222-3p and possible relationship with BRAF mutation remained unclear. Here, we identified significant up-regulation of miR-222-3p in PTC tissues harboring BRAF^V600E mutation compared with BRAF wild type (BRAF^WT) from collected PTC clinical samples. …”

DataSheet_4_BRAFV600E Mutation-Responsive miRNA-222-3p Promotes Metastasis of Papillary Thyroid Cancer Cells via Snail-Induced EMT.zip by Yuan Gao (159945)

“…Clinical data showed the significant up-regulation of miR-222-3p in PTC; however, the role of miR-222-3p and possible relationship with BRAF mutation remained unclear. Here, we identified significant up-regulation of miR-222-3p in PTC tissues harboring BRAF^V600E mutation compared with BRAF wild type (BRAF^WT) from collected PTC clinical samples. …”

DataSheet_1_BRAFV600E Mutation-Responsive miRNA-222-3p Promotes Metastasis of Papillary Thyroid Cancer Cells via Snail-Induced EMT.pdf by Yuan Gao (159945)

“…Clinical data showed the significant up-regulation of miR-222-3p in PTC; however, the role of miR-222-3p and possible relationship with BRAF mutation remained unclear. Here, we identified significant up-regulation of miR-222-3p in PTC tissues harboring BRAF^V600E mutation compared with BRAF wild type (BRAF^WT) from collected PTC clinical samples. …”

Image_1_BRAFV600E Mutation-Responsive miRNA-222-3p Promotes Metastasis of Papillary Thyroid Cancer Cells via Snail-Induced EMT.jpeg by Yuan Gao (159945)

“…Clinical data showed the significant up-regulation of miR-222-3p in PTC; however, the role of miR-222-3p and possible relationship with BRAF mutation remained unclear. Here, we identified significant up-regulation of miR-222-3p in PTC tissues harboring BRAF^V600E mutation compared with BRAF wild type (BRAF^WT) from collected PTC clinical samples. …”

DataSheet_3_BRAFV600E Mutation-Responsive miRNA-222-3p Promotes Metastasis of Papillary Thyroid Cancer Cells via Snail-Induced EMT.zip by Yuan Gao (159945)

“…Clinical data showed the significant up-regulation of miR-222-3p in PTC; however, the role of miR-222-3p and possible relationship with BRAF mutation remained unclear. Here, we identified significant up-regulation of miR-222-3p in PTC tissues harboring BRAF^V600E mutation compared with BRAF wild type (BRAF^WT) from collected PTC clinical samples. …”

Thymocytes in γδ T cell-deficient mice. by Swati Popat Phalke (6876818)

“…C) Comparison of CD8+ or CD4+ single-positive CD122+CD44+ TCR-β+ thymocytes in C57BL/6 (wt), B6.TCR-Vγ4/6KO and B6.TCR-Vγ4/6KO/IL-4KO mice. …”

Table 1_Photosynthetic characteristics of Paris polyphylla var. chinensis in response to different light intensities and soil water contents.xlsx by Yaling Zhang (1687540)

“…A comparison of Fv/Fm during the midday period showed that the optimum shade intensity is between 50% and 70%. …”

Cross-sections representing the model configurations. by Ondřej Lisický (9436801)

“…<p>Different WT of 0.5 mm (A), 0.25 mm (B) and 0 mm (C). The adventitia (dark blue) is always represented with 2 elements, as well as the media (light green). …”

Presentation1_Pulmonary nitric oxide in astronauts before and during long-term spaceflight.pdf by Lars L. Karlsson (17875562)

“…</p><p>Results: The levels of PENO at 50 mL/s (PENO50) were not stable during the preflight and inflight periods respectively but decreased with time (p = 0.0284) at a rate of 0.55 (0.24) [mean (SD)] mPa per 180 days throughout the observation period, so that there was a significant difference (p < 0.01, N = 10) between gravity conditions. …”