NNKTT120, an anti-iNKT cell monoclonal antibody, produces rapid and sustained iNKT cell depletion in adults with sickle cell disease by Joshua J. Field (176969)

“…In those subjects who received the two highest doses of NKTT120 (0.3, 1 mg/kg), iNKT cells were not detectable in the peripheral blood for a range of 2 to 5 months. There were no serious adverse events in the study deemed to be related to NKTT120. …”

Post-treatment controllers differ from HIV controllers in terms of HLA class I profile, frequency and quality of the CD8+ T cell response and activation levels of CD8+ T cells. by Asier Sáez-Cirión (3141075)

“…<p><b>A.</b> The frequencies of the protective alleles HLA-B*27 and B*57 and the risk alleles HLA-B*07 and B*35 in the general French population (n = 6094 alleles <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1003211#ppat.1003211-Alizadeh1" target="_blank">[20]</a>, <a href="http://www.allelefrequencies.net" target="_blank">www.allelefrequencies.net</a>), HICs (n = 148 alleles) and PTCs (n = 28 alleles). …”

The simulated effect of intracellular free magnesium ion concentration ([Mg²⁺]_i) on junctional conductance and the spread of excitation through electrical syn... by Mindaugas Snipas (3909556)

“…At [Mg²⁺]_i = 1.2 mM, junctional conductance is decreased ~2.5 fold. Such synaptic strength could only invoke an electrotonic response in the postsynaptic cell.…”

Measurement of ARF6-CFP and ARF1-CFP Activation at Phagosomes by Peter Beemiller (57945)

“…</p> <p>(C) The peak in ARF1-CFP activation was slightly delayed relative to ARF6-CFP, and ARF1-GTP was not restricted to a subregion of the phagosome. ARF1-GTP levels began to decrease as the closure phase began. …”

Data_Sheet_1_Observations supporting hypothetical commensalism and competition between two Campylobacter jejuni strains colonizing the broiler chicken gut.PDF by Sophie Chagneau (4337569)

“…In addition, a transcript level decrease of JAM2, CLDN5 and CLDN10 at 7 dpi and a transcript level increase of ZO1, JAM2, OCLN, CLDN10 were observed at 21 dpi for groups of birds having livers contaminated by C. jejuni. …”

Short-pulse photostimulation of VGluT2 GRN neurons in the freely walking mouse. by Maxime Lemieux (6630917)

“…(C) Averaged rectified EMG response of the iTA for each of the 5 periods of the step cycle. Upward arrows indicate a motor increase, and downward arrows indicate a motor decrease. …”

Crucial Role of Elovl6 in Chondrocyte Growth and Differentiation during Growth Plate Development in Mice by Manami Kikuchi (3145602)

“…These results were presumably due to a modest decrease in chondrocyte proliferation and accelerated differentiation of cells of the chondrocyte lineage. …”

Table1_Effect of 32-Weeks High-Intensity Interval Training and Resistance Training on Delaying Sarcopenia: Focus on Endogenous Apoptosis.XLSX by Hao Su (566065)

“…Both the HIIT and RT rats showed a decrease in the apoptosis of skeletal muscle cells after 32 weeks of intervention. …”

Data_Sheet_1_Inferring Whole-Organism Metabolic Rate From Red Blood Cells in Birds.pdf by Kasja Malkoc (11143776)

“…We predicted cMR to decrease as individuals transitioned from an active to a resting state. …”

Data_Sheet_2_Differential Effects of Ethical Education, Physical Hatha Yoga, and Mantra Meditation on Well-Being and Stress in Healthy Participants—An Experimental Single-Case Stud... by Karin Matko (11236839)

“…Conversely, participants in the MA condition showed no change (Tau-U = 0.07). There was a tendency for the combined treatments to decrease stress. …”

Image_1_The persistence of stress-induced physical inactivity in rats: an investigation of central monoamine neurotransmitters and skeletal muscle oxidative stress.jpeg by Trevor J. Buhr (10191398)

“…</p>Results<p>For experiment 1, stress exposure caused a shock number-dependent two to fourfold decrease in wheel running distance across the entire duration of the study. …”

Image_1_Comparative Metabolite and Gene Expression Analyses in Combination With Gene Characterization Revealed the Patterns of Flavonoid Accumulation During Cistus creticus subsp.... by Neda Aničić (10473857)

“…Finally, functional characterization of a Cistus flavonoid hydroxylase (F3′5′H) was performed for the first time.…”

Injection of ds<i>TcCPR4</i> prevents severe elytral morphological defects produced by RNAi for <i>TcCPR27</i>. by Mi Young Noh (360269)

“…<p>dsRNAs for <i>TcCPR4</i>, <i>TcCPR27</i>, <i>TcCPR4/27</i> and <i>TcVer</i> (100 ng per insect) were injected into late instar larvae (n = 40). (A) The expression of <i>TcCPR4</i> was analyzed by real-time PCR. cDNAs were prepared from total RNA isolated from 5 d-old pupae (n = 3). …”

Data_Sheet_1_Increasing Tau 4R Tau Levels Exacerbates Hippocampal Tau Hyperphosphorylation in the hTau Model of Tauopathy but Also Tau Dephosphorylation Following Acute Systemic In... by Matthew R. Barron (8533815)

“…Three-month-old male wild-type (Wt), mTau^+/−, mTau^−/−, hTau/mTau^+/−, and hTau/mTau^−/− mice were administered 100, 250, or 330 μg/kg of LPS or its vehicle phosphate buffer saline (PBS) [intravenously (i.v.), n = 8–9/group]. …”

Data_Sheet_1_Mortality rates from asbestos-related diseases in Italy during the first year of the COVID-19 pandemic.ZIP by Lucia Fazzo (14685007)

“…Background and aim<p>Patients with interstitial lung diseases, including asbestosis, showed high susceptibility to the SARS-CoV-2 virus and a high risk of severe COVID-19 symptoms. …”

Data_Sheet_1_Supplemental Fiber Affects Body Temperature and Fecal Metabolites but Not Respiratory Rate or Body Composition in Mid-Distance Training Sled Dogs.pdf by Emma Thornton (327620)

“…Diet had no effect on RR or body composition (P > 0.10), but exercise resulted in an overall 7% increase in lean and 3.5% decrease in fat mass (P < 0.05). These data suggest that increasing dietary soluble fiber may positively influence BT and gut health; however, it has no effect on RR or body composition. …”

Supplementary Material for: Clinical outcomes of persistent severe acute kidney injury among patients with KDIGO stage 2 or 3 AKI by Koyner J.L. (7505459)

“…For outcomes during 30-days post-discharge, aORs for PS-AKI vs. NPS-AKI were 1.07 (1.02-1.11) for readmissions, 1.33 (1.18-1.49) for in-hospital mortality, 15.66 (13.87-17.67) for dialysis, and 6.80 (5.84-7.93) for new dialysis. …”

Cardiac hypertrophy and fibrosis in aged α<i>MHC-Cre/Foxm1^fl/fl</i> mice. by Craig Bolte (299486)

Dynamic analysis of EC movements within Tg(<i>tie1</i>:H2B-eYFP) embryos. by Yuki Sato (243074)

“…A representative time lapse video (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0012674#pone.0012674.s004" target="_blank">Video S4</a>) was processed as follows: cropped time frames (5 through 67) corresponding to HH stages 9 to 11 and restricted region of interest to trunk level (posterior to somite 7, frame size is 500 mm ×1300 mm), and reduced noise using a median filter (3×3×3). …”

Age associated arrhythmicity is dependent on <i>ena</i> function. by Carolina Rezával (270700)

“…(C) Representative actograms of young (3d) and aged (21d) flies carrying one or two copies of <i>ena^rev</i>, along with the transheterozygotes <i>ena^rev</i>/<i>ena^GC5</i>. Both homozygous <i>ena^rev</i> and <i>ena^rev</i>/<i>ena^GC5</i> exhibit a decline on rhythm strength. …”