Selective TASK‑1 Inhibitor with a Defined Structure–Activity Relationship Reduces Cancer Cell Proliferation and Viability by Bárbara Arévalo (4053358)

“…Mutation of seven residues to A (I118A, L122A, F125A, Q126A, L232A, I235A, and L239A) markedly decreased the F3-induced inhibition of TASK-1 channels, consistent with the molecular modeling predictions. …”

Selective TASK‑1 Inhibitor with a Defined Structure–Activity Relationship Reduces Cancer Cell Proliferation and Viability by Bárbara Arévalo (4053358)

“…Mutation of seven residues to A (I118A, L122A, F125A, Q126A, L232A, I235A, and L239A) markedly decreased the F3-induced inhibition of TASK-1 channels, consistent with the molecular modeling predictions. …”

The corticospinal pathway is more susceptible to iterative stimulation and have lower conduction velocity in <i>taiep</i> rats. by Jose R. Eguibar (8563227)

“…<p><b>A)</b> Motor-evoked potentials (MEPs) induced by iterative electrical stimulation on the cerebral cortex showed a decrease in their amplitudes when increasing the stimulation rate from 5 to 30 Hz in <i>taiep</i> (blue squares), but not in WT rats (empty circles). …”

LPS administration demonstrated a significant decrease in the protein expression of both claudin-1 and occludin in BF fed mice as compared to control mice. by Valentina Di Caro (510473)

Leptin deficit hypoxia exposed-MSCs failed to limit cardiac fibroblast activation, through TGF-β/Smad2 and MRTF-A. by Panpan Chen (307628)

A-C. Inhibitors of cell death (zVAD-fmk and Nec-1) do not rescue the BMP2-induced decrease in cell numbers. by Charlotte Lagler (4017212)

Experimental scheme to compare molecular and parasitological parameters in mouse <i>EBi3</i>^<i>-/-</i> and WT infected with <i>S</i>. <i>mansoni</i> and their influence... by Ester Alves Mota (8474316)

Effect of MF (2 MT, 50 Hz) on VEGFR expression and activation. by Simona Delle Monache (402973)

“…<p>Protein of equal quantity was separated by 8% SDS-page and electroblotted on to a PVDF membrane. Representative blots show effects exerted by MF (2 mT, 50 Hz) on VEGFR2 total expression and phosphorylation after 1 h, 6 h and 12 h of exposure A). …”

ChemRich enrichment of the top 50 most changed metabolites for SCD. by Juliette Cooke (11402543)

During <i>LdCen^-/-</i> ID infection, neutrophil derived increased CCL3 recruits significantly higher number of dendritic cells attributed with proinflammatory phenotype... by Parna Bhattacharya (316881)

A small group of plains zebra taken at a real-world equivalent of 16.4 m as they may appear to a human (a,c,e) and lion (b,d,f) under photopic (bright; daylight), mesopic (dim; dus... by Amanda D. Melin (270203)

NBCe1 protein expression regulation by D₁-like (D₁R and D₅R) dopamine receptor agonist in hRPTCs carrying wild-type (WT) <i>SLC4A5</i>. by John J. Gildea (845025)

“…<p>NBCe1 protein expression is decreased following an increase in intracellular sodium (↑Na⁺) (10 μmol monensin/L, 24 h) (N = 4, *P<0.001 vs VEH, one-way ANOVA, Tukey’s test) in WT <i>SLC4A5</i> hRPTC. …”

50% reduction of kinesin-1 or dynein is sufficient to perturb neuronal growth. by Gary J. Iacobucci (192833)

“…<p>(<b>A</b>) Representative neuronal cultures expressing APP-YFP and APP-YFP with 50% genetic reduction of either kinesin-1 or dynein are shown at day 1 and day 2. …”

Table_1_Decrease in Admissions and Change in the Diagnostic Landscape in a Newborn Care Unit in Northern Ghana During the COVID-19 Pandemic.DOC by Alhassan Abdul-Mumin (5986151)

“…</p><p>Conclusion: We observed a marked decrease in admissions and change in the diagnosis landscape and related mortality during the pandemic. …”

Dependence of seizure transition times on (<i>dν</i>_<i>se</i>/<i>dt</i>)^−1/2 with the default parameters as in Table 1 and Δ ranges from 2 s to 50 s. by F. Deeba (8661837)

Responsiveness of WT and transgenic mice to two stage carcinogenesis protocol (DMBA/TPA). by Jian Fu (41067)

“…(B) SCC/papilloma ratio indicating a sharp decrease in K5-VILIP-1 with respect to WT mice (p<0.01). …”

Neural networks classify states which differ in neuronal activity levels using ensembles of neurons that increase/decrease their activity in each state. by Nicholas A. Frost (10739821)

“…As a result, there is an increase (neurons 51:100) or decrease (neurons 1:50) in activity levels in State B compared to State A. …”

NEURON computer modelling predicts increased electrical activity at rest and in response to hyperpolarizing pulses for three variants of Ca_V3.3 and quiescence at rest fo... by Yousra El Ghaleb (22075892)

<i>Vps34</i> KO MEFs show a decrease in LC3 conjugation and LC3 puncta formation upon starvation. by Kelly Devereaux (466106)

Development of lymphangioma in PAI-1 WT or PAI-1^−/− mice. by Françoise Bruyère (4734)

“…<p>A macroscopic decrease of lymphangioma is observed in PAI-1^−/− as compared to WT (A). …”