Table1_Nitazoxanide, an Antiprotozoal Drug, Reduces Bone Loss in Ovariectomized Mice by Inhibition of RANKL-Induced Osteoclastogenesis.docx by Chang-hong Li (11816780)

“…The present study found that NTZ potently inhibited osteoclast formation at the early stage of receptor activator of NF-κB ligand-induced osteoclastogenesis in a concentration-dependent manner at a non-growth inhibitory concentration. …”

Germ cell loss after Sertoli cell ablation in adulthood does not impact testicular architecture. by Diane Rebourcet (153547)

“…<p>(A) Testis weight is decreased at all ages following Sertoli cell ablation in adulthood (T-test n = 8–12, ****P<0.0001). …”

Comparison of simulated FRAP curves to experiment, using parameters from Table 1. by Hui Wang (30400)

“…<p>Curves are normalized to unity before simulated bleaching of a region near cell tips at . (A) FRAP curves as a function of decreasing active cytoplasmic actin concentration to simulate the effects of increasing doses of LatA. …”

Zebrafish Caudal Fin Angiogenesis Assay—Advanced Quantitative Assessment Including 3-Way Correlative Microscopy - Fig 4 by Ruslan Hlushchuk (56116)

“…<p><b>DAA: Assessment of the anti-angiogenic effects of PTK787 at different concentrations 50, 100, 250, 500 nM: a-c</b> Fluorescent images of regenerating caudal fins at 3 (<b>a</b>^<b>1</b><b>-c</b>^<b>1</b>), 5 (<b>a</b>^<b>2</b><b>-c</b>^<b>2</b>) and 7 dpa (<b>a</b>^<b>3</b><b>-c</b>^<b>3</b>) under 3 different conditions: vehicle control (left column), 100 nM (middle) and 500 nM PTK787 (right column). …”

Lumican modulates adipocyte function in obesity-associated type 2 diabetes by Clarissa Strieder-Barboza (4662910)

Male-biased effects of ubiquitous RNAi-mediated <i>bmm</i> inhibition reduces sex differences in triglyceride storage and breakdown. by Lianna W. Wat (8339454)

“…(K) Between 0 and 12 hours STV, triglyceride breakdown in <i>da>UAS-bmm-RNAi#2</i> (BDSC #25926) females was blocked, whereas triglyceride levels decreased in <i>da>+</i> and <i>+>UAS-bmm-RNAi#2</i> control females (<i>p</i> = 0.18, 0.036, and 9.9 × 10⁻⁵, respectively; one-way ANOVA followed by Tukey HSD test), whereas we observed similar magnitudes of triglyceride breakdown between 12 and 24 hours STV in <i>da>+</i>, <i>+>UAS-bmm-RNAi#2</i>, and <i>da>UAS-bmm-RNAi#2</i> (BDSC #25926) females (<i>p</i> = 0.032, 0.28, and 0.022, respectively; one-way ANOVA followed by Tukey HSD test). …”

4−AP does not affect closed−state inactivation in Kv2.1/Kv9.3 heterotetramers. by Jeroen I. Stas (818580)

“…(C−D) The normalized plot of induction at −45 mV (C) and recovery at −100 mV (D) of closed−state inactivation was obtained as described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0141349#pone.0141349.g004" target="_blank">Fig 4</a>. …”

Table 1_A murine model of gestational diabetes reveals MASLD risk and alterations in markers of hepatic mitochondrial metabolism.docx by Grace E. Shryack (21596426)

“…</p>Results<p>Progressing gestation in both CD and GDM dams significantly decreased protein and mRNA markers of hepatic mitochondrial biogenesis (Pgc1-α, Tfam), autophagy (Atg5, Sqstm1), mitophagy (Pink1, Bnip3) and lipid handling (Ampk, pAMPK/AMPK, FAS, ACC, pACC, Mttp) with a main effect for time (P<0.05). …”

Data_Sheet_1_Prevalence and incidence of stroke, white matter hyperintensities, and silent brain infarcts in patients with chronic heart failure: A systematic review, meta-analysis... by Sean Tan (13796668)

“…Meta-regression showed IS prevalence was positively correlated with decreasing anticoagulant usage.</p>Conclusion<p>We obtained estimates for the prevalence of IS, WMH, and SBI in HF from systematic review of the literature.…”

Revisiting the Conformation and Dynamics of DNA in Slitlike Confinement by Jing Tang (33607)

“…We measured the in-plane radius of gyration (<i>R</i>_∥), diffusivity (<i>D</i>), and longest relaxation time (τ) of λ-DNA (48.5 kbp) as functions of the slit height using fluorescence microscopy. …”

Revisiting the Conformation and Dynamics of DNA in Slitlike Confinement by Jing Tang (33607)

“…We measured the in-plane radius of gyration (<i>R</i>_∥), diffusivity (<i>D</i>), and longest relaxation time (τ) of λ-DNA (48.5 kbp) as functions of the slit height using fluorescence microscopy. …”

<i>pals-17</i> mutant phenotypes are fully <i>pals-16</i>-dependent. by Vladimir Lažetić (5047592)

“…<p>(A, B) <i>pals-16</i> RNAi decreases <i>pals-5</i>p::GFP expression in <i>pals-17 pals-20</i> mutants. …”

Effects of the Pgp inhibitor tariquidar (TQ; 0.5 µM) in three functional assays, in which alterations in Pgp efflux are indirectly measured by determining intracellular concentrati... by Andreas Noack (519906)

“…Much higher concentrations (100 µg/ml) of doxycycline have been shown to increase Pgp expression and functionality in MCF-7 breast carcinoma cells <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0088154#pone.0088154-Mealey1" target="_blank">[37]</a>. …”

Genetic Variants in the p14ARF/MDM2/TP53 Pathway Are Associated with the Prognosis of Esophageal Squamous Cell Carcinoma Patients Treated with Radical Resection by Jing Li (10611)

“…Moreover, patients with the DEL/A +AA genotype of <i>MDM2</i> rs34886328 had a notably increased OS (HR = 0.27, 95% CI: 0.13–0.56, <i>P</i> = 4.7×10⁻⁴, <i>Pc</i> = 0.003) and DFS (HR = 0.22, 95% CI: 0.11–0.43, <i>P</i> = 1.1×10⁻⁵, <i>Pc</i> = 6.6×10⁻⁵). We also found that these two SNPs had a cumulative effect on the prognosis of ESCC, with the OS (<i>P</i> < 0.001) and DFS (<i>P</i> < 0.001) being shortest for patients carrying both of these unfavorable genotypes. …”

Data_Sheet_4_Immune-Inflammatory Parameters in COVID-19 Cases: A Systematic Review and Meta-Analysis.DOC by Xudong Feng (1426792)

“…In addition, the WBC count>10 × 10⁹/L, lymphocyte count<1 × 10⁹/L, PCT>0.5 ng/mL, and CRP>10 mg/L were risk factors for disease progression in patients with COVID-19 (WBC count>10 × 10⁹/L: OR = 2.92, 95% CI: 1.96–4.35; lymphocyte count<1 × 10⁹/L: OR = 4.97, 95% CI: 3.53–6.99; PCT>0.5 ng/mL: OR = 6.33, 95% CI: 3.97–10.10; CRP>10 mg/L: OR = 3.51, 95% CI: 2.38–5.16). …”

Data_Sheet_1_Immune-Inflammatory Parameters in COVID-19 Cases: A Systematic Review and Meta-Analysis.DOC by Xudong Feng (1426792)

“…In addition, the WBC count>10 × 10⁹/L, lymphocyte count<1 × 10⁹/L, PCT>0.5 ng/mL, and CRP>10 mg/L were risk factors for disease progression in patients with COVID-19 (WBC count>10 × 10⁹/L: OR = 2.92, 95% CI: 1.96–4.35; lymphocyte count<1 × 10⁹/L: OR = 4.97, 95% CI: 3.53–6.99; PCT>0.5 ng/mL: OR = 6.33, 95% CI: 3.97–10.10; CRP>10 mg/L: OR = 3.51, 95% CI: 2.38–5.16). …”

Data_Sheet_3_Immune-Inflammatory Parameters in COVID-19 Cases: A Systematic Review and Meta-Analysis.DOCX by Xudong Feng (1426792)

“…In addition, the WBC count>10 × 10⁹/L, lymphocyte count<1 × 10⁹/L, PCT>0.5 ng/mL, and CRP>10 mg/L were risk factors for disease progression in patients with COVID-19 (WBC count>10 × 10⁹/L: OR = 2.92, 95% CI: 1.96–4.35; lymphocyte count<1 × 10⁹/L: OR = 4.97, 95% CI: 3.53–6.99; PCT>0.5 ng/mL: OR = 6.33, 95% CI: 3.97–10.10; CRP>10 mg/L: OR = 3.51, 95% CI: 2.38–5.16). …”

Data_Sheet_2_Immune-Inflammatory Parameters in COVID-19 Cases: A Systematic Review and Meta-Analysis.DOC by Xudong Feng (1426792)

“…In addition, the WBC count>10 × 10⁹/L, lymphocyte count<1 × 10⁹/L, PCT>0.5 ng/mL, and CRP>10 mg/L were risk factors for disease progression in patients with COVID-19 (WBC count>10 × 10⁹/L: OR = 2.92, 95% CI: 1.96–4.35; lymphocyte count<1 × 10⁹/L: OR = 4.97, 95% CI: 3.53–6.99; PCT>0.5 ng/mL: OR = 6.33, 95% CI: 3.97–10.10; CRP>10 mg/L: OR = 3.51, 95% CI: 2.38–5.16). …”

DataSheet_1_Immune Monitoring of Patients With Primary Immune Regulation Disorders Unravels Higher Frequencies of Follicular T Cells With Different Profiles That Associate With Alt... by María Soledad Caldirola (9575969)

“…To improve our understanding of these conditions, in this work we analyzed the T and B cell compartments of 15 PID patients with dysregulation, including 3 patients with STAT1 GOF mutation, 7 patients with CVID with dysregulation, 3 patients with mutations in CTLA4, 1 patient with CD25 mutation and 1 patient with STAT5b mutation and compared them with healthy donors and with CVID patients without dysregulation. …”

Severe Diaphragmatic Eventration by Domenico Calcaterra (4242838)

“…</p> <h3>Discussion</h3> <p>According to most authors, ‘true’ eventration is always a congenital condition due to a defect of development of one portion or the entire central part of the diaphragm [1-4] and is characterized by a membranous appearance of the muscle with a marked decrease in muscle fibers compared to the normal muscle [4, 5]. …”