TNFα promotes proliferation of human synovial MSCs while maintaining chondrogenic potential by Mikio Shioda (4033967)

“…<div><p>Synovial mesenchymal stem cells (MSCs) are a candidate cell source for cartilage and meniscus regeneration. If we can proliferate synovial MSCs more effectively, we can expand clinical applications to patients with large cartilage and meniscus lesions. …”

Table1_Humanized CXCL12 antibody delays onset and modulates immune response in alopecia areata mice: insights from single-cell RNA sequencing.xlsx by Seungchan An (6256061)

“…Gene ontology analysis revealed that immune cell chemotaxis and cellular response to type II interferon were upregulated in AA model but downregulated after Ab treatment. We further identified key immune cell-related genes such as Ifng, Cd8a, Ccr5, Ccl4, Ccl5, and Il21r, which were colocalized with Cxcr4 in T cells and regulated by CXCL12 Ab treatment. …”

A case study of density functional theory and domain-based local pair natural orbital coupled cluster for vibrational effects on EPR hyperfine coupling constants: vibrational pertu... by Alexander A. Auer (2348221)

“…Both approaches are found to yield very similar results for the spin probe 2,2,3,4,5,5-hexamethylperhydroimidazol-1-oxyl (HMI) and are both feasible for systems of around 30 atoms. …”

Supplementary Material for: Long-Term Follow-Up Changes of Central Choroidal Thickness Thinning after Repeated Anti-VEGF Therapy Injections in Patients with Central Retinal Vein Oc... by Kida T. (3351761)

“…At 1 month after treatment, VA had improved in 21 (77.8%) patients, and CRT had decreased in 25 (92.6%). At the final visit, 22 (81.5%) showed improved VA, 19 (70.4%) had resolved macular edema, and the CCT had gradually become thinner with additional drug injections in all the patients. …”

DataSheet_2_The influence of 17β-estradiol plus norethisterone acetate treatment on markers of glucose and insulin metabolism in women: a systematic review and meta-analysis of ran... by Weijuan Cui (15536306)

“…The combined administration of 17β-estradiol and norethisterone acetate decreased HbA1c (WMD: -0.65%, 95% CI: -1.15 to -0.15; P=0.011), fasting glucose (WMD: -11.05 mg/dL, 95% CI: -16.6 to -5.5; P<0.001) and insulin (WMD: -1.35 mIU/L, 95% CI: -2.20 to -0.50; P=0.001) levels. …”

Data_Sheet_1_Characterization of regulatory genes Plhffp and Plpif1 involved in conidiation regulation in Purpureocillium lavendulum.pdf by Yu Wei (365236)

“…Among these mutants, 131 strains exhibited abnormal conidiation, and further in-depth investigations were conducted on two strains (designated as #5-197 and #5-119) that showed significantly reduced conidiation. …”

Functional Characterization of an <em>Aspergillus fumigatus</em> Calcium Transporter (PmcA) that Is Essential for Fungal Infection by Taísa Magnani Dinamarco (162671)

“…CrzA-binding experiments suggested that the 5′-CACAGCCAC-3′ and 5′-CCCTGCCCC-3′ sequences upstream of <em>pmcA</em> and <em>pmcC</em> genes, respectively, are possible calcineurin-dependent response elements (CDREs)-like consensus motifs. …”

Image_4_HPV Induces Changes in Innate Immune and Adhesion Molecule Markers in Cervical Mucosa With Potential Impact on HIV Infection.pdf by Alan Messala A. Britto (6209393)

“…HPV infected patients expressed higher levels of TLR9 and lower levels of pattern recognition receptors that recognize RNA (TLR3, TLR7, and MDA5/IFIH1). We also detected an impaired IFN pathway, with an increased Type I IFN and a decreased IFNα2 receptor expression. …”

Table_1_Microbial community succession in the intestine of mice with deep partial-thickness burns.DOCX by Li-Jian Chen (3356018)

“…</p>Methods<p>In this study, we established a model of deep partial-thickness burn in mice and collected fecal samples at eight time points (pre-burn, 1, 3, 5, 7, 14, 21, and 28 days post-burn) for 16S rRNA amplification and high-throughput sequencing.…”

Multiple pathways of alveolar macrophage death contribute to pulmonary inflammation induced by silica nanoparticles by Eun-Jung Park (201821)

“…<p>In our previous study, 20 nm-sized amorphous silica nanoparticles (20-SiNPs), but not 50 nm-sized amorphous silica nanoparticles (50-SiNPs), induced pulmonary inflammatory response in rats exposed repeatedly for 14 days (12.5, 25, and 50 μg/time, total six times). In this study, we tried to clarify the causes of different responses induced by both SiNPs using mice (12.5, 25, and 50 μg/lung) and mouse alveolar macrophage cells. …”

Table_1_Continuous low-dose cyclophosphamide plus prednisone in the treatment of relapsed and refractory multiple myeloma with severe complications.xlsx by Haotian Shi (1467646)

“…In addition, we found the pro-BNP/BNP level was obviously decreased while the LVEF (left ventricular ejection fraction) was increased in RRMM patients following CP treatment as compared with those before treatment. …”

Table_2_HPV Induces Changes in Innate Immune and Adhesion Molecule Markers in Cervical Mucosa With Potential Impact on HIV Infection.docx by Alan Messala A. Britto (6209393)

“…HPV infected patients expressed higher levels of TLR9 and lower levels of pattern recognition receptors that recognize RNA (TLR3, TLR7, and MDA5/IFIH1). We also detected an impaired IFN pathway, with an increased Type I IFN and a decreased IFNα2 receptor expression. …”

Efficacy and safety of saxagliptin in combination with insulin in Japanese patients with type 2 diabetes mellitus: a 16-week double-blind randomized controlled trial with a 36-week... by Takashi Kadowaki (35402)

“…</p> <p><b>Research design and methods</b>: We randomized 240 patients with type 2 diabetes mellitus on insulin monotherapy to 5-mg saxagliptin or placebo as add-on therapy for a 16-week, double-blind period. …”

IL-7 producing immunotherapy improves <i>ex vivo</i> T cell functions of immunosenescent patients, especially post hip fracture by Chrystel Marton (9950893)

“…We assessed the impact of this encoded hIL-7 on the <i>ex vivo</i> immune functions of T cells from PBMC of immunosenescent patients with or without hip fracture. …”

Table_2_Sex and age effects on gray matter volume trajectories in young children with prenatal alcohol exposure.XLSX by Madison Long (18336297)

“…Using longitudinal T1-weighted MRI, the present study characterized gray matter volume development in young children with PAE (N = 42, 84 scans, ages 3–8 years) compared to unexposed children (N = 127, 450 scans, ages 2–8.5 years). Overall, we observed altered global and regional gray matter development trajectories in the PAE group, wherein they had attenuated age-related increases and more volume decreases relative to unexposed children. …”

Table_4_Sex and age effects on gray matter volume trajectories in young children with prenatal alcohol exposure.XLSX by Madison Long (18336297)

“…Using longitudinal T1-weighted MRI, the present study characterized gray matter volume development in young children with PAE (N = 42, 84 scans, ages 3–8 years) compared to unexposed children (N = 127, 450 scans, ages 2–8.5 years). Overall, we observed altered global and regional gray matter development trajectories in the PAE group, wherein they had attenuated age-related increases and more volume decreases relative to unexposed children. …”

Optimal Triage Test Characteristics to Improve the Cost-Effectiveness of the Xpert MTB/RIF Assay for TB Diagnosis: A Decision Analysis by Anna H. van’t Hoog (152398)

“…To inform the selection and development of particular diagnostics as a triage test we explored combinations of sensitivity, specificity and cost at which a hypothetical triage test will improve affordability of the Xpert assay.…”

Dengue in northeastern Brazil: a spatial and temporal perspective by Ana Beatriz Souza Martins (10372760)

“…The AAPC reduced over time (-9.5%; 95% confidance interval [CI]: -18.3; -0.3). …”

Table_1_Sex and age effects on gray matter volume trajectories in young children with prenatal alcohol exposure.XLSX by Madison Long (18336297)

“…Using longitudinal T1-weighted MRI, the present study characterized gray matter volume development in young children with PAE (N = 42, 84 scans, ages 3–8 years) compared to unexposed children (N = 127, 450 scans, ages 2–8.5 years). Overall, we observed altered global and regional gray matter development trajectories in the PAE group, wherein they had attenuated age-related increases and more volume decreases relative to unexposed children. …”

Data_Sheet_1_RNA Binding by the Campylobacter jejuni Post-transcriptional Regulator CsrA.pdf by Faiha M. El Abbar (7143620)

“…We performed saturating site-directed mutagenesis on C. jejuni CsrA and assessed the regulatory activity of these mutant proteins, using a reporter system encoding the 5′ untranslated region (5′ UTR) upstream of flaA linked translationally to the C. jejuni astA gene. …”