Table_2_Mendelian randomization in blood metabolites identifies triglycerides and fatty acids saturation level as associated traits linked to pancreatitis risk.xlsx by Jiarui Mi (11170284)

“…Next, we exploited the MR-BMA method to pinpoint the dominating factors on the increased risk of pancreatitis.…”

Table_3_Mendelian randomization in blood metabolites identifies triglycerides and fatty acids saturation level as associated traits linked to pancreatitis risk.xlsx by Jiarui Mi (11170284)

“…Next, we exploited the MR-BMA method to pinpoint the dominating factors on the increased risk of pancreatitis.…”

Controlling the Rigidity of Kinesin-Propelled Microtubules in an <i>In Vitro</i> Gliding Assay Using the Deep-Sea Osmolyte Trimethylamine <i>N</i>‑Oxide by Arif Md. Rashedul Kabir (7513523)

“…Based on this strategy, we are able to reduce the persistence length of microtubules, a measure of microtubule rigidity, ∼8 fold by using TMAO at the concentration of 1.5 M. …”

Epigenetic Regulations of Immediate Early Genes Expression Involved in Memory Formation by the Amyloid Precursor Protein of Alzheimer Disease by Aurélie Hendrickx (459302)

“…<div><p>We previously demonstrated that APP epigenetically regulates <i>Egr1</i> expression both in cultured neurons and <i>in vivo</i>. …”

Table_8_Mendelian randomization in blood metabolites identifies triglycerides and fatty acids saturation level as associated traits linked to pancreatitis risk.xlsx by Jiarui Mi (11170284)

“…Next, we exploited the MR-BMA method to pinpoint the dominating factors on the increased risk of pancreatitis.…”

<i>Bmp6</i> Expression Can Be Regulated Independently of Liver Iron in Mice by Zhuzhen Zhang (311660)

“…Furthermore, we also confirmed previous suggestions that Tf-bound iron regulates <i>Hamp1</i> expression via Smad1/5/8 phosphorylation without affecting <i>Bmp6</i> expression, and the effect of Tf-bound iron on <i>Hamp1</i> regulation appeared before a significant change in <i>Bmp6</i> expression. …”

Computing the Rotational Diffusion of Biomolecules via Molecular Dynamics Simulation and Quaternion Orientations by Po-chia Chen (1262706)

“…While <i>ab initio D</i>_rot prediction can be achieved by explicit all-atom molecular dynamics simulations, this is hindered by both computational expense and limitations in water models. We propose coarse-grained force fields as a complementary solution, and show that the MARTINI force field with elastic networks is sufficient to compute <i>D</i>_rot in >10 proteins spanning 5–157 kDa. …”

Image_1_Tumor Cell-Based Vaccine Generated With High Hydrostatic Pressure Synergizes With Radiotherapy by Generating a Favorable Anti-tumor Immune Microenvironment.TIF by Christoph Seitz (762554)

“…In B16-F10 tumors that were irradiated with 2 × 5Gy and vaccinated once with HHP-killed tumor cells, the amount of natural killer (NK) cells, monocytes/macrophages, CD4+ T cells and NKT cells was significantly increased, while the amount of B cells was significantly decreased. …”

Impact of Transcatheter Aortic Valve Implantation on Kidney Function by Rita Calça (7888694)

“…We analyzed the eGFR one month and one year after TAVI in these three groups, using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula to calculate it. …”

Computing the Rotational Diffusion of Biomolecules via Molecular Dynamics Simulation and Quaternion Orientations by Po-chia Chen (1262706)

“…While <i>ab initio D</i>_rot prediction can be achieved by explicit all-atom molecular dynamics simulations, this is hindered by both computational expense and limitations in water models. We propose coarse-grained force fields as a complementary solution, and show that the MARTINI force field with elastic networks is sufficient to compute <i>D</i>_rot in >10 proteins spanning 5–157 kDa. …”

Controlling the Rigidity of Kinesin-Propelled Microtubules in an <i>In Vitro</i> Gliding Assay Using the Deep-Sea Osmolyte Trimethylamine <i>N</i>‑Oxide by Arif Md. Rashedul Kabir (7513523)

“…Based on this strategy, we are able to reduce the persistence length of microtubules, a measure of microtubule rigidity, ∼8 fold by using TMAO at the concentration of 1.5 M. …”

DataSheet_3_Increased Expression of Mitochondrial UQCRC1 in Pancreatic Cancer Impairs Antitumor Immunity of Natural Killer Cells via Elevating Extracellular ATP.docx by Hui Cong (3909211)

“…Such UQCRC1-induced impairment of NK cells was mediated by eATP and its metabolite adenosine via P2Y11R and A_2AR, respectively. Mechanistically, we found the UQCRC1/eATP axis reduced the expression of chemokine CCL5 in cancer cells and altered the balance of activating receptor DNAM-1 and inhibitory receptor CD96 on NK-92MI cells, resulting in decreased chemotaxis and exhausted phenotype of NK-92MI cells. …”

Impact of Transcatheter Aortic Valve Implantation on Kidney Function by Rita Calça (7888694)

“…We analyzed the eGFR one month and one year after TAVI in these three groups, using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula to calculate it. …”

Data_Sheet_2_A Phosphoproteomics Study of the Soybean root necrosis 1 Mutant Revealed Type II Metacaspases Involved in Cell Death Pathway.docx by Feifei Wang (195514)

“…We identified 3,160 proteins. When the p-value was set at ≤0.05 and the fold change of protein accumulation between rn1 and T322 at ≥1.5 or ≤0.67, we detected 118 proteins that showed increased levels and 32 proteins decreased levels in rn1 as compared to that in T322. …”

Functional Trait Strategies of Trees in Dry and Wet Tropical Forests Are Similar but Differ in Their Consequences for Succession by Madelon Lohbeck (731258)

“…Species turnover with succession in dry forest largely relates to increasing water availability and in wet forest to decreasing light availability. We hypothesized that while functional trait trade-offs are similar in the two forest systems, the successful plant strategies in these communities will be different, as contrasting filters affect species turnover. …”

Dissecting <em>Phaseolus vulgaris</em> Innate Immune System against <em>Colletotrichum lindemuthianum</em> Infection by Paula Rodrigues Oblessuc (141400)

“…Based on experimental validation of gene expression, we propose that hypersensitive reaction as part of effector-triggered immunity may operate, at least in part, by down-regulating genes, such as <em>FLS2-like</em> and <em>MKK5-like</em>, putative orthologs of the Arabidopsis genes involved in pathogen perception and downstream signaling.…”

Table 1_Epigenetic age acceleration and neurotrophin signaling pathways in cancer-related cognitive impairment: a longitudinal, prospective cohort study.docx by Michael Sayer (11493436)

“…</p>Results<p>PhenoAge and GrimAge demonstrated significant age acceleration relative to non-cancer controls and worsening cognitive function symptoms, with accelerated GrimAge associated with decreasing BDNF levels. DMPs associated with 5 different cognitive function outcomes (FactCog Score, Response, Memory, Executive Function, Multi-Tasking) were mapped to genes within KEGG pathway HSA:04722 (Neurotrophin Signaling Pathway). …”

DataSheet_1_Soluble CD83 modulates human-monocyte-derived macrophages toward alternative phenotype, function, and metabolism.docx by Katrin Peckert-Maier (13211658)

“…We show that sCD83 strikingly increases the expression of inhibitory molecules including ILT-2 (immunoglobulin-like transcript 2), ILT-4, ILT-5, and CD163, whereas activation markers, such as MHC-II and MSR-1, were significantly downregulated. …”

Senescence Is More Important in the Natural Lives of Long- Than Short-Lived Mammals by Christopher Turbill (244271)

“…The slope of this relationship (0.353±0.052 s.e.m.), however, indicated that mammals with higher survival rates have a mean life span representing a greater fraction of their potential maximum life span: the ratio of maximum to mean life span decreased significantly from >10 in short-lived to ∼1.5 in long-lived mammal species.…”

Targeted Resequencing of the Pericentromere of Chromosome 2 Linked to Constitutional Delay of Growth and Puberty by Diana L. Cousminer (747917)

“…One gene, <i>DNAH6</i>, harbored 6 protein-altering low-frequency variants (< 6% in the Finnish population) in 10 of the CDGP probands. We sequenced an additional 135 unrelated Finnish CDGP subjects and utilized the unique Sequencing Initiative Suomi (SISu) population reference exome set to show that while 5 of these variants were present in the CDGP set, they were also present in the Finnish population at similar frequencies. …”