Electroretinography in NCBE-deficient mice indicates ON bipolar cell dysfunction. by Gerrit Hilgen (128467)

“…<p><i>A, D,</i> Representative single flash ERG recordings from NCBE WT (black) and KO (red) mice (age 12 months) for increasing intensities under dark-adapted (<b><i>A</i></b>, scotopic) and light-adapted (<b><i>D</i></b>, photopic) conditions. …”

Tg9949 mice are prone to neurological dysfunction but do not spontaneously generate prions. by David W. Colby (254454)

Deficiency of TLR3 results in increased mortality and increased viral replication following CB4 challenge. by Martin J. Richer (184399)

“…<p>A) WT NOD (solid grey line), TLR3KO (solid black line) and MyD88KO mice (dashed black line) were challenged with 400 pfu of CB4 and mortality was monitored. …”

Clinical and biochemical determinants of length of stay, readmission and recurrence in patients admitted with diabetic ketoacidosis by Fateen Ata (12217764)

“…Patients with a 6-month DKA recurrence, female gender and T1DM had higher odds of 12-month recurrence, whereas a consult with a diabetes educator at the index admission was associated with decreased odds of recurrence.…”

Restriction of Mitochondrial Oxidation of Glutamine or Fatty Acids Enhances Intracellular Growth of <i>Mycobacterium abscessus</i> in Macrophages by Jong-Seok Kim (19365328)

“…R-type Mab infections exhibited a marked decrease in glutamine reliance but enhanced metabolic flexibility and capacity. …”

Red Blood Cell Transfusion and Mortality in Trauma Patients: Risk-Stratified Analysis of an Observational Study by Pablo Perel (102217)

“…Transfusion was associated with an increase in all-cause mortality among patients with &lt;6% and 6%–20% predicted risk of death (odds ratio [OR] 5.40, 95% CI 4.08–7.13, <i>p&lt;</i>0.0001, and OR 2.31, 95% CI 1.96–2.73, <i>p&lt;</i>0.0001, respectively), but with a decrease in all-cause mortality in patients with &gt;50% predicted risk of death (OR 0.59, 95% CI 0.47–0.74, <i>p&lt;</i>0.0001). …”

Lengthened ependymal cilia and increased ciliary beating function and frequency in the Katnal2-KO brain. by Ryeonghwa Kang (6793046)

“…(H) A decreased speed of microbeads in AD + AV regions after a 10-min pretreatment of brain slices with pneumolysin (PNML; 0.5 μg/ml) (<i>n</i> = 40 beads from 3 mice for pneumolysin and control [without pneumolysin] groups, Mann–Whitney test). …”

Experience-dependent and temporally restricted serotonin signaling and synaptic glomeruli pruning. by Vanessa Kay Miller (19775496)

“…Two-way ANOVA with Tukey’s multiple comparison shows a highly significant decrease in the Or42a OSN innervation (<i>n</i> = 28/condition, <i>p</i> = 7.45 × 10⁻¹¹) and increase in serotonin (<i>n</i> = 28/condition, <i>p</i> = 4.10 × 10⁻¹⁴). …”

The kava root extract and kavalactones down-regulate expression of AR and AR target genes (<i>PSA</i> and <i>TMPRSS2</i>) via accelerating the degradation of AR protein. by Xuesen Li (48046)

“…C4-2B cells were pretreated with 10 µg/ml cycloheximide for 2 hours and then supplemented with kava root extract or 5′6;-dehydrokawain at a concentration of their IC_{50 s} for different periods of time. …”

Serum-differentiation leads to enhanced MMP9 expression. by Justin V. Joseph (697904)

“…</b> Western blot showing a decrease in MMP9 expression in differentiated GG16 cells following the administration of CP 471474, a chemical inhibitor of MMP9. …”

Changes in economic decisions in an increasingly reward-scarce environment. by Brian M. Sweis (5434976)

“…Transition to the 1–30 s block caused a significant decrease in food intake and reinforcement rate. …”

Decision boundary dynamics modulated by theta activity. by Nadja R. Ging-Jehli (10925910)

“…<p><b>(A)</b> Exemplified scheme for integrating mean activation in theta-frequency band during pre-response (z-scored mean activation during the last 500 ms before response) and poststimulus (z-scored mean activation during the first 500 ms after stimulus onset) periods as trial-based neural regressors into the best-fitting model. …”

Global divergent responses of soil heterotrophic respiration to nitrogen deposition by Peng Guo (13816147)

“…Δ<i>R</i>_H significantly increased in alkaline soils (pH > 7.5) but decreased in acidic soils (pH < 5.5). Furthermore, Δ<i>R</i>_H significantly increased in soils with high total organic carbon (TOC > 15 g/kg) or low available N contents (NH4+ < 19 mg/kg or NO3− < 15 mg/kg), but decreased in soils with high total N (TN > 11 g/kg). …”

The effect of mutation rate variation. by Thomas Mailund (51584)

“…<p>The figure shows the effect on parameter estimation when the mutation rate is varied along the genome alignment. We split the alignment into segments geometrically distributed with mean length 500 bp and 2 kbp, and the mutation rate is then scaled by a random value chosen uniformly in the range 0.75 to 1.25 or 0.5 to 1.5. …”

Data_Sheet_1_Saccharification Potential of Transgenic Greenhouse- and Field-Grown Aspen Engineered for Reduced Xylan Acetylation.xlsx by Sivan Pramod (11401511)

“…<p>High acetylation of xylan in hardwoods decreases their value as biorefinery feedstocks. To counter this problem, we have constitutively suppressed RWA genes encoding acetyl-CoA transporters using the 35S promoter, or constitutively and wood-specifically (using the WP promoter) expressed fungal acetyl xylan esterases of families CE1 (AnAXE1) and CE5 (HjAXE), to reduce acetylation in hybrid aspen. …”

Arginine 58 is indispensable for proper function of the <i>Francisella tularensis</i> subsp. <i>holarctica</i> FSC200 HU protein, and its substitution alters virulence and mediates... by Pavla Pavlik (13953195)

The CCDC66 depletion disrupts normal tissue organization and signaling in 3D and 2D cultures. by Jovana Deretic (13113617)

“…Mean cilia percentage is 59.78 for shControl and 53.80 for shCcdc66, with a fold change decrease of 0.90. …”

DataSheet_1_Persistent T cell-mediated immune responses against Omicron variants after the third COVID-19 mRNA vaccine dose.docx by Milja Belik (14490191)

“…However, concerns have been raised due to decreasing neutralizing antibody levels after COVID-19 vaccination and due to the emergence of new immuno-evasive SARS-CoV-2 variants that may require additional booster vaccinations.…”

Insulin sensitizer effects in wild type and knockdown flies. by Jerry R. Colca (409220)

“…(<b>B</b>) Effect of incubation with DMSO, MSDC-1473 or MSDC-0160 on the amount of insulin-stimulated phosphorylation of AKT under the high sucrose conditions (detected and analyzed as in A; mean and SE, N = 3). (<b>C</b>) Wild-type female flies or flies with knockdown of CG14290 (as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0061551#pone-0061551-g005" target="_blank">Figure 5</a>) were raised on a 0.75M sucrose matrix and aged for 7 days with or without MSDC-0160 added to the matrix. …”

HO-1 deficiency leads to poor bacterial clearance <i>in vivo</i> and <i>in vitro</i>. by Satindra Gahlot (3615662)

“…Cultures were harvested after 24 hours and plated on Muller Hinton agar plates with 1:10, 1:100 and 1:1000 dilutions and CFU of MRSA was determined by counting next day. Data are means ±SD of 3 independent experiments. Statistical significance *p<0.001 a significant decrease compared to MRSA alone exposed cultures; and #p<0.001 a significant increase compared to MRSA +CoPP treated cultures. …”