Oxytocin reinstates fictive locomotor oscillations, despite subthreshold concentrations of neurochemicals. by Francesco Dose (540963)

“…A further decrease in NMDA (1.5 μM) + 5HT (4 μM) suppresses locomotor-like discharges, which are finally replaced by a tonic activity (C). …”

The initial values of densities of bone cells and MM cells in the MM-bone model. by Yan Wang (15435)

“…Given that MM is generally occurred in the elder people and BMSC percentage in bone marrow decreases to 1/2×10⁶ in elder people aged 80 <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0027494#pone.0027494-Caplan1" target="_blank">[21]</a>, the estimated BMSC number is corrected to ¼ of the number in adults, namely 5.12×10⁶ (#).…”

Comparison of coccolith size response (percentage change) across <i>E</i>. <i>huxleyi</i> strains under experimental high and low salinity conditions. by Christina Gebühr (10131419)

“…The dashed vertical line in (A) and (B) denotes the 5% decrease or increase in <i>C</i>_<i>L</i>, respectively, for guidance. …”

Combination of Merocel sponge with Lipopolysaccharide to establish rat rhinosinusitis model by Mengmeng Sun (3844750)

“…Results We found that compared with the control group and LPS group, the sinusitis symptom scores in the Merocel sponge combined with LPS group were significantly increased; the respiratory epithelia of the maxillary sinus were degenerated, cilia were detached, and even inflammatory cell infiltration occurred; the levels of TNF-α and IL-6 were increased; the expression of AQP5 and Occludin protein was decreased; and the expressions of TLR4, MyD88, and p-p65 protein were increased. …”

Frequency Dependent Alterations in Regional Homogeneity of Baseline Brain Activity in Schizophrenia by Rongjun Yu (277015)

“…While functional connectivity can reveal the synchronization between distant brain regions, the regional abnormalities in task-independent baseline brain activity are less clear, especially in specific frequency bands. Here, we used a regional homogeneity (ReHo) method combined with resting-state functional magnetic resonance imaging to investigate low frequency spontaneous neural activity in the three different frequency bands (slow-5∶0.01–0.027 Hz; slow-4∶0.027–0.08 Hz; and typical band: 0.01–0.08 Hz) in 69 patients with schizophrenia and 62 healthy controls. …”

Data_Sheet_1_Trajectories of (Bio)markers During the Development of Cognitive Frailty in the Doetinchem Cohort Study.pdf by M. Liset Rietman (6760496)

“…For the current analyses, we used data of 17 potentially relevant (bio)markers (e.g., body mass index (BMI), urea) from rounds 2 to 5 (1993–2012). …”

Distinct MicroRNAs Expression Profile in Primary Biliary Cirrhosis and Evaluation of miR 505-3p and miR197-3p as Novel Biomarkers by Masashi Ninomiya (209227)

“…Additionally, the circulating levels of hsa-miR-505-3p, 197-3p, and 500a-3p were significantly decreased in PBC compared with healthy controls and the expression levels of hsa-miR-505-3p, 139-5p and 197-3p were significantly reduced compared with the viral hepatitis group.…”

Data_Sheet_2_Trajectories of (Bio)markers During the Development of Cognitive Frailty in the Doetinchem Cohort Study.pdf by M. Liset Rietman (6760496)

“…For the current analyses, we used data of 17 potentially relevant (bio)markers (e.g., body mass index (BMI), urea) from rounds 2 to 5 (1993–2012). …”

Clusterin expression can be modulated by changes in TCF1-mediated Wnt signaling-6 by Troels Schepeler (79446)

Data_Sheet_1_Tiotropium and Fluticasone Inhibit Rhinovirus-Induced Mucin Production via Multiple Mechanisms in Differentiated Airway Epithelial Cells.docx by Ying Wang (11406)

“…Here we demonstrate that both HRV-A16 and HRV-1B increased mucin (MUC5AC and MUC5B) gene expression and protein release. …”

Simulated temporal dynamics in E2F activation using the stochastic Rb-E2F model. by Tae J. Lee (241477)

“…In contrast to the stochastic simulations, the deterministic simulation has the same trajectory for a given set of parameters (black line). (B) The percentage of G0 cells over time (G0 exit curve) is plotted for a population of 5,000 simulated cells stimulated at strong (red line, S = 5) and weak (blue line, S = 0.5) input concentrations. …”

Table2_Aquilaria sinensis leaf tea affects the immune system and increases sleep in zebrafish.XLSX by Xiaohui Tan (654208)

“…Transcriptome sequencing and qRT-PCR analysis revealed a decrease in the immune-related genes, such as nfkbiab, tnfrsf1a, nfkbiaa, il1b, traf3, and cd40 in the 1.5 g/L Aquilaria sinensis leaf tea treatment group. …”

Table1_Aquilaria sinensis leaf tea affects the immune system and increases sleep in zebrafish.XLSX by Xiaohui Tan (654208)

“…Transcriptome sequencing and qRT-PCR analysis revealed a decrease in the immune-related genes, such as nfkbiab, tnfrsf1a, nfkbiaa, il1b, traf3, and cd40 in the 1.5 g/L Aquilaria sinensis leaf tea treatment group. …”

Constant STAT3 and STAT1 activation in non-CIC and no STAT1 activation in CIC. by Laura Ahtiainen (238085)

“…Jurkat cells infected with Ad5/3-Delta24 are a positive control (A). (B) In JIMT-1 CD44⁺/CD24^−/low CIC population there is constant expression of STAT1 however no active P-STAT1 is detected up to 4 h. …”

Molecular Insight into the Slipperiness of Ice by Bart Weber (5226785)

“…Very low friction is only found over the limited temperature range typical for ice skating. The strong decrease in the friction coefficient with increasing temperature exhibits Arrhenius behavior with an activation energy of <i>E</i>_a ≈ 11.5 kJ mol^–1. …”

Image_1_Short-term effects of ophthalmic topical 0.01% atropine on the ocular surface, pupil size, and subsequent subjective quality of vision in young myopic Chinese adults.jpg by Mingze Li (4020185)

“…</p>Results<p>Following the use of 0.01% atropine, PPD significantly increased at all the time points (p < 0.001); MPD increased significantly at 10 h and 14 h (p < 0.001 and p < 0.05, respectively). A decrease in TMH and an increase in the OSDI questionnaire scores were observed up to 10 and 14 h, respectively, after using atropine (p < 0.001). …”

Trends in China’s anthropogenic emissions since 2010 as the consequence of clean air actions by Bo Zheng (5701343)

“…The emission reduction rates markedly accelerated after the year 2013, confirming the effectiveness of China’s Clean Air Action that was implemented in 2013. We estimated that during 2013–2017, China’s anthropogenic emissions decreased by 59% for SO2, 21% for NOx, 23% for CO, 36% for PM10, 33% for PM2.5, 28% for BC, and 32% for OC. …”

DataSheet1_Compounds Isolated from Wikstroemia taiwanensis Regulate Bone Remodeling by Modulating Osteoblast and Osteoclast Activities.docx by Zuha Imtiyaz (11119893)

“…Specifically, astragalin (1) and kaempferol 3-O-β-D-apiofuranosyl-(1→6)-β-D-glucopyranoside (2), besides increasing mineral deposition, increased alkaline phosphatase activity (137.2% for 1 and 115.8% for 2) and ESR-α expression (112.8% for 1 and 122.5% for 2) in primary human osteoblasts. In contrast, compounds 1, 2, 3, and 5 inhibited tartrate-resistant acid phosphatase (TRAP) activity in receptor activator of nuclear factor-κB ligand-induced osteoclasts by 40.8, 17.1, 25.9, and 14.5% and also decreased the number of TRAP-positive cells by 51.6, 26.8, 20.5, and 18.6%, respectively. …”

DataSheet1_Compounds Isolated from Wikstroemia taiwanensisRegulate Bone Remodeling by Modulating Osteoblast and Osteoclast Activities.docx by Zuha Imtiyaz (11119893)

“…Specifically, astragalin (1) and kaempferol 3-O-β-D-apiofuranosyl-(1→6)-β-D-glucopyranoside (2), besides increasing mineral deposition, increased alkaline phosphatase activity (137.2% for 1 and 115.8% for 2) and ESR-α expression (112.8% for 1 and 122.5% for 2) in primary human osteoblasts. In contrast, compounds 1, 2, 3, and 5 inhibited tartrate-resistant acid phosphatase (TRAP) activity in receptor activator of nuclear factor-κB ligand-induced osteoclasts by 40.8, 17.1, 25.9, and 14.5% and also decreased the number of TRAP-positive cells by 51.6, 26.8, 20.5, and 18.6%, respectively. …”

Resistin in Dairy Cows: Plasma Concentrations during Early Lactation, Expression and Potential Role in Adipose Tissue by Maxime Reverchon (544106)

“…<div><p>Resistin is an adipokine that has been implicated in energy metabolism regulation in rodents but has been little studied in dairy cows. We determined plasma resistin concentrations in early lactation in dairy cows and investigated the levels of resistin mRNA and protein in adipose tissue and the phosphorylation of several components of insulin signaling pathways one week post partum (1 WPP) and at five months of gestation (5 MG). …”