New Targets for Drug Discovery against Malaria by Guido Santos (171018)

“…The potential targets include: 1) increasing the death rate of the gametocytes, 2) decreasing the invasion rate of the red blood cells by the merozoites, 3) increasing the transformation of merozoites into gametocytes, 4) decreasing the activation of the immune system by the gametocytes, and finally 5) a combination of the previous target with decreasing the recycling rate of the red blood cells. …”

Influence of population and exercise protocol characteristics on hemodynamic determinants of post-aerobic exercise hypotension by L.C. Brito (6936437)

“…Data analysis showed that 1) most postexercise hypotension cases are due to a reduction in systemic vascular resistance; 2) age, body mass index, and blood pressure status influence postexercise hemodynamics, favoring cardiac output decrease in elderly, overweight, and hypertensive subjects; 3) gender and training status do not have an isolated influence; 4) exercise duration, intensity, and mode also do not affect postexercise hemodynamics; 5) time of day might have an influence, but more data are needed; and 6) recovery in the supine position facilitates systemic vascular resistance decrease. …”

image_1.jpeg by Monique Mendelson (4873582)

“…For exercise training, six randomized trials were included. There was a significant decrease in apnea–hypopnea-index following exercise training (mean decrease of 8.9 events/h; 95% CI: −13.4 to −4.3; p < 0.01), which was accompanied by a reduction in subjective sleepiness, an increase in VO2peak and no change in BMI. …”

The significance of ANXA4-induced gene expression was analyzed using the Ingenuity Pathway Analysis (IPA) database. by Li-Ling Lin (137084)

“…<p>(A) 25 of the 42 candidate genes showed a significant difference in expression (a fold increase of ≥2 or a fold decrease of ≤0.5, <i>P</i><0.05) and were categorized among the three top-ranked networks. …”

Mean number of high-risk/high-return choices across trials along with standard deviations. by Yuji Takano (252785)

“…<p>A total of 100 trials were divided into 5 blocks of 20 trials. …”

Top-Down Lipidomics Reveals Ether Lipid Deficiency in Blood Plasma of Hypertensive Patients by Juergen Graessler (261978)

“…Importantly, we observed that in blood plasma of hypertensive individuals the overall content of ether lipids decreased. …”

Filtration of Macrophage Migration Inhibitory Factor (MIF) in Patients with End Stage Renal Disease Undergoing Hemodialysis by Peter Luedike (816009)

“…MIF plasma levels were markedly decreased 2 hour after initiation of HD (MIF plasma level pre-HD 84.8±6 ng/ml to intra-HD 61.2±5 ng/ml p<0.001) and were replenished already 20 min after termination of HD to basal levels (intra-HD 61.2±5 ng/ml to post-HD 79.8±5 ng/ml, p<0.001).…”

ROS is the major player in regulating altered autophagy and lifespan in <i>sin-3</i> mutants of <i>C. elegans</i> by Meenakshi Sharma (107997)

“…In this study using a <i>Caenorhabditis elegans sin-3(tm1279);him-5(e1490)</i> strain, we demonstrate that under <i>in vivo</i> conditions SIN-3 differentially modulates autophagy and lifespan. …”

Video_2_Competitive Drivers of Atrial Fibrillation: The Interplay Between Focal Drivers and Multiwavelet Reentry.MP4 by Richard T. Carrick (10307162)

“…Background<p>There is debate whether human atrial fibrillation is driven by focal drivers or multiwavelet reentry. We propose that the changing activation sequences surrounding a focal driver can at times self-sustain in the absence of that driver. …”

Video_1_Competitive Drivers of Atrial Fibrillation: The Interplay Between Focal Drivers and Multiwavelet Reentry.MP4 by Richard T. Carrick (10307162)

“…Background<p>There is debate whether human atrial fibrillation is driven by focal drivers or multiwavelet reentry. We propose that the changing activation sequences surrounding a focal driver can at times self-sustain in the absence of that driver. …”

Video_3_Competitive Drivers of Atrial Fibrillation: The Interplay Between Focal Drivers and Multiwavelet Reentry.MP4 by Richard T. Carrick (10307162)

“…Background<p>There is debate whether human atrial fibrillation is driven by focal drivers or multiwavelet reentry. We propose that the changing activation sequences surrounding a focal driver can at times self-sustain in the absence of that driver. …”

Association of Nd:YAG laser and calcium-phosphate desensitizing pastes on dentin permeability and tubule occlusion by Vinícius MAXIMIANO (12833560)

“…Specimens underwent a 5-day erosion-abrasion cycling. Hydraulic conductance was measured post-EDTA, post-treatment, and post-cycling. …”

Supplementary Material for: Divergence and Convergence: How Do Income Inequalities in Mortality Change over the Life Course? by Rehnberg J. (6198179)

“…<b><i>Methods:</i></b> We used Swedish total population data with 5,011,414 individual observations. …”

Reduced control model M4: Normative evidence accumulation. by Veith Weilnhammer (2909060)

“…<p>When simulating data for the <i>normative-evidence-accumulation model</i>, we removed the oscillation from the likelihood and prior terms by setting the amplitudes <i>a</i>_<i>LLR</i> and <i>a</i>_<i>ψ</i> to 0. …”

Phenotypes associated with lifespan extension and stress resistance are observed in <i>hyl-1;lagr-1</i>. by Mai-Britt Mosbech (435186)

“…Compared to N2 displaying a mean pumping rate of 201±2 pumps/min, <i>hyl-1;lagr-1</i> shows a 17.4% decrease with a mean pumping rate of 166±2, P<0.0001, while <i>eat-2</i> shows a 67.2% decrease with a mean pumping rate of 66±3, P<0.0001. …”

Effect of the Cantareira System on the flow regime in Piracicaba River basin by Aline Frederice (6131282)

<i>Pocillopora</i> spp. corallum and corallite Random Forest model and Principal component analysis. by Guinther Mitushasi (21567784)

“…Confidence of prediction is represented in A as alpha gradient (0–1). (C) <i>Pocillopora</i> corallum and corallite model’s variables of importance; mean decrease accuracy and mean decrease Gini are shown as black and white squares, respectively. …”

Efficacy of HepG2-Fluidised-bed bioreactor treatment in pigs with ischaemic acute liver failure: biochemical response. by Clare Selden (453350)

“…Concomitant with a decrease in ICP in Group 1, ammonia levels decreased (cell BAL) cf. group 2 (Control empty bead BAL); Group 1 n = 6, mean 120±8; Group 2 n = 7, mean 150±11. …”

DataSheet_1_Dynamic alterations in PD-1/PD-L1 expression level and immune cell profiles based on radiation response status in mouse tumor model.docx by Yi Na Yoon (9434441)

“…RT with 2 Gy × 5 induced a higher frequency of PD-L1+ myeloid-derived suppressor cells, with a lesser degree of tumor regression, compared to 7.5 Gy. …”

P-TEFb and the Super Elongation Complex (SEC) display similar phenotypes. by Olle Dahlberg (645665)

“…<p>(<b>A</b>) RNA <i>in situ</i> hybridization using a digoxigenin-labeled <i>Serendipity-α (Sry-α)</i> probe demonstrates decreased levels of <i>Sry-α</i>mRNA in embryos depleted of maternal Cdk9 (ii) or Cyclin T (iii) compared to wild-type (i). …”