image_1_Treatment Intensification in HIV-Infected Patients Is Associated With Reduced Frequencies of Regulatory T Cells.PDF by Eva M. Grützner (5153150)

“…Treatment strategies to avoid the induction of these cells preserve immune functions and are therefore the object of intense research efforts. In this study, we assessed the effect of treatment intensification [=5-drug antiretroviral therapy (ART)] on the development of suppressive cell subsets. …”

Mutation rates across 60 <i>C</i>. <i>elegans</i> genotypes stratified by mutation type: Base substitutions, indels, and structural variants. by Bettina Meier (274833)

“…Error bars show the 95% confidence intervals; large dots represent variants with 2-fold increased or decreased mutation rates over N2 wild-type which are statistically significant with a false discovery rate (FDR) below 5%. …”

Met4 binding by Cbf1 and Met31 is dependent upon ordering but not orientation. by Ryan K. Shultzaberger (24946)

“…For columns 10–13 (marked with a blue box) we expect regulated genes to have a decreased expression and therefore to be green. …”

Knockdown of α-actinin-2 prevents spine maturation in response to NMDA receptor activation. by Jennifer L. Hodges (207936)

“…<p><b>A)</b> When α-actinin-2 is knocked down, spines do not shorten or assume a “mushroom” morphology in response to glycine. …”

Table 1_In Vitro biomechanical study of meniscal properties in patients with severe knee osteoarthritis.xlsx by Yuqi Liu (501183)

“…Both tensile and compressive moduli exhibited a stepwise decrease with increasing degeneration. …”

Table 2_In Vitro biomechanical study of meniscal properties in patients with severe knee osteoarthritis.xlsx by Yuqi Liu (501183)

“…Both tensile and compressive moduli exhibited a stepwise decrease with increasing degeneration. …”

Effects of PD-0332991 on BSG cell lines derived from genetically engineered mouse models. by Kelly L. Barton (465812)

“…<p>Cells were treated with PD-0332991 for 48 hours before being harvested for MTT or BrdU assays to assess cell survival and proliferation, respectively. (A) MTT assays (left panel) show minimal cytotoxic activity at doses up to 5µM in cell lines derived from PDGF-B; Ink4a-ARF deficient BSGs. …”

<i>CABLES1</i> expression is reduced in human subcutaneous adipose tissue in obesity and type 2 diabetes but may not directly impact adipocyte glucose and lipid metabolism by Susanne Hetty (7587506)

“…<p>Cdk5 and Abl enzyme substrate 1 (CABLES1) is a cell cycle regulator that has previously been identified as a candidate gene for obesity-related phenotypes, but little is known about its role in adipose tissue metabolism. …”

Charge Profile Analysis Reveals That Activation of Pro-apoptotic Regulators Bax and Bak Relies on Charge Transfer Mediated Allosteric Regulation by Crina-Maria Ionescu (158447)

“…The network was mediated by a hub of three residues on helix 5 of the hydrophobic core of Bax. …”

S1 Fig - by Jérémie Le Pen (18551533)

“…However, it appears that (i) IFITM2 restricts WT SARS-CoV-2 endosomal entry [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002767#pbio.3002767.ref122" target="_blank">122</a>], (ii) recent SARS-CoV-2 variants may evade IFITM2 [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002767#pbio.3002767.ref199" target="_blank">199</a>], and (iii) IFITM3 KO mice are hypersusceptible to WT SARS-CoV-2 [<a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002767#pbio.3002767.ref206" target="_blank">206</a>]. …”

Table_1_Absence of Thyroid Hormone Induced Delayed Dendritic Arborization in Mouse Primary Hippocampal Neurons Through Insufficient Expression of Brain-Derived Neurotrophic Factor.... by Hiroyuki Yajima (2108134)

“…Addition of 10 ng/ml BDNF recovered the suppressed dendrite arborization induced by T₃ deficiency on 10 DIV. We show that the lack of TH induces a developmental delay in primary hippocampal neurons, likely caused through a decreased Bdnf expression. …”

DataSheet_1_Absence of Thyroid Hormone Induced Delayed Dendritic Arborization in Mouse Primary Hippocampal Neurons Through Insufficient Expression of Brain-Derived Neurotrophic Fac... by Hiroyuki Yajima (2108134)

“…Addition of 10 ng/ml BDNF recovered the suppressed dendrite arborization induced by T₃ deficiency on 10 DIV. We show that the lack of TH induces a developmental delay in primary hippocampal neurons, likely caused through a decreased Bdnf expression. …”

Data Sheet 2_Predicting mortality in heart failure: BUN/creatinine ratio in MIMIC-III.docx by Changsen Zhu (20821991)

“…Nonlinear regression revealed a U-shaped relationship between BCR and mortality: at BCR levels below 12.5, there was no significant correlation with long-term mortality; between 12.5 and 22, BCR appeared to exert a protective effect; and above 22, it emerged as a significant risk factor.…”

Lactate Dehydrogenase B Is Associated with the Response to Neoadjuvant Chemotherapy in Oral Squamous Cell Carcinoma by Wenyi Sun (738952)

“…Neoadjuvant chemotherapy regimens of docetaxel, cisplatin and 5-fluorouracil (TPF) are currently accepted as standard regimens for HNSCC patients with a high risk of distant metastatic spread. …”

Equations and graphs illustrating the effect of tree size and competition on demographic rates. by John P. Caspersen (150918)

“…The effect of diameter on longevity (<i>L_S(D)</i>, middle left) is specified as the product of an increasing power function and a decreasing logistic function (grey dashed lines). …”

Data Sheet 1_Predicting mortality in heart failure: BUN/creatinine ratio in MIMIC-III.csv by Changsen Zhu (20821991)

“…Nonlinear regression revealed a U-shaped relationship between BCR and mortality: at BCR levels below 12.5, there was no significant correlation with long-term mortality; between 12.5 and 22, BCR appeared to exert a protective effect; and above 22, it emerged as a significant risk factor.…”

The Mitochondrial Peptidase Pitrilysin Degrades Islet Amyloid Polypeptide in Beta-Cells by Hanjun Guan (772609)

“…In insulinoma cells when pitrilysin expression was decreased to 5% of normal levels, there was a 60% increase in islet amyloid polypeptide-induced apoptosis. …”

Cleavage of BID, loss of MMP, change in expression of anti- and pro-apoptotic proteins. by Radha Pujari (484718)

“…<p>(A) Molt-4 cells were treated with RBL (5 µg/ml) for different time periods and the effect on 21kDa uncleaved Bid was studied by western blot analysis. …”

ICC results of Elk1 and Elk1-3R effects on endogenous katanin-p60 level. by Dolunay Kelle (6388055)

“…(B) Relative fluorescence density graph shows that the expression of katanin-p60 was 5.5 fold decreased in Elk1 overexpressed cells compared to control cells. …”

Summary of anxiogenic and anxiolytic modulation of adult zebrafish behavior in standard 6-min novel tank test (see Fig. S1 in Supplementary Materials for raw data from these experi... by Jonathan Cachat (377024)

“…Statistically significant differences from matched controls (p<0.05, U-test) are represented by solid arrows (empty arrows denote trends; p = 0.05–0.085, U-test): up – increase, down – decrease; empty fields indicate no significant effects, n/a – data not available. …”