Showing 741 - 760 results of 99,993 for search '(( 5 ((wt decrease) OR (we decrease)) ) OR ( 5 ((a decrease) OR (nn decrease)) ))', query time: 1.06s Refine Results
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    LC–MS/MS analysis of 5-, 8-, 11-, 12- and 15-HETE levels in WT and Tie2-CYP2J2 Tr mouse heart perfusates at baseline and post-ischemia. by Ahmad Hanif (3094800)

    Published 2017
    “…In both WT and Tie2-CYP2J2 Tr mice, post-ischemic levels of 5-HETE (A), 8-HETE (B), 11-HETE (C), 12-HETE (D) and 15-HETE (E) were decreased compared to baseline levels (<i>P</i> < 0.05). * <i>P</i> < 0.05 versus baseline WT. # <i>P</i> < 0.05 versus WT post-ischemia. …”
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    SIVcol Nef counteracts SERINC5 by promoting its proteasomal degradation but does not efficiently enhance HIV-1 replication in human CD4+ T cells and lymphoid tissue by Dorota Kmiec (5646374)

    Published 2018
    “…Here, we show that the Nef protein of the highly divergent SIVcol lineage infecting mantled guerezas (<i>Colobus guereza</i>) is a potent antagonist of SERINC5, although it lacks the CD4, CD3 and CD28 down-modulation activities exerted by other primate lentiviral Nefs. …”
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    Pharmacological Mechanism of the Non-hallucinogenic 5‑HT<sub>2A</sub> Agonist Ariadne and Analogs by Michael J. Cunningham (14267038)

    Published 2022
    “…Compared to DOM, Ariadne shows lower signaling potency and efficacy in multiple signaling pathways examined (G<sub>q</sub>, G<sub>11</sub>, and β-arrestin2) coupled to 5-HT<sub>2A</sub> receptors. We confirmed the shift in signaling for an α-propyl analog and provide a molecular docking rationale for the progressive decrease in signaling potency with the growing length of the α-substituent. …”
  14. 754

    Pharmacological Mechanism of the Non-hallucinogenic 5‑HT<sub>2A</sub> Agonist Ariadne and Analogs by Michael J. Cunningham (14267038)

    Published 2022
    “…Compared to DOM, Ariadne shows lower signaling potency and efficacy in multiple signaling pathways examined (G<sub>q</sub>, G<sub>11</sub>, and β-arrestin2) coupled to 5-HT<sub>2A</sub> receptors. We confirmed the shift in signaling for an α-propyl analog and provide a molecular docking rationale for the progressive decrease in signaling potency with the growing length of the α-substituent. …”
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