Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

Development of Selective and Soluble Mitochondrial Complex 1 Inhibitors Derived from Papaverine for Radiosensitization of Cancer by Ben J. Haines (22458462)

Development of Selective and Soluble Mitochondrial Complex 1 Inhibitors Derived from Papaverine for Radiosensitization of Cancer by Ben J. Haines (22458462)

Decreased Memory B Cells and Increased CD8 Memory T Cells in Blood of Breastfed Children: The Generation R Study by Michelle A. E. Jansen (740955)

“…</p><p>Results</p><p>Per month continuation of breastfeeding, a 3% (95% CI -6, -1) decrease in CD27+IgM+, a 2% (95 CI % -5, -1) decrease in CD27+IgA+ and a 2% (95% CI -4, -1) decrease in CD27-IgG+ memory B cell numbers were observed at 6 months of age. …”

Parkin decreases total and cell surface expressed Ca_V2.2 channels. by Lizbeth Grimaldo (4476871)

The 5’-nucleotidase S5nA is dispensable for evasion of phagocytosis and biofilm formation in <i>Streptococcus pyogenes</i> by Marcel-Lino Dangel (6281693)

“…Here we show that deletion of the S5nA gene does not significantly affect growth in human blood, evasion of phagocytosis by neutrophils, formation of biofilms and virulence in an infection model with larvae of the greater wax moth <i>Galleria mellonella</i> in <i>S</i>. …”

CD4^SPCD5^hi thymocytes were decreased in either the naturally aged (≥ 18 months old) or the acute atrophied (<i>FoxN1</i> cKO) thymi. by Jiyoung Oh (2010493)

Effects of vidarabine, V2E, V3E and V5E on cardiac fibrosis. by Kenji Suita (750993)

“…<p>We examined the effects of chronic ISO infusion (60 mg/kg/day for 1 week) via osmotic mini-pumps in WT mice with/without vidarabine (Vida), V2E, V3E or V5E on cardiac fibrosis by means of Masson-trichrome staining. …”

Decrease in parasite biomass and IRBC accumulation in organs in infected Rag2^−/− mice. by Carla Claser (185910)

The mechanism on phosphorylation of Hsp20^Ser16 inhibit GA stress and ER stress during OGD/R by Tonglin Lu (6433043)

“…However, ER Stress related protein contents were decreased in the WT and S16D groups compared with the MOCK and S16A groups (P < 0.05). …”

Locomotion and anxiety-like behavior of GIRK2^WT and GIRK2^AgRP-KO mice. by Youjin Oh (3308670)

Cluster analysis of the spatial distribution of heterochromatin and euchromatin after irradiation with 0.5 Gy and 3.5 Gy. by Yang Zhang (30734)

“…We observe a decrease in the ratio of the clustered points 6 h after irradiation for both doses. 24 h after irradiation these changes are reverted. …”

DataSheet_1_High baseline expression of IL-6 and IL-10 decreased CCR7 B cells in individuals with previous SARS-CoV-2 infection during BNT162b2 vaccination.docx by Alberto Ponciano-Gómez (13253028)

Gene expression of 5-HT transporter (5-HTT), 5-HT_1A receptor (5-HT_1AR) and tryptophan hydroxylase-2 (TPH2) in the raphe. by Thibault Renoir (348572)

“…Both 5-HTT and TPH2 mRNA levels were decreased in female WT when compared to male WT. …”

Alternate Wetting and Drying Limits Arsenic in Porewater and Rice Grain under Severe Future Climate Conditions by Aria H. Duncan (22445853)

“…Grain total As concentrations decreased by 1.5× with AWD under a 33 °C climate and by 1.3× under a 38 °C climate. …”

Alternate Wetting and Drying Limits Arsenic in Porewater and Rice Grain under Severe Future Climate Conditions by Aria H. Duncan (22445853)

“…Grain total As concentrations decreased by 1.5× with AWD under a 33 °C climate and by 1.3× under a 38 °C climate. …”

Alternate Wetting and Drying Limits Arsenic in Porewater and Rice Grain under Severe Future Climate Conditions by Aria H. Duncan (22445853)

“…Grain total As concentrations decreased by 1.5× with AWD under a 33 °C climate and by 1.3× under a 38 °C climate. …”

Alternate Wetting and Drying Limits Arsenic in Porewater and Rice Grain under Severe Future Climate Conditions by Aria H. Duncan (22445853)

“…Grain total As concentrations decreased by 1.5× with AWD under a 33 °C climate and by 1.3× under a 38 °C climate. …”

Alternate Wetting and Drying Limits Arsenic in Porewater and Rice Grain under Severe Future Climate Conditions by Aria H. Duncan (22445853)

“…Grain total As concentrations decreased by 1.5× with AWD under a 33 °C climate and by 1.3× under a 38 °C climate. …”