Image_1_Risperidone Mitigates Enhanced Excitatory Neuronal Function and Repetitive Behavior Caused by an ASD-Associated Mutation of SIK1.TIFF by Moataz Badawi (11080101)

“…SIK1-MT protein was distributed in the nucleus and cytoplasm, whereas the distribution of wild-type SIK1 was restricted to the nucleus. We found the disruption of excitatory and inhibitory (E/I) synaptic balance due to an increase in excitatory synaptic transmission and enhancement of neural excitability in the pyramidal neurons in layer 5 of the medial prefrontal cortex in SIK1-MT mice. …”

Image_6_Risperidone Mitigates Enhanced Excitatory Neuronal Function and Repetitive Behavior Caused by an ASD-Associated Mutation of SIK1.TIFF by Moataz Badawi (11080101)

“…SIK1-MT protein was distributed in the nucleus and cytoplasm, whereas the distribution of wild-type SIK1 was restricted to the nucleus. We found the disruption of excitatory and inhibitory (E/I) synaptic balance due to an increase in excitatory synaptic transmission and enhancement of neural excitability in the pyramidal neurons in layer 5 of the medial prefrontal cortex in SIK1-MT mice. …”

Glucose regulates microtubule disassembly and the dose of insulin secretion via tau phosphorylation by Ada Admin (8524211)

“…This remodeling involves disassembly of old microtubules and nucleation of new microtubules. Here, we examine the mechanisms whereby glucose stimulation decreases microtubule lifetimes in β-cells. …”

The 18-kDa Translocator Protein (TSPO) Disrupts Mammary Epithelial Morphogenesis and Promotes Breast Cancer Cell Migration by Xiaoting Wu (445800)

“…In breast cancer cell lines, TSPO silencing or TSPO overexpression significantly altered the migratory activity. In addition, we found that combination treatment with the TSPO ligands (PK 11195 or Ro5-4864) and lonidamine, a clinical phase II drug targeting mitochondria, decreased viability of ER-negative breast cancer cell lines. …”

Supplementary Material for: Association between Ambient Temperature and Risk of Ischaemic Stroke: An Observational Cohort Study by figshare admin karger (2628495)

“…The association was observed within 5 days before stroke onset for LAA but after a longer period for CE. …”

Spatial and temporal dynamics of shifting cultivation in the middle-Amazonas river: Expansion and intensification by Catarina Conte Jakovac (4261894)

“…We found that fallow-period length has decreased from 6.4 to 5.1 years on average, and that expansion over old-growth forest has slowed down over time. …”

Table_1_Transcriptomic and Weighted Gene Co-expression Correlation Network Analysis Reveal Resveratrol Biosynthesis Mechanisms Caused by Bud Sport in Grape Berry.DOCX by Feng Leng (3769381)

“…In particular, we further identified 124 and 19 transcripts that negatively correlated with the contents of trans-resveratrol and cis-resveratrol, respectively, and four transcripts encoding F3'5'H that positively correlated with the contents of trans-resveratrol by weighted gene co-expression network analysis (WGCNA). …”

Alterations in the <em>Aedes aegypti</em> Transcriptome during Infection with West Nile, Dengue and Yellow Fever Viruses by Tonya M. Colpitts (177569)

“…We identified 203 mosquito genes that were ≥5-fold differentially up-regulated (DUR) and 202 genes that were ≥10-fold differentially down-regulated (DDR) during infection with one of the three flaviviruses. …”

DataSheet_1_Lyl1-deficiency promotes inflammatory responses and increases mycobacterial burden in response to Mycobacterium tuberculosis infection in mice.pdf by Shelby-Sara Jones (10794980)

“…Lyl1-deficient mice show reduced survival to Mtb HN878 infection with increased bacterial burden and exacerbated inflammatory responses in chronic stages. We observed that increased susceptibility to infection was accompanied by increased neutrophil recruitment and IL-1, CXCL1, and CXCL5 levels in the lung homogenates. …”

Data_Sheet_1_Identification of Valerate as Carrying Capacity Modulator by Analyzing Lactiplantibacillus plantarum Colonization of Colonic Microbiota in vitro.docx by Julia Isenring (3533741)

“…However, extensive knowledge about host-independent microbe-microbe interactions is lacking. Here, we investigated such colonization process using a derivative of the model probiotic Lactiplantibacillus plantarum WCFS1 into continuously cultivated gut microbiota in the intestinal PolyFermS fermentation model inoculated with five independently immobilized human adult fecal microbiota. …”

Factors associated with mobility of the oldest old by Vanessa Ribeiro dos Santos (4699927)

“…For statistical analysis we used the chi-square test and binary logistic regression to examine the relationship between sociodemographic factors, NCDs and mobility. …”

Glycogen Synthase Kinase (GSK) 3β Phosphorylates and Protects Nuclear Myosin 1c from Proteasome-Mediated Degradation to Activate rDNA Transcription in Early G1 Cells by Aishe A. Sarshad (573525)

“…In G1 this phosphorylation event stabilizes NM1 and prevents NM1 polyubiquitination by the E3 ligase UBR5 and proteasome-mediated degradation. We conclude that GSK3β-mediated phosphorylation of NM1 is required for pol I transcription activation.…”

Quantification of LECs <i>in vivo</i>. by Pier-Anne Lachance (463900)

“…We observed that the percentage of viable CD45+ cells within the viable cell population in the skin of mice was elevated at days 3, and 7 post-CHS compared to non-treated animals (p<0.05). …”

Dynamic demethylation of the <i>IL2RA</i> promoter during <i>in vitro</i> CD4+ T cell activation in association with IL2RA expression by Marie-Pierre Belot (433259)

“…We found that 5/18 CpGs (notably CpG + 3502) show dynamic, active demethylation during the <i>in vitro</i> activation of naive CD4+ T cells. …”

Diel diving behavior of breeding gentoo penguins on King George Island in Antarctica by Won Young Lee (229268)

“…Using a time–depth recorder, we collected diving depths every second from seven gentoo breeders for 5–21 days during the chick-rearing period and analyzed their diving characteristics. …”

Hibernation temperature-dependent <i>Pseudogymnoascus destructans</i> infection intensity in Palearctic bats by Natália Martínková (238012)

“…Contrary to expectation derived from laboratory <i>P. destructans</i> culture experiments, natural infection intensity peaked between 5 and 6°C and decreased at warmer hibernating temperature. …”

Regulation of Cyclin E by transcription factors of the naïve pluripotency network in mouse embryonic stem cells by Fabrice Gonnot (7323194)

“…We observed that mESCs express a low level of miR-15a and that transfection of a miR-15a mimic decreases <i>Cyclin E</i> mRNA level. …”

<i>Sox2</i> Expression Is Regulated by a Negative Feedback Loop in Embryonic Stem Cells That Involves AKT Signaling and FoxO1 by Briana D. Ormsbee Golden (468195)

“…Elevating the expression of these four transcription factors in i-OSKM-ESC does not induce differentiation, but it represses expression of endogenous Sox2. We determined that increases of Sox2 in i-OSKM-ESC lead to increases in activated AKT and inactivation of FoxO1 (an activator of <i>Sox2</i>), as well as decreases in binding of FoxO1 to the 5'flanking region of <i>Sox2</i>. …”

Cerebral FURIN deficiency impairs astrocytic lipophagy through ITGAV maturation by Xiao-Yong Xie (10049552)

“…Accordingly, silencing of <i>Furin</i> in astrocytic cells impairs lipophagic flux with alterations in lipid metabolites. We then demonstrate that cytosolic ITGAV (integrin alpha V) is a principal substrate of FURIN. …”

SI Appendix - Figure Legends.pdf by William Wan (8219789)

“…We show that stiffness and topography impact myocyte molecular and functional properties. …”