Image3_Circulating adipokine concentrations and the risk of venous thromboembolism: A Mendelian randomization and mediation analysis.TIF by Weizhong Xiao (14847373)

“…</p><p>Objective: This study aimed to investigate the causal relationship between circulating adipokine concentrations (including adiponectin, leptin, PAI-1, MCP-1, leptin receptor, and RETN) and the risk of VTE and its subtypes (DVT and PE) and to determine whether circulating adipokine concentrations are a mediator of venous thromboembolic events in obese patients.</p><p>Methods: We used Mendelian randomization (MR) analyses to determine the effects of the body mass index (BMI), adiponectin, leptin, PAI-1, MCP-1, leptin receptor, and RETN levels on VTE, DVT, and PE in a cohort of 11,288 VTE cases, 5,632 DVT cases, 5,130 PE cases, and 254,771 controls. …”

Triptolide Inhibited Cytotoxicity of Differentiated PC12 Cells Induced by Amyloid-Beta_25–35 via the Autophagy Pathway by Pengjuan Xu (314036)

“…In our study investigating the effect and potential mechanism of triptolide on cytotoxicity of differentiated rat pheochromocytoma cell line (the PC12 cell line is often used as a neuronal developmental model) induced by Amyloid-Beta_25–35 (Aβ_25–35), we used 3-(4, 5-dimethylthiazol-2-yl)-2, 5- diphenyltetrazolium bromide (MTT) assay, flow cytometry, Western blot, and acridine orange staining to detect whether triptolide could inhibit Aβ_25–35–induced cell apoptosis. …”

Image12_Circulating adipokine concentrations and the risk of venous thromboembolism: A Mendelian randomization and mediation analysis.JPEG by Weizhong Xiao (14847373)

“…</p><p>Objective: This study aimed to investigate the causal relationship between circulating adipokine concentrations (including adiponectin, leptin, PAI-1, MCP-1, leptin receptor, and RETN) and the risk of VTE and its subtypes (DVT and PE) and to determine whether circulating adipokine concentrations are a mediator of venous thromboembolic events in obese patients.</p><p>Methods: We used Mendelian randomization (MR) analyses to determine the effects of the body mass index (BMI), adiponectin, leptin, PAI-1, MCP-1, leptin receptor, and RETN levels on VTE, DVT, and PE in a cohort of 11,288 VTE cases, 5,632 DVT cases, 5,130 PE cases, and 254,771 controls. …”

Table1_Circulating adipokine concentrations and the risk of venous thromboembolism: A Mendelian randomization and mediation analysis.XLSX by Weizhong Xiao (14847373)

“…</p><p>Objective: This study aimed to investigate the causal relationship between circulating adipokine concentrations (including adiponectin, leptin, PAI-1, MCP-1, leptin receptor, and RETN) and the risk of VTE and its subtypes (DVT and PE) and to determine whether circulating adipokine concentrations are a mediator of venous thromboembolic events in obese patients.</p><p>Methods: We used Mendelian randomization (MR) analyses to determine the effects of the body mass index (BMI), adiponectin, leptin, PAI-1, MCP-1, leptin receptor, and RETN levels on VTE, DVT, and PE in a cohort of 11,288 VTE cases, 5,632 DVT cases, 5,130 PE cases, and 254,771 controls. …”

RNA-Seq Transcriptomic Responses of Full-Thickness Dermal Excision Wounds to <i>Pseudomonas aeruginosa</i> Acute and Biofilm Infection by S. L. Rajasekhar Karna (320813)

“…We studied the wound response: towards acute infection at 2, 6, and 24 hrs after inoculating 10⁶ bacteria into day-3 wounds; and, towards more chronic biofilm infection of wounds similarly infected for 24 hrs but then treated with topical antibiotic to coerce biofilm growth and evaluated at day 5 and 9 post-infection. …”

Table2_Efficacy and Safety of Non-Steroidal Mineralocorticoid Receptor Antagonists in Patients With Chronic Kidney Disease and Type 2 Diabetes: A Systematic Review Incorporating an... by Xinrui Jiang (6076712)

“…Compared with finerenone, esaxerenone showed no significant difference in UACR reduction (WMD 0.24, 95% CI −0.016 to 0.496, p = 0.869); apararenone and esaxerenone showed greater decreases in SBP (WMD 1.37, 95% CI 0.456 to 2.284, p = 0.010; WMD 3.11, 95% CI 0.544 to 5,676, p = 0.021).…”

Supplementary Material for: Duration of Serum Phosphorus Control Associated with Overall Mortality in Patients Undergoing Peritoneal Dialysis by Gong N. (9348857)

“…<b><i>Conclusions:</i></b> In summary, both degree and duration of SP control were tightly associated with overall mortality. We should control SP levels as early, as possible, and as long as we could.…”

The negative effect of lipid challenge on autophagy inhibits T cell responses by Ignacio Guerrero-Ros (6587345)

“…Furthermore, analysis of T cells from diet-induced obese mice confirms that high lipid load inhibits activation-induced responses in T cells. We have found that autophagy is inhibited in CD4⁺ T cells exposed <i>in vitro</i> or <i>in vivo</i> to lipid stress, which causes decreased autophagosome formation and degradation. …”

Image1_Circulating adipokine concentrations and the risk of venous thromboembolism: A Mendelian randomization and mediation analysis.TIF by Weizhong Xiao (14847373)

“…</p><p>Objective: This study aimed to investigate the causal relationship between circulating adipokine concentrations (including adiponectin, leptin, PAI-1, MCP-1, leptin receptor, and RETN) and the risk of VTE and its subtypes (DVT and PE) and to determine whether circulating adipokine concentrations are a mediator of venous thromboembolic events in obese patients.</p><p>Methods: We used Mendelian randomization (MR) analyses to determine the effects of the body mass index (BMI), adiponectin, leptin, PAI-1, MCP-1, leptin receptor, and RETN levels on VTE, DVT, and PE in a cohort of 11,288 VTE cases, 5,632 DVT cases, 5,130 PE cases, and 254,771 controls. …”

Image8_Circulating adipokine concentrations and the risk of venous thromboembolism: A Mendelian randomization and mediation analysis.TIF by Weizhong Xiao (14847373)

“…</p><p>Objective: This study aimed to investigate the causal relationship between circulating adipokine concentrations (including adiponectin, leptin, PAI-1, MCP-1, leptin receptor, and RETN) and the risk of VTE and its subtypes (DVT and PE) and to determine whether circulating adipokine concentrations are a mediator of venous thromboembolic events in obese patients.</p><p>Methods: We used Mendelian randomization (MR) analyses to determine the effects of the body mass index (BMI), adiponectin, leptin, PAI-1, MCP-1, leptin receptor, and RETN levels on VTE, DVT, and PE in a cohort of 11,288 VTE cases, 5,632 DVT cases, 5,130 PE cases, and 254,771 controls. …”

DataSheet_1_Distinct effects of rosuvastatin and rosuvastatin/ezetimibe on senescence markers of CD8+ T cells in patients with type 2 diabetes mellitus: a randomized controlled tri... by Sang-Hyeon Ju (15373114)

“…</p>Results<p>The fractions of CD8+CD57+ (senescent CD8+ T cells) and CD4+FoxP3+ (T_reg) significantly decreased after intervention in the rosuvastatin/ezetimibe group (−4.5 ± 14.1% and −1.2 ± 2.3%, respectively), while these fractions showed minimal change in the rosuvastatin group (2.8 ± 9.4% and 1.4 ± 1.5%, respectively). …”

Image13_Circulating adipokine concentrations and the risk of venous thromboembolism: A Mendelian randomization and mediation analysis.JPEG by Weizhong Xiao (14847373)

“…</p><p>Objective: This study aimed to investigate the causal relationship between circulating adipokine concentrations (including adiponectin, leptin, PAI-1, MCP-1, leptin receptor, and RETN) and the risk of VTE and its subtypes (DVT and PE) and to determine whether circulating adipokine concentrations are a mediator of venous thromboembolic events in obese patients.</p><p>Methods: We used Mendelian randomization (MR) analyses to determine the effects of the body mass index (BMI), adiponectin, leptin, PAI-1, MCP-1, leptin receptor, and RETN levels on VTE, DVT, and PE in a cohort of 11,288 VTE cases, 5,632 DVT cases, 5,130 PE cases, and 254,771 controls. …”

Functional <i>IL6R</i> 358Ala Allele Impairs Classical IL-6 Receptor Signaling and Influences Risk of Diverse Inflammatory Diseases by Ricardo C. Ferreira (174523)

“…Importantly, reduced expression of membrane-bound IL-6R resulted in impaired IL-6 responsiveness, as measured by decreased phosphorylation of the transcription factors STAT3 and STAT1 following stimulation with IL-6 (<i>P</i>≤5.2×10⁻⁷). …”

Table_1_Sex-Differences and Associations Between Complement Activation and Synovial Vascularization in Patients with Late-Stage Knee Osteoarthritis.docx by Emily U. Sodhi (12610462)

“…</p>Conclusion<p>Higher synovial fluid C5 levels were associated with increased complement activation and decreased synovial vascularization in males but not in females with OA. …”

Transcription factor c-Jun activation and cell viability in SH-SY5Y cell line following stimulation with H₂O₂ for 3 h. by Marco Feligioni (287395)

“…Application of D-JNKI1, 30 min prior to H₂O₂ stimulation decreased P-c-Jun activation. Densitometric analysis revealed a fold increase ∼1.60 for 50 and ∼1.80 for 75 mM of P-c-Jun/c-Jun ratio in cells stimulated with H₂O₂ compared to control cells. …”

Expression of CSPGs in the high-dose ChABC treatment groups at 4 weeks after spinal cord transection. by Chu-Hsun Cheng (798713)

“…There was an abundance of CS56 immunoreactivity within the lesion site in the transected spinal cord (A). In contrast, the ChABC treatment dramatically decreased the CS56 immunoreactivity in the 50 U (E) and 100 U (I) groups. …”

AMPK, LKB1, p53, p21, and p16 protein expression after H₂O₂ exposure for 1 and 16 hr. by Yasuo Ido (172159)

“…Phosphorylation of LKB1 (Ser431), an upstream kinase of AMPK, was slightly decreased by 50 µM H₂O₂ and increased by 250 µM H₂O₂ (<b>d, e</b>). p53 expression and phosphorylation were increased by 50 and 100 µM H₂O₂ and were variably affected by 250 µM H₂O₂ (<b>f</b>). …”

The β2AR Pathway Involves PI3K/AKT in Controlling Keratinocyte Migration by Raja K Sivamani (587219)

“…A representative western blot (of two different human keratinocyte strains) is shown. …”

Potential of hydrogen (pH) differentially modulates cadmium stress response in abscisic acid-deficient sitiens tomato mutant by Georgia Bertoni Pompeu (7141529)

“…Moreover, sit shoot grown at pH 5 showed decreased activities of superoxide dismutase (SOD), Mn-SOD II and Cu/Zn-SOD V, in 0 and 50 ?…”

Contribution of JNK isoforms to TNF-α-induced IL-8 expression. by Shinichi Namba (3350288)

“…<p>(A) Expression of phosphorylated JNK1/2 (p-JNK1/2) and total JNK1/2 (t-JNK1/2) was detected by western blotting in cells treated with TNF-α (50 ng/mL) for 0–120 min (upper panel). …”