DataSheet_1_microRNA-144/451 decreases dendritic cell bioactivity via targeting interferon-regulatory factor 5 to limit DSS-induced colitis.pdf by Zhijie Lin (173992)

“…Mechanistically, the miR-144 directly targets the 3`-UTR of IRF5 and represses the expression of IRF5 in DCs. …”

50% Reduction of dynein perturbs the movement of APP vesicles. by Gary J. Iacobucci (192833)

“…<p>(<b>A</b>) A representative movie montages from a single neuron is shown from a primary neuronal culture expressing APP-YFP in the context of 100% dynein (APP-YFP) or 50% dynein (APP-YFP; robl^K −/+). …”

Two conformationally distinct α-synuclein oligomers share common epitopes and the ability to impair long-term potentiation - Fig 5 by Femke van Diggelen (6499112)

CHIKV-CZC-LAMP detected <50 PFU CHIKV. by Kyoko Hayashida (281242)

Lipid consumption of epimastigotes supplemented with 10 or 50% FCS. by Miria G. Pereira (212119)

“…Note that in both initial culture conditions, the fluorescence decreases along time in parasites from 10% FCS or 50% FCS. …”

Image_3_Tocilizumab (TCZ) Decreases Angiogenesis in Rheumatoid Arthritis Through Its Regulatory Effect on miR-146a-5p and EMMPRIN/CD147.jpeg by Devy Zisman (11838428)

“…In vitro, the accumulation in the supernatants of the pro-angiogenic factors EMMPRIN, VEGF and MMP-9 was increased by co-culturing the HT1080 fibroblasts and the U937 monocytes, while the accumulation of the anti-angiogenic factor thrombospondin-1 (Tsp-1) and the expression levels of miR-146a-5p were reduced. Transfection of HT1080 cells with the miR-146a-5p mimic, decreased the accumulation of EMMPRIN, VEGF and MMP-9. …”

Image_4_Tocilizumab (TCZ) Decreases Angiogenesis in Rheumatoid Arthritis Through Its Regulatory Effect on miR-146a-5p and EMMPRIN/CD147.jpeg by Devy Zisman (11838428)

“…In vitro, the accumulation in the supernatants of the pro-angiogenic factors EMMPRIN, VEGF and MMP-9 was increased by co-culturing the HT1080 fibroblasts and the U937 monocytes, while the accumulation of the anti-angiogenic factor thrombospondin-1 (Tsp-1) and the expression levels of miR-146a-5p were reduced. Transfection of HT1080 cells with the miR-146a-5p mimic, decreased the accumulation of EMMPRIN, VEGF and MMP-9. …”

Image_2_Tocilizumab (TCZ) Decreases Angiogenesis in Rheumatoid Arthritis Through Its Regulatory Effect on miR-146a-5p and EMMPRIN/CD147.jpeg by Devy Zisman (11838428)

“…In vitro, the accumulation in the supernatants of the pro-angiogenic factors EMMPRIN, VEGF and MMP-9 was increased by co-culturing the HT1080 fibroblasts and the U937 monocytes, while the accumulation of the anti-angiogenic factor thrombospondin-1 (Tsp-1) and the expression levels of miR-146a-5p were reduced. Transfection of HT1080 cells with the miR-146a-5p mimic, decreased the accumulation of EMMPRIN, VEGF and MMP-9. …”

Image_1_Tocilizumab (TCZ) Decreases Angiogenesis in Rheumatoid Arthritis Through Its Regulatory Effect on miR-146a-5p and EMMPRIN/CD147.jpeg by Devy Zisman (11838428)

“…In vitro, the accumulation in the supernatants of the pro-angiogenic factors EMMPRIN, VEGF and MMP-9 was increased by co-culturing the HT1080 fibroblasts and the U937 monocytes, while the accumulation of the anti-angiogenic factor thrombospondin-1 (Tsp-1) and the expression levels of miR-146a-5p were reduced. Transfection of HT1080 cells with the miR-146a-5p mimic, decreased the accumulation of EMMPRIN, VEGF and MMP-9. …”

Data Sheet 1_Probiotic Limosilactobacillus reuteri KUB-AC5 decreases urothelial cell invasion and enhances macrophage killing of uropathogenic Escherichia coli in vitro study.pdf by Arishabhas Tantibhadrasapa (13929639)

“…However, the antibacterial and immune modulatory effects of AC5 on UPEC have never been explored.</p>Methods<p>Here, we investigated both the direct and indirect effects of AC5 against UPEC isolates (UTI89, CFT073, and clinical MDR UPEC AT31) in vitro. …”

The presence of B cells promotes cellular expansion and CD4⁺ T cell proliferation in the lung of mice with chronic TB. by Yong Chen (109188)

RNA sequencing linkage analysis identifies a single base pair change on Chromosome 25 that is tightly linked to the <i>escapist</i> hypersensitive phenotype. by Elelbin A. Ortiz (8655285)

Table_1_Preclinical characterization of amubarvimab and romlusevimab, a pair of non-competing neutralizing monoclonal antibody cocktail, against SARS-CoV-2.docx by Yun Ji (464484)

“…However, the continuous virus evolution requires diverse mAb options to combat variants. Here we describe two fully human mAbs, amubarvimab (BRII-196) and romlusevimab (BRII-198) that bind to non-competing epitopes on the receptor binding domain (RBD) of spike protein and effectively neutralize SARS-CoV-2 variants. …”

The inactivation of <i>Kdm6a</i> in mice had age- and gender-dependent effects on normal hematopoiesis. by Ling Tian (107492)

“…Aged KO-F mice developed a mild macrocytic anemia, which was characterized by decreased hemoglobin (Hb: 11.5 g/dL in KO-F mice vs. 14.28 g/dL in WT-F mice, p = 0.0137) with an increased mean corpuscular volume (MCV: 51 fL in KO-F mice vs. 40.55 fL in WT-F mice, p = 0.0001) and mean corpuscular hemoglobin (MCH: 15.15 pg in KO-F mice vs. 12.85 pg in WT-F mice, p = 0.0004). …”

Table_5_NOTCH1 mutation associates with impaired immune response and decreased relapse-free survival in patients with resected T1-2N0 laryngeal cancer.docx by Xiao-yang Gong (13103400)

“…A total of 469 genomic alterations were detected in 211 distinct cancer-relevant genes, and the genes found to be mutated in more than five patients (>10%) included tumor protein p53 (TP53, 78.5%), FAT atypical cadherin 1 (FAT1, 26%), LDL receptor related protein 1B (LRP1B, 19%), cyclin dependent kinase inhibitor 2A (CDKN2A, 17%), tet methylcytosine dioxygenase 2 (TET2, 17%), notch receptor 1 (NOTCH1, 12%) and neuregulin 1 (NRG1, 12%). …”

Chromosomal Translocations in the Parasite <i>Leishmania</i> by a MRE11/RAD50-Independent Microhomology-Mediated End Joining Mechanism by Marie-Claude N. Laffitte (669627)

“…Sequencing data also showed a decreased coverage at subtelomeric locations in many chromosomes in the <i>MRE11</i>^<i>-/-</i><i>RAD50</i>^<i>-/-</i> parasites. …”

Tyro 3 overexpression decreases the production of Aβ from 293APPswe cells and Gas6 inhibits the effect in a concentration-dependent manner. by Yan Zheng (61178)

“…(D) ELISA assay shows that a decrease in Aβ in Tyro-3-transfected 293APPswe cells relative to the GFP transfected controls. …”

Characteristics of patients with AKI diagnosed using eKDIGO only by the decrease in sCr (deKDIGO) and no AKI. by Marina Wainstein (12437091)

Pictorial view of some highly poisonous plants based on their LD50 values and respondent scores. by Faisal Rasool (12530732)

DA receptor agonist pramipexole reduces generosity reference-point (V). by Sergio Oroz Artigas (8207559)