200 WT nts but not WT UTRs at each terminus are sufficient for efficient recovery of replicating virus. by Debarpan Dhar (724473)

Discovery of New Inhibitors of Hepatitis C Virus NS3/4A Protease and Its D168A Mutant by Ittipat Meewan (7455041)

“…Several drugs targeting the protease have been developed, but drug-resistant mutant strains emerged. Here, we screened a library and synthesized a novel class of small molecules based on a tryptophan derivative scaffold identified as HCV NS3/4A protease inhibitors that are active against both wild type and mutant form of the protease. …”

Cost-effectiveness and budget impact of immediate antiretroviral therapy initiation for treatment of HIV infection in Côte d’Ivoire: A model-based analysis by Eric N. Ouattara (6890174)

“…Outcomes from the model included life expectancy, 10-year medical resource use, incremental cost-effectiveness ratios (ICERs) in $/year of life saved (YLS), and 5-year budget impact. We simulated people with HIV (PWH) in care (mean CD4: 259/<i>μ</i>L, SD 198/<i>μ</i>L) and transmitted cases. …”

Revisiting the sealed heating method–heating cells in a low volume decreases nuclear Chk1. by Andrew J. Massey (239469)

SDG decreases iron-induced oxidative stress in H9c2 cells. by Stephanie Puukila (568109)

EC50 and percentage decrease in intracellular <i>Listeria</i> viability for effective compounds. by Marie-Eve Charbonneau (5658799)

TIP47 is involved in HCV RNA replication <i>via</i> interaction with NS5A. by Dorothee A. Vogt (247917)

“…Values are expressed as fold increase of luciferase (RLU) per well, over a 4 h time point (mean ± standard deviation; n = 3, *P<0.05, **P<0.01, ***P<0.001). The decrease of A₉-I₁₂ and W₉-I₁₂ is significant in relation to WT (indicated in grey *), whereas the increase in A₉-V₁₂ is significant in relation to A₉-I₁₂ where indicated (indicated in black *). …”

AAV-mediated Atp6v1c1 knockdown decreased TRAP positive cells and Atp6v1c1 expression in the periodontitis lesion area. by Sheng Li (107261)

Rap1A knockdown <i>in vitro</i> impairs steady state monolayer integrity and decreases transepithelial electrical resistance. by Erika S. Wittchen (256700)

Variable importance plot (mean decrease accuracy and mean decrease Gini). by Fernando Martinez-Taboada (8655132)

Decreased echinocandin susceptibility in <i>Candida parapsilosis</i> causing candidemia and emergence of a pan-echinocandin resistant case in China by Yating Ning (11264310)

Multi-way sensitivity analysis on transmission rate, CD4 count at diagnosis, and ART costs in a model-based analysis of Immediate ART initiation in Côte d’Ivoire. by Eric N. Ouattara (6890174)

Expression of AC5 and AC6 in WT and AMPKα2-/- mice. by Anne Garnier (130125)

Subjects:

Olaparib reverses the oxLDL-mediated decrease in co-immunoprecipitation of IκBα with RelA or p50. by Khamis Mustafa (17941332)

“…Relative band densities from three independent experiments were analyzed. (A) OxLDL decreased co-immunoprecipitation of IκBα with both RelA and p50, and olaparib reversed the effect of oxLDL on the dissociation of IκBα with RelA and p50. …”

Pretreatment with SDG prevents iron induced decrease in H9c2 cell size. by Stephanie Puukila (568109)

SDG decreases iron-induced MMP gene expression in H9c2 cells. by Stephanie Puukila (568109)

Stat1 prevents the decrease of p27^Kip1 by activated Ras. by Shuo Wang (143908)

Decreased proliferation and increased apoptosis in <i>Mab21l2</i> mutant embryos. by Yohei Saito (180130)

“…Scale bars represent 100 µm (A, D, H, K) and 50 µm (N and P). (R) Quantitative RT-PCR for genes regulating cell proliferation and apoptosis (<i>N-myc</i>, <i>Id2</i>, <i>Cyclin D1</i>, <i>Cyclin D2</i>), marker genes of myocardial differentiation (<i>Anf</i>, <i>Chisel</i>, <i>Mlc2v</i>), genes essential for the development of the trabecular myocardium (<i>Erbb2</i>, <i>Erbb4</i>, <i>Bmp10</i>), genes essential for heart development (<i>Nkx2.5</i>, <i>Gata4</i>), and endocardial transcripts (<i>Flk1</i>, <i>Tie1</i>, <i>Tie2</i>) normalized to <i>Gapdh</i> expression using RNA from dissected hearts of E11.5 WT and <i>Mab21l2</i> mutant (−/−) embryos. …”

Decreasing fluconazole susceptibility of clinical South African <i>Cryptococcus neoformans</i> isolates over a decade by Serisha D. Naicker (8648370)

Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

Subjects: