The promise of tirzepatide: A narrative review of metabolic benefits by Sara Sokary (17337724)

“…Moreover, tirzepatide exhibited favorable effects on glycemic control, with notable reductions in HbA1c levels ranging from 20.4 mmol/mol with the 5 mg dose to 28.2 mmol/mol with the 15 mg dose, following treatment durations lasting 40–52 weeks. …”

Shear Behavior of One-Way Reinforced Concrete Hollow Slabs Voided with PET Void Formers by Hasan, Haider H.

Get full text

The Impacts of COVID-19 on the Well-Being of students with SEN in Primary Stage in Dubai Schools by ABUSNENEH, NOOR

“…The current paper aimed to verify the impact of the Covid-19 pandemic on the well-being of a sample of (74) students who were classified by teachers as a student with Special Educational Needs in five of Dubai primary schools. …”
Get full text

Tolfenamic Acid Derivatives: A New Class of Transcriptional Modulators with Potential Therapeutic Applications for Alzheimer’s Disease and Related Disorders by Jaunetta Hill (18255631)

“…Previously, we have shown in AD animal models that tolfenamic acid (TA) can lower the expression of AD-related genes and their products and subsequently reduce pathological burden and improve cognition. Using TA as a scaffold and the zinc finger domain of SP1 as a pharmacophore, we developed safer and more potent brain-penetrating analogs that interfere with sequence-specific DNA binding at transcription start sites and predominantly modulate the expression of SP1 target genes. …”

Methylation at global LINE-1 repeats in human blood are affected by gender but not by age or natural hormone cycles by El Maarri, Osman

“…In contrast, a decrease in methylation was observed in estrogen-treated T47-Kbluc cell lines strongly expressing estrogen receptor. …”
Get full text
Get full text
Get full text
Get full text

Quantile dependencies and connectedness between the gold and cryptocurrency markets: effects of the COVID-19 crisis by Mensi, Walid

“…In contrast, the degree of dependence decreases at the intermediate- and long-terms during COVID-19 period than before. …”
Get full text
Get full text
Get full text
Get full text

Glycemic outcomes of Advanced Hybrid Closed Loop system in children and adolescents with Type 1 Diabetes, previously treated with Multiple Daily Injections (MiniMed 780G system in... by Goran Petrovski (129836)

“…HbA1c decreased from 8.6 ± 1.7% (70 ± 18.6 mmol/mol) at baseline, to 6.5 ± 0.7% (48 ± 7.7 mmol/mol) at the end of the study (<i>p</i> = 0.001). …”

Exploring Sustainable Strategies for Shelter Design at Refugee Camps: The Case of Domiz 1 Refugee Camp in Iraq by AL AMEEN, FARAH

“…Furthermore, a 42% decrease in cooling loads, and 31% decrease in heating loads was achieved by using the proposed wall panel, the sunspace during winter, and the roof canopy during winter, in comparison to the baseline case, the UNHCR tent.…”
Get full text

DLC2/StarD13 plays a role of a tumor suppressor in astrocytoma by El-Sitt, Sally

“…Knocking down StarD13 using siRNA led to a decrease in cell death and an increase in cell viability, proving that StarD13 is indeed a tumor suppressor in astrocytomas. …”
Get full text
Get full text
Get full text

Unraveling the impaired incretin effect in obesity and type 2 diabetes: Key role of hyperglycemia-induced unscheduled glycolysis and glycolytic overload by Naila Rabbani (291722)

“…<p>Glucagon-like peptide-1 (GLP-1) agonists and GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) co-agonists are major treatment options for subjects with obesity and patients with type 2 diabetes mellitus (T2DM). …”

mTORC1 loss impairs epidermal adhesion via TGF-b/Rho kinase activation by Georgess, Dan

“…In mice with conditional epidermal loss of the mTORC1 components Rheb or Rptor, mTORC1 loss of function unexpectedly resulted in a profound skin barrier defect with epidermal abrasions, blistering, and early postnatal lethality, due to a thinned epidermis with decreased desmosomal protein expression and incomplete biochemical differentiation. …”
Get full text
Get full text
Get full text
Get full text

RHOG activates RAC1 through CDC42 leading to tube formation in vascular endothelial cells by El Atat, Oula

“…While knocking down either RHO, GTPase did not affect p-AKT levels, and p-ERK decreased in response to the knocking down of RHOG, CDC42 or RAC1. …”
Get full text
Get full text
Get full text
Get full text

Trends in criminal convictions in Japan for vehicle collisions where one driver suffers from an epileptic seizure by Mineko Baba (19774386)

“…We used LEX/DB that is a database of the precedent after 1875 in Japan, too. …”

Type 2 Diabetes Coagulopathy Proteins May Conflict With Biomarkers Reflective of COVID-19 Severity by Abu Saleh Md Moin (6189512)

“…A hyperinsulinemic clamp was performed and normoglycemia induced in T2D [4.5 ± 0.07 mmol/L (81 ± 1.2 mg/dl)] for 1-h, following which blood glucose was decreased to ≤2.0 mmol/L (36 mg/dl). …”

Total Quality Implementation on Marine Transportation Association Under Natural Disruption of COVID-19 Pandemic by ASAD, NUHA JAMAL

“…Social distancing, i.e., decreasing collaborations between people to dial back the spread of the infection, has turned into the new standard. …”
Get full text

1,2,4-Trimethylbenzene Transformation Reaction Compared With Its Transalkylation Reaction With Toluene Over USY Zeolite by Al-Khattaf, H

“…1,2,4-Trimethylbenzene (TMB) transalkylation with toluene has been studied over USY zeolite type catalyst using a riser simulator that mimics the operation of a fluidized-bed reactor. …”
Get full text

In vitro ischemia suppresses hypoxic induction of hypoxia-inducible factor-1α by inhibition of synthesis and not enhanced degradation by Sleiman, Sama F.

“…We observed ATP depletion under OGD vs. hypoxia and propose that ATP depletion enhances translational suppression, overcoming the selective synthesis of HIF concurrent with global decreases in protein synthesis in hypoxia. Taken together, these findings biochemically characterize a practical reporter for monitoring HIF-1α levels and support a novel model for HIF regulation in an in vitro model of human ischemia.…”
Get full text
Get full text
Get full text

Cytotoxicity of [HuArgI (co)-PEG5000]-induced arginine deprivation to ovarian Cancer cells is autophagy dependent by Nasreddine, Ghenwa

“…Ovarian cancer cell lines were negative for annexinV staining while showing loss of membrane integrity and absence of caspase activation, indicating caspase-independent, non-apoptotic cell death. [HuArgI (Co)-PEG5000]-induced arginine deprivation led to extensive and prolonged activation of autophagy, which proved to be deleterious to cell survival since its inhibition led to a significant decrease in cytotoxicity. …”
Get full text
Get full text
Get full text
Get full text

Forecast of the outbreak of COVID-19 using artificial neural network: Case study Qatar, Spain, and Italy by Moayyad Shawaqfah (17280637)

“…The verified and validated growth model of COVID-19 for these countries showed the effects of the measures taken by the government and medical sectors to alleviate the pandemic effect and the effort to decrease the spread of the virus in order to reduce the death rate. …”

Epstein–Barr Virus Epidemiology, Serology, and Genetic Variability of LMP-1 Oncogene Among Healthy Population: An Update by Maria K. Smatti (4675852)

“…Here, we provide a review of the EBV epidemiology and the genetic variability of the oncogene LMP-1. …”