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Protein arginine methyltransferase 5 (PRMT5) promotes survival of lymphoma cells via activation of WNT/B-catenin and AKT/GSK3B proliferative signaling
Published 2019“…In this report, we investigate the relationship between PRMT5 and WNT/B- CATENIN as well as AKT/GSK3B proliferative signaling in three different types of non-Hodgkin's lymphoma cell lines, clinical samples, and mouse primary lymphoma cells. …”
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PRMT5-PTEN molecular pathway regulates senescence and self-renewal of primary glioblastoma neurosphere cells
Published 2017“…Previously, we have shown that silencing of PRMT5 expression in differentiated GBM cell lines results in apoptosis and reduced tumour growth in mice. …”
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Wind energy potential along the onshore and offshore Qatar
Published 2020“…Wind energy is one among the clean and renewable energy resources. The utilization of non-conventional energies over the conventional sources helps to reduce the carbon emissions significantly. …”
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Changes in expression of Kv7.5 and Kv7.2 channels in dorsal root ganglion neurons in the streptozotocin rat model of painful diabetic neuropathy
Published 2020“…We found 35 days post-STZ: (1) a significant decrease in Kv7.5-immunoreactivity in small (<30 μm) DRG neurons (both IB4 positive and IB4 negative) and medium-sized (30−40 μm) neurons, and (2) a significant increase in Kv7.2-immunoreactivity in small (<30 μm) neurons, and a non-significant increase in medium/large neurons. …”
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The maxima in northerly wind speeds and wave heights over the Arabian Sea, the Arabian/Persian Gulf and the Red Sea derived from 40 years of ERA5 data
Published 2020“…Recent studies point out the importance of northerly winds and waves in the Arabian Sea, especially those due to shamal and makran events in addition to the northeast monsoon system. We have analyzed climatology and trends of northerly maximum wind speed and significant wave height (Hs) in the Arabian Sea and the connected marginal seas, Arabian/Persian Gulf and the Red Sea, during non-monsoon season derived from 40 years of ERA5 wind and wave data, and estimated monthly, annual and decadal extreme climate and their trends. …”
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A BRET-based Mpro biosensor containing a nanobody and tandem cleavage sites shows an increased cleavage rate
Published 2025“…Here, we report the engineering of a Bioluminescence Resonance Energy Transfer (BRET)-based SARS-CoV-2 main protease (Mpro) biosensor containing the Mpro N-terminal autocleavage sequence in tandem and a nanobody that shows an enhanced rate of Mpro-mediated proteolytic cleavage. …”
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Global, regional, and national burden of household air pollution, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021
Published 2025“…Using a systematic review of the epidemiological literature and a newly developed meta-regression tool (meta-regression: Bayesian, regularised, trimmed), we derived disease-specific, non-parametric exposure–response curves to estimate relative risk as a function of PM2·5 concentration. …”
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Kv7 Channel Activators Flupirtine and ML213 Alleviate Neuropathic Pain Behavior in the Streptozotocin Rat Model of Diabetic Neuropathy
Published 2024“…Indeed, using the streptozotocin (STZ) rat model of DPNP, we have previously shown that Kv 7 activation with their non-selective activator retigabine attenuated neuropathic pain behavior suggesting that these channels are implicated in DPNP pathogenesis. …”
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Repositioning of the global epicentre of non-optimal cholesterol
Published 2020“…These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health4,5. …”
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Investigation Into the Effects of Non-Linear Loading of Domestic Power Network on Home Appliances
Published 2016“…The motor is rated for 110V rms, 1500 rpm and 0.5 HP. The reference of the converter is generated by adding 3rd and 5th harmonic component to the fundamental component. …”
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Burden and trend of diet-related non-communicable diseases in Australia and comparison with 34 OECD countries, 1990-2015: findings from the Global Burden of Disease Study 2015.
Published 2018“…Diet is a major determining factor for many non-communicable chronic diseases (NCDs). However, evidence on diet-related NCD burden remains limited. …”
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Novel, selective EPO receptor ligands lacking erythropoietic activity reduce infarct size in acute myocardial infarction in rats
Published 2016“…In study 4, AF43136 at 10 mg/kg decreased infarct size, similarly to the positive control CsA compared to the appropriate vehicle (39.4 ± 5.9% vs. 58.1 ± 5.4% and 45.9 ± 2.4% vs. 63.8 ± 4.1%, p < 0.05, respectively). …”
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Unveiling into Genetic Architecture of Transgenerational Stress Memory via Promoting Drought Tolerance in Barley
Published 2024“…During the seed germination test, it was observed that all genotypes exhibited a decrease in both germination percentage (G%) and germination pace (GP) when comparing seeds from Non-Stressed Plants (NP) to seeds from Stressed Plants (SP). …”
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