Stimulation of sphingosine 1-phosphate signaling as an alveolar cell survival strategy in emphysema by Diab, Khalil J.

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The effects of long-term testosterone treatment on endocrine parameters in hypogonadal men: 12-year data from a prospective controlled registry study by Aksam Yassin (14779204)

“…We observed an increase in TT of 15.5 nmol/L (<i>p</i> < 0.0001), a reduction in SHBG of 10.5 nmol/L (<i>p</i> < 0.0001) and an increase in calculated free T of 383.04 pmol/L (<i>p</i> < 0.0001) over the study period. …”

Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants by Bin, Zhou

“…Global age-standardised prevalence of raised blood pressure was 24·1% (21·4–27·1) in men and 20·1% (17·8–22·5) in women in 2015. …”
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NMR Study of the Interaction of Trinitrobenzene with High-Spin Tetraarylporphinato-Iron(II1) Halides by Kabbani, Ahmad T.

“…The averaged TNB shifts and line-widths are indicative of 1:1 complexes whose stability is decreased by more electron-withdrawing axial halides or phenyl substituents, consistent with the porphyrin acting as a π donor in the adduct. …”
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Combined Noncoding RNA-mRNA Regulomics Signature in Reprogramming and Pluripotency in iPSCs by Salam Salloum-Asfar (656363)

“…Decreased levels of let-7a-5p showed an increase of SP8 as described previously. …”

Measuring routine childhood vaccination coverage in 204 countries and territories, 1980–2019: a systematic analysis for the Global Burden of Disease Study 2020, Release 1 by Natalie C Galles (9715361)

“…</p><p><br></p><h3>Findings</h3><p dir="ltr">By 2019, global coverage of third-dose DTP (DTP3; 81·6% [95% uncertainty interval 80·4–82·7]) more than doubled from levels estimated in 1980 (39·9% [37·5–42·1]), as did global coverage of the first-dose measles-containing vaccine (MCV1; from 38·5% [35·4–41·3] in 1980 to 83·6% [82·3–84·8] in 2019). …”

Long non-coding RNA MALAT1 promotes steatosis in HepG2 cells by modulating target gene expression in presence of Exendin-4 by Olfa Khalifa (10914452)

Glycemic outcomes of Advanced Hybrid Closed Loop system in children and adolescents with Type 1 Diabetes, previously treated with Multiple Daily Injections (MiniMed 780G system in... by Goran Petrovski (129836)

“…HbA1c decreased from 8.6 ± 1.7% (70 ± 18.6 mmol/mol) at baseline, to 6.5 ± 0.7% (48 ± 7.7 mmol/mol) at the end of the study (<i>p</i> = 0.001). …”

The promise of tirzepatide: A narrative review of metabolic benefits by Sara Sokary (17337724)

“…Moreover, tirzepatide exhibited favorable effects on glycemic control, with notable reductions in HbA1c levels ranging from 20.4 mmol/mol with the 5 mg dose to 28.2 mmol/mol with the 15 mg dose, following treatment durations lasting 40–52 weeks. …”

1,2,4-Trimethylbenzene Transformation Reaction Compared With Its Transalkylation Reaction With Toluene Over USY Zeolite by Al-Khattaf, H

“…1,2,4-Trimethylbenzene (TMB) transalkylation with toluene has been studied over USY zeolite type catalyst using a riser simulator that mimics the operation of a fluidized-bed reactor. …”
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Trends in criminal convictions in Japan for vehicle collisions where one driver suffers from an epileptic seizure by Mineko Baba (19774386)

“…<p dir="ltr">For the last fourteen years in Japan, casualties due to traffic collisions have decreased. There were 9,073 traffic fatalities in 2000 and 4,113 in 2014. …”

Deciphering the In vitro Role of microRNAs miR-21-3p and miR-222-5p In the Regulation of Clostridioides difficile Flagellin-Induced Inflammation by Salman, Zeina

“…Functional assays revealed that miR-222-5p overexpression led to a significant increased expression of key pro-inflammatory cytokines, including IL-8 and TNF-α, while knockdown of these miRNAs resulted in their decreased expression. …”
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In vitro ischemia suppresses hypoxic induction of hypoxia-inducible factor-1α by inhibition of synthesis and not enhanced degradation by Sleiman, Sama F.

“…This study investigated the mechanism by which in vitro ischemia (oxygen-glucose deprivation; OGD) affects canonical hypoxic HIF-1α stabilization. We validated the use of a reporter containing the oxygen-dependent degradation domain of HIF-1α fused to firefly luciferase (ODD-luc) to monitor quantitatively distinct biochemical events leading to hypoxic HIF-1α expression or stabilization in a human neuroblastoma cell line (SH-SY5Y). …”
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PD-L1 Expression in Human Breast Cancer Stem Cells Is Epigenetically Regulated through Posttranslational Histone Modifications by Pramod Darvin (153341)

“…The active demethylation of PD-L1 promoter was confirmed by the increase in the distribution of 5hmC and decrease in 5mC levels and the upregulation of TET3 and downregulation of DNMTs enzymes in MCF-7 tumorspheres, compared with the cell line. …”

Assessment of tropospheric NO₂ concentrations over greater Doha using Sentinel-5 TROPOspheric monitoring instrument (TROPOMI) satellite data: Temporal analysis, 2018–202... by Yasir E. Mohieldeen (22155901)

Cytotoxicity of [HuArgI (co)-PEG5000]-induced arginine deprivation to ovarian Cancer cells is autophagy dependent by Nasreddine, Ghenwa

“…[HuArgI (Co)-PEG5000]-induced arginine deprivation led to extensive and prolonged activation of autophagy, which proved to be deleterious to cell survival since its inhibition led to a significant decrease in cytotoxicity. …”
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Screening for antiretroviral drug resistance among treatment-naive human immunodeficiency virus type 1-infected individuals in Lebanon by Mokhbat, Jacques M.

“…Introduction: Antiretroviral therapy (ART) has been successful at decreasing the morbidity and mortality associated with human immunodeficiency virus type 1 (HIV-1) infection. …”
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Targeting arginine auxotrophy in pancreatic cancer cells using human recombinant arginase I-induced arginine deprivation. (c2017) by Khalil, Nathalie

“…This absence of caspase activation was confirmed by a 72 hours cytotoxicity assay on Panc-1 cells, which revealed the failure of the pan-caspase inhibitor, Z-VAD, to reverse or decrease arginine depletion-triggered cell death. …”
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Long-Haul Northeast Travel Disrupts Sleep and Induces Perceived Fatigue in Endurance Athletes by Christopher J. Stevens (3391547)

“…</p><p dir="ltr"><br></p><h3>Results: </h3><p dir="ltr">All comparisons are to baseline. There was a most likely decrease in sleep duration on the over-night flight (-4.8 ± 1.2 h; effect size; ±90% confidence limits = 3.06; ±1.26) and a very likely increase in sleep duration on the first night after arrival (0.7 ± 1.0 h; 1.15; ±0.92). …”

Inhibiting HSP90 changes the expression pattern of PINK1 and BNIP3 and induces oxidative stress in colon cancer cells by Ejlal Abu-El-Rub (5168183)

“…Similarly, genetic knockdown of HSP90 in RKO cells produced comparable effects, including reduced cell survival and a decreased PINK1/BNIP3 ratio.</p><h3>Conclusion</h3><p dir="ltr">Targeting HSP90 in colon cancer cells disrupts their survival by decreasing PINK1 and increasing BNIP3, which activates oxidative and endoplasmic reticulum stress, ultimately triggering apoptosis.…”