Protein arginine methyltransferase 5 (PRMT5) promotes survival of lymphoma cells via activation of WNT/B-catenin and AKT/GSK3B proliferative signaling by Chung, Jihyun

“…We show that PRMT5 stimulates WNT/B-CATENIN signaling through direct epigenetic silencing of pathway antagonists, AXIN2 and WIF1, and indirect activation of AKT/GSK3 signaling.PRMT5 inhibition with either shRNA-mediated knockdown or a specific small molecule PRMT5 inhibitor, CMP-5, not only leads to derepression of WNT antagonists and decreased levels of active phospho-AKT (Thr-450 and Ser-473) and inactive phospho- GSK3B (Ser-9) but also results in decreased transcription of WNT/B-CATENIN target genes, CYCLIN D1, c-MYC, and SURVIVIN, and enhanced lymphoma cell death. …”
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Serum Vitamin D Concentration ≥75 nmol/L Is Related to Decreased Cardiometabolic and Inflammatory Biomarkers, Metabolic Syndrome, and Diabetes; and Increased Cardiorespiratory Fitn... by Ganji, Vijay

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Decreased number of acute appendicitis cases in pediatric population during the COVID-19 pandemic: Any link? by Zvizdic, Zlatan

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Rare case of norethisterone-induced hepatitis: A case report. by Arafa, Eiman A

“…We report a case of probable norethisterone-related liver injury, manifesting as a significant rise in liver transaminases in a 62-year-old woman. …”
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Nitric Oxide Releasing Hydrogel Nanoparticles Decreases Epithelial Cell Injuries Associated With Airway Reopening. by Shurbaji, Samar

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Prevalence and Phylogenetic Analysis of Parvovirus (B19V) among Blood Donors with Different Nationalities Residing in Qatar by Abdelrahman, Doua

“…Human parvovirus (B19V) is the causative agent of erythema infectiosum in children and is linked to a wide range of clinical manifestations. …”
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Turning point in COVID-19 severity and fatality during the pandemic: a national cohort study in Qatar by Chemaitelly, Hiam

“…Among all severe, critical and fatal cases, 99.5% occurred during the primary infection. …”
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A case of probable esomeprazole-induced transient liver injury in a pregnant woman with hyperemesis by B. , Thomas

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Understanding the False Positive of Modified Martensitic Steels in Sweet & Sour Service Conditions Using a Point Defect Model Perspective by Martinez, Alan

“…These results indicate a critical point in temperature in the tests with only CO2, where resistance to pitting susceptibility is maximized due to a decrease in the cation vacancy diffusivity.…”
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A comparative study of the growth of Tetraselmis sp. in large scale fixed depth and decreasing depth raceway ponds by Das, Probir

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Opportunities, challenges and trade-offs with decreasing avoidable food waste in the UK by Patel, Shivalee

“…This study looks at the main stages of the food supply chain, and amasses the opportunities, challenges and trade-offs associated with surplus food redistribution to the UK economy. It highlights points in the food system where interventions can be made, to improve food’s circularity and sustainability potential. …”
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A CFD- RSM study of cuttings transport in non-Newtonian drilling fluids: Impact of operational parameters by Awad A.M.

“…The results indicate that there are only a few cases of inadequate hole cleaning that drill-pipe rotation cannot control, and those cases are associated with the operation in vertical wellbore sections. …”
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Comparative skull analysis suggests species-specific captivity-related malformation in lions (Panthera leo) by Saragusty, Joseph

“…Lion (Panthera leo) populations have dramatically decreased worldwide with a surviving population estimated at 32,000 across the African savannah. …”
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Necrotizing Fasciitis caused by Streptococcus pyogenes: A case report and literature review of disease diagnosis and management by Aziz, Hassan A

“…Background: A 55-year-old male presented to the emergency room at a local hospital complaining of chest discomfort and severe left elbow pain. …”
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Metformin attenuates V-domain Ig suppressor of T-cell activation through the aryl hydrocarbon receptor pathway in Melanoma: In Vivo and In Vitro Studies by Fawaz E., Alanazi

“…Melanoma is an aggressive skin cancer with a high rate of metastasis to other organs. Recent studies specified the overexpression of V-domain Ig suppressor of T-cell activation (VISTA) and Aryl Hydrocarbon Receptor (AHR) in melanoma. …”
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Metformin attenuates V-domain Ig suppressor of T-cell activation through the aryl hydrocarbon receptor pathway in Melanoma: In Vivo and In Vitro Studies by Fawaz E., Alanazi

“…Melanoma is an aggressive skin cancer with a high rate of metastasis to other organs. Recent studies specified the overexpression of V-domain Ig suppressor of T-cell activation (VISTA) and Aryl Hydrocarbon Receptor (AHR) in melanoma. …”
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Fruit and vegetable consumption and cardiovascular diseases among jordanians: A case-control study by Tayyem, F. Reema

“…This study aimed to assess the possible preventive effect of fruit and vegetable consumption on developing CVD. Methods: A total of 398 participants (205 cases and 193 controls) referred for elective coronary angiography with clinical suspicion of coronary artery disease to Prince Hamza Hospital in Amman were enrolled in this case-control study. …”
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Mediterranean Dietary Pattern is Associated with Lower Odds of Gastric Cancer: A Case–Control Study by Tayyem, Reema

“…This study aims to assess the impact of several dietary choices on the risk of GC among newly diagnosed Jordanian patients. Methods: A case–control study was conducted at major oncology centers and hospitals in Jordan. …”
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Demographic characteristics, laboratory features and complications in 346 cases of brucellosis: A retrospective study from Qatar by Varikkodan, Irfan

“…Objectives: To study the epidemiology and laboratory findings and outcomes of human brucellosis in the state of Qatar. Methods: A retrospective study involving adult patients with a definitive diagnosis of brucellosis was conducted. …”
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Food groups and the risk of colorectal cancer: results from a Jordanian case-control study by Abu-Mweis, Suhad S.

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