Image_1_Tocilizumab (TCZ) Decreases Angiogenesis in Rheumatoid Arthritis Through Its Regulatory Effect on miR-146a-5p and EMMPRIN/CD147.jpeg by Devy Zisman (11838428)

“…Transfection of HT1080 cells with the miR-146a-5p mimic, decreased the accumulation of EMMPRIN, VEGF and MMP-9. …”

TUDCA decreases ER stress in HOX neonatal rat lungs. by Kirkwood A. Pritchard Jr. (13449794)

“…(<b>C</b>) In IHC stain, P-IRE1α levels are decreased (40.8±3.5 A.U. <i>vs</i> 53.1±5.0 A.U., p<0.001, n = 6, 3 for each sex) in chronic hyperoxia exposed neonatal rat lungs by TUDCA. …”

Ce6 decreases the amount of TMV PQS5 upon photo-irradiation. by Congbao Xie (17599247)

Analysis of human aneurysmal and normal aortic tissues. by Dong Ma (584680)

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The effect of Mdivi-1 administration on cell apoptosis in vivo. by Dong Ma (584680)

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Klf5 expression is down-regulated in the ruptured human and experimental AAA. by Dong Ma (584680)

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SMC-specific knockout of Klf5 (smcKlf5^−/−) exacerbates the progression of Ang II–induced AAA by facilitating ROS formation. by Dong Ma (584680)

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Representative TUNEL- and DAPI-stained sections from the abdominal aortas of young and old WT and smcKlf5^−/− mice following 28 days of Ang II infusion. by Dong Ma (584680)

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Young (3 months) or old (18 months) WT and smcKlf5^−/− mice were infused with Ang II for 28 days. by Dong Ma (584680)

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Synthesis and Biological Evaluation of Peripheral 5HT_2B Antagonists for Liver Fibrosis by Jihyeon Yoon (8705706)

“…<b>19c</b> markedly reduced fibrotic deposition, with a decrease in fibrosis stage and area in the CCl₄-induced liver fibrosis mouse model. …”

Synthesis and Biological Evaluation of Peripheral 5HT_2B Antagonists for Liver Fibrosis by Jihyeon Yoon (8705706)

“…<b>19c</b> markedly reduced fibrotic deposition, with a decrease in fibrosis stage and area in the CCl₄-induced liver fibrosis mouse model. …”

Klf5 down-regulation leads to human VSMC senescence. by Dong Ma (584680)

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Conditional ablation of <i>Ybx1</i> leads to a reduction in cortical progenitor cell pool and a decrease in cortical thickness. by Jian Zhang (1682)

Simulated effects of increased pCREB combined with decreased pCaMKIIα on bistability. by Yili Zhang (540283)

“…<p>(A1) Modification of model. Increased basal phosphorylation of CREB <i>k</i>_{<i>basalp_creb</i>}, concurrent with decreased basal phosphorylation of CaMKIIα <i>k</i>_{<i>basalp_CaMKII</i>}, in the absence of the effects of MeCP2/HDAC2/Sin3a (red) ([<i>E</i>_<i>comp</i>] = 0; [<i>E</i>_<i>MeCP2</i>] = 0). …”

A picture of the 50 L small-scale environmental chamber. by Eloise Parry-Nweye (7548998)

50 WT 5′ and 3′ terminal nts of the S1 gene are sufficient to package a non-MRV gene into infectious virions. by Debarpan Dhar (724473)

Image5_The G protein biased serotonin 5-HT2A receptor agonist lisuride exerts anti-depressant drug-like activities in mice.JPEG by Vladimir M. Pogorelov (133492)

“…Despite these benefits, the hallucinogenic actions of these drugs at the serotonin 2A receptor (5-HT2AR) limit their clinical use in diverse settings. …”

Growth on stiff substrate results in mild lifespan extension but a decrease in organismal health. by Maria Oorloff (19658113)

LOH resulting in 189R/R produces a strong decrease in drug susceptibility. by Pétra Vande Zande (17628246)

Image1_The serotonin receptor 5-HT2A modulates lifespan and protein feeding in Drosophila melanogaster.pdf by Allyson S. Munneke (14200148)

“…Loss of the 5-HT2A receptor extends lifespan and induces a resistance to changes in dietary protein that are normally detrimental to lifespan. 5-HT2A^−/− null mutant flies also display decreased protein feeding and protein content in the body. …”