Discovery and Development of <i>N</i>‑[4-(1-Cyclobutylpiperidin-4-yloxy)phenyl]-2-(morpholin-4-yl)acetamide Dihydrochloride (SUVN-G3031): A Novel, Potent, Selective, and Orally Act... by Ramakrishna Nirogi (2025910)

“…A series of chemical optimizations guided by in vitro affinity at a histamine H₃ receptor (H₃R), physicochemical properties, and pharmacokinetics in rats resulted in identification of <i>N</i>-[4-(1-cyclobutyl-piperidin-4-yloxy)­phenyl]-2-(morpholin-4-yl)­acetamide dihydrochloride (<b>17v</b>, SUVN-G3031) as a clinical candidate. …”

GnRH responsive transcripts increase after ovariectomy and decrease after Antide treatment. by Maria K. Herndon (2212282)

The acetylation levels of histones at histone gene promoters decrease in cells with p300 knockdown. by Hongpeng He (348094)

“…<p>(A) p300 downregulation by siRNA resulted in cell accumulation in G1 phase. siRNA transfection was as described in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0022088#pone-0022088-g002" target="_blank">Fig. 2A</a>. …”

DataSheet_1_Remodeling of T Cell Dynamics During Long COVID Is Dependent on Severity of SARS-CoV-2 Infection.pdf by Milena Wiech (111682)

“…In particular, CD8+ T cells exhibit a high proportion of CD57+ terminal effector cells, together with significant decrease of naïve cell population, augmented granzyme B and IFN-γ production and unresolved inflammation 6 months after infection. …”

Statistical analysis of relative decrease in prey abundance in presence of T6SS+ parental strain. by Marta Rudzite (15991136)

EG-specific MMP-1 RNAi does not block glial infiltration or pruning. by Vanessa Kay Miller (19775496)

Critical roles of Thy28 associated with the <i>Pax5</i> 1A promoter in <i>Pax5</i> expression. by Toshitsugu Fujita (25023)

“…<b>(C)</b> Interaction of Thy28 with the <i>Pax5</i> 1A promoter. The primer positions for real-time PCR are shown (upper panel). …”

SEM image of (a) Lanthanum strontium cobalt oxide (b) Ba₇Nb₄MoO₂₀ electrolyte and (c) Gadolinium-doped ceria. by Nacer Badi (14046883)

FTIR spectra of (a) Ba₇Nb₄MoO₂₀ electrolyte (b) Gadolinium-doped ceria and (c) Lanthanum strontium cobalt oxide. by Nacer Badi (14046883)

miR-17-92 expression correlates with ETS transcription factors Spi-1 and Fli-1 decrease during 745A#44 cells differentiation. by Samer Kayali (133888)

Decrease of the DXR-induced genotoxicity and nongenotoxic effects of Theobroma cacao revealed by micronucleus assay by M. F. G. Boriollo (4894975)

Transcriptional repression of synapse-related genes and a decrease in spine density by AAV-hGATA1 and AAV-hGATA2 in DG of the rat hippocampus. by Miyeon Choi (648726)

“…(h) Density of dendritic spines (arrowheads) was significantly decreased in AAV-hGATA1- and AAV-hGATA2-injected rats compared with AAV-ctl-injected rats (a main effect of virus, <i>F</i>_2,13 = 12.9, <i>P</i><0.0001; AAV-hGATA1: <i>F</i>_1,10 = 21.15, <i>P</i> = 0.0009; AAV-hGATA2: <i>F</i>_1,7 = 5.63, <i>P</i> = 0.04). …”

P28 GST enzymatic activity is essential to decrease inflammation in TNBS-induced colitis. by Aurore Sarazin (6162698)

Top 5 templates of CNN1 isoform 2 by PHYRE2 tool. by Muhammad Bilal Azmi (14519913)

“…Further, molecular docking experimentation of CNN1 showed the significant interactions at S102, L105, A106, K123, Y124 with five selected PTB-drugs, Allylestrenol (-7.56 kcal/mol), Hydroxyprogesterone caproate (-8.19 kcal/mol), Retosiban (-9.43 kcal/mol), Ritodrine (-7.39 kcal/mol) and Terbutaline (-6.87 kcal/mol). …”

Spatio-temporal patterns of attacks on human and economic losses from wildlife in Chitwan National Park, Nepal - Fig 5 by Babu Ram Lamichhane (4093201)

Table5_Potential Target Analysis of Triptolide Based on Transcriptome-Wide m6A Methylome in Rheumatoid Arthritis.xlsx by Danping Fan (5913008)

“…Molecular docking and in vitro experiment suggested that TP and IGF2BP3 had a high binding affinity and TP could decrease the mRNA expression of IGF2BP3 in PBMCs and MH7A.This research established a transcriptional map of m⁶A in RA PBMCs and displayed the hidden association between RNA methylation alterations and associated genes in RA. …”

Characterization of cisplatin resistance phenotype in A2780 and A2780cp cells. by Hadi Alizadeh (20854757)

<i>HD</i> CAG and 3-NP Shared Decreased Expression of Glycolytic Genes by Jong-Min Lee (105338)

Table5_Identification of a novel Scn3b mutation in a Chinese Brugada syndrome pedigree: implications for Nav1.5 electrophysiological properties and intracellular distribution of Na... by Jun Fan (246573)

“…Confocal imaging and Western blot analysis demonstrated decreased plasma membrane localization of SCN3B and SCN5A in the P87l group. …”

EC50 and percentage decrease in intracellular <i>Listeria</i> viability for effective compounds. by Marie-Eve Charbonneau (5658799)