Table_1_Safety, tolerability, pharmacokinetics, pharmacodynamics, and efficacy of WBP216, a novel IL-6 monoclonal antibody, in patients with rheumatoid arthritis: A phase Ia random... by Xiaomei Leng (614420)

“…</p>Methods<p>In this double-blind, placebo-controlled, SAD, phase Ia study, patients with RA were randomized in a 3:1 (Group A1, 10 mg) and 6:2 (Group A2, 30 mg; Group A3, 75 mg; Group A4, 150 mg; Group A5, 300 mg) ratios to receive either ascending doses of WBP216 or placebo subcutaneously. …”

The optimal asset allocation between the S&P500 index and a risk-free asset as a function of the risk-free interest rate <i>r</i>_<i>f</i>. by Haim Levy (252011)

“…The bold line shows the optimal allocation to the stock index for a PT investor with the parameters in [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0248904#pone.0248904.ref023" target="_blank">23</a>]: <i>α</i> = <i>β</i> = 0.88, <i>λ</i> = 2.25 given by <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0248904#pone.0248904.e007" target="_blank">Eq 5</a>. …”

A novel second-generation platinum derivative and evaluation of its anti-cancer potential by Habibe Yilmaz (4865200)

The global impacts of US climate policy: a model simulation using GCAM-TU and MAGICC by Han Chen (228557)

“…<p>To assess the potential impacts of the US withdrawal from the Paris Agreement, this study applied GCAM-TU (an updated version of the Global Change Assessment Model) to simulate global and regional emission pathways of energy-related CO₂, which show that US emissions in 2100 would reduce to −2.4 Gt, −0.7 Gt and −0.2 Gt under scenarios of RCP2.6, RCP3.7 and RCP4.5, respectively. Two unfavourable policy scenarios were designed, assuming a temporary delay and a complete stop for US mitigation actions after 2015. …”

Inequalities in Alcohol-Related Mortality in 17 European Countries: A Retrospective Analysis of Mortality Registers by Johan P. Mackenbach (147412)

“…<div><p>Background</p><p>Socioeconomic inequalities in alcohol-related mortality have been documented in several European countries, but it is unknown whether the magnitude of these inequalities differs between countries and whether these inequalities increase or decrease over time.</p><p>Methods and Findings</p><p>We collected and harmonized data on mortality from four alcohol-related causes (alcoholic psychosis, dependence, and abuse; alcoholic cardiomyopathy; alcoholic liver cirrhosis; and accidental poisoning by alcohol) by age, sex, education level, and occupational class in 20 European populations from 17 different countries, both for a recent period and for previous points in time, using data from mortality registers. …”

The interaction between tonic GABA_AR signaling and glutamatergic activity. by Michelle Day (11617621)

“…Increasing depolarization (2–3 mV to 10⁻⁵ S/cm² density) was accompanied by a dendritic spike in response to a glutamatergic input that was subthreshold in the absence of tonic GABA activation. …”

A systematic review and meta-analysis of preclinical trials testing anti-toxin therapies for <i>B</i>. <i>anthracis </i>infection: A need for more robust study designs and results by Wanying Xu (3765427)

“…Across all agents and species, agents decreased RR [0.64(0.52,0.79); I² = 5.3%, p = 0.39].…”

The distribution of Ephemeroptera, Plecoptera and Trichoptera in a Norwegian alpine catchment in relation to environmental gradients by Nina Kristine S. Helland (21584459)

SSD - a free software for designing multimeric mono-, bi- and trivalent shRNAs by Gabriel José de Carli (8526942)

Accounting for monogastric livestock as a driver in global land use and cover change assessments by David A. Eitelberg (3603071)

Analysis of the care of patients with Diabetes Mellitus and Hypertension: the experience of a small municipality in Brazil by Monica Viegas Andrade (5621213)

Preparation and in vitro release profiling of PLGA microspheres containing BSA as a model protein by Nazanin Dabaghi (12849110)

Dragonflies and Damselflies in a region of the Triângulo Mineiro, Minas Gerais: checklist and taxonomic additions by Henrique Venâncio (12831251)

A Bayesian Nonlinear Mixed-Effects Regression Model for the Characterization of Early Bactericidal Activity of Tuberculosis Drugs by Divan Aristo Burger (645493)

Adherence to medication before and after the use of a Drug-Dispensing System with usage control by Liliana Batista Vieira (5960912)

“…After the use of the system, 100% were considered as "more adherent" (p < 0.01), the means of the systolic blood pressure decreased 23.7 mmHg (p=0.000), the diastolic blood pressure decreased 12.1 mmHg (p=0.004) and glycemia diminished 79.3 mg/dl (p=0.000). …”

Table_1_A Multi-Ingredient Nutritional Supplement in Combination With Resistance Exercise and High-Intensity Interval Training Improves Cognitive Function and Increases N-3 Index i... by Kirsten E. Bell (4256167)

“…Forty-nine sedentary men [age: 73 ± 6 years (mean ± SD); body mass index: 28.5 ± 3.6 kg/m²] were randomized to consume a supplement (SUPP n = 25; 1500 mg n-3 polyunsaturated fatty acids, 30 g whey protein, 2.5 g creatine, 500 IU vitamin D, and 400 mg calcium) or control beverage (CON n = 24; 22 g maltodextrin) twice daily for 20 weeks consisting of Phase 1: SUPP/CON followed by Phase 2: 12-week resistance exercise training plus high-intensity interval training, while continuing to consume the study beverages (SUPP/CON + EX). …”

Table_1_A Multi-Ingredient Nutritional Supplement in Combination With Resistance Exercise and High-Intensity Interval Training Improves Cognitive Function and Increases N-3 Index i... by Kirsten E. Bell (4256167)

“…Forty-nine sedentary men [age: 73 ± 6 years (mean ± SD); body mass index: 28.5 ± 3.6 kg/m²] were randomized to consume a supplement (SUPP n = 25; 1500 mg n-3 polyunsaturated fatty acids, 30 g whey protein, 2.5 g creatine, 500 IU vitamin D, and 400 mg calcium) or control beverage (CON n = 24; 22 g maltodextrin) twice daily for 20 weeks consisting of Phase 1: SUPP/CON followed by Phase 2: 12-week resistance exercise training plus high-intensity interval training, while continuing to consume the study beverages (SUPP/CON + EX). …”

Intrinsic and extrinsic fluorescence spectroscopy of the protease 1147. by Hossein Tarrahimofrad (9016994)

A partial genome assembly of the miniature parasitoid wasp, <i>Megaphragma amalphitanum</i> by Fedor S. Sharko (6575339)

Changes in Dietary Fat Intake and Projections for Coronary Heart Disease Mortality in Sweden: A Simulation Study by Lena Björck (77400)

“…We assumed that there would be moderate improvements in smoking (5%), salt intake (1g/day) and physical inactivity (5% decrease) to continue recent, positive trends.…”