Table_7_One-carbon pathway metabolites are altered in the plasma of subjects with Down syndrome: Relation to chromosomal dosage.xlsx by Beatrice Vione (10734998)

“…Several studies demonstrated that trisomy 21 causes an alteration in the metabolic profile, involving among all the one-carbon cycle.</p>Methods<p>We performed enzyme-linked immunosorbent assays (ELISAs) to identify the concentration of 5 different intermediates of the one-carbon cycle in plasma samples obtained from a total of 164 subjects with DS compared to 54 euploid subjects. …”

Image_2_One-carbon pathway metabolites are altered in the plasma of subjects with Down syndrome: Relation to chromosomal dosage.PDF by Beatrice Vione (10734998)

“…Several studies demonstrated that trisomy 21 causes an alteration in the metabolic profile, involving among all the one-carbon cycle.</p>Methods<p>We performed enzyme-linked immunosorbent assays (ELISAs) to identify the concentration of 5 different intermediates of the one-carbon cycle in plasma samples obtained from a total of 164 subjects with DS compared to 54 euploid subjects. …”

Image_2_One-carbon pathway metabolites are altered in the plasma of subjects with Down syndrome: Relation to chromosomal dosage.PDF by Beatrice Vione (10734998)

“…Several studies demonstrated that trisomy 21 causes an alteration in the metabolic profile, involving among all the one-carbon cycle.</p>Methods<p>We performed enzyme-linked immunosorbent assays (ELISAs) to identify the concentration of 5 different intermediates of the one-carbon cycle in plasma samples obtained from a total of 164 subjects with DS compared to 54 euploid subjects. …”

Table_11_One-carbon pathway metabolites are altered in the plasma of subjects with Down syndrome: Relation to chromosomal dosage.xlsx by Beatrice Vione (10734998)

“…Several studies demonstrated that trisomy 21 causes an alteration in the metabolic profile, involving among all the one-carbon cycle.</p>Methods<p>We performed enzyme-linked immunosorbent assays (ELISAs) to identify the concentration of 5 different intermediates of the one-carbon cycle in plasma samples obtained from a total of 164 subjects with DS compared to 54 euploid subjects. …”

Table_9_One-carbon pathway metabolites are altered in the plasma of subjects with Down syndrome: Relation to chromosomal dosage.xlsx by Beatrice Vione (10734998)

“…Several studies demonstrated that trisomy 21 causes an alteration in the metabolic profile, involving among all the one-carbon cycle.</p>Methods<p>We performed enzyme-linked immunosorbent assays (ELISAs) to identify the concentration of 5 different intermediates of the one-carbon cycle in plasma samples obtained from a total of 164 subjects with DS compared to 54 euploid subjects. …”

Table_10_One-carbon pathway metabolites are altered in the plasma of subjects with Down syndrome: Relation to chromosomal dosage.xlsx by Beatrice Vione (10734998)

“…Several studies demonstrated that trisomy 21 causes an alteration in the metabolic profile, involving among all the one-carbon cycle.</p>Methods<p>We performed enzyme-linked immunosorbent assays (ELISAs) to identify the concentration of 5 different intermediates of the one-carbon cycle in plasma samples obtained from a total of 164 subjects with DS compared to 54 euploid subjects. …”

Table_6_One-carbon pathway metabolites are altered in the plasma of subjects with Down syndrome: Relation to chromosomal dosage.xlsx by Beatrice Vione (10734998)

“…Several studies demonstrated that trisomy 21 causes an alteration in the metabolic profile, involving among all the one-carbon cycle.</p>Methods<p>We performed enzyme-linked immunosorbent assays (ELISAs) to identify the concentration of 5 different intermediates of the one-carbon cycle in plasma samples obtained from a total of 164 subjects with DS compared to 54 euploid subjects. …”

Table_9_One-carbon pathway metabolites are altered in the plasma of subjects with Down syndrome: Relation to chromosomal dosage.xlsx by Beatrice Vione (10734998)

“…Several studies demonstrated that trisomy 21 causes an alteration in the metabolic profile, involving among all the one-carbon cycle.</p>Methods<p>We performed enzyme-linked immunosorbent assays (ELISAs) to identify the concentration of 5 different intermediates of the one-carbon cycle in plasma samples obtained from a total of 164 subjects with DS compared to 54 euploid subjects. …”

Table_2_One-carbon pathway metabolites are altered in the plasma of subjects with Down syndrome: Relation to chromosomal dosage.xlsx by Beatrice Vione (10734998)

“…Several studies demonstrated that trisomy 21 causes an alteration in the metabolic profile, involving among all the one-carbon cycle.</p>Methods<p>We performed enzyme-linked immunosorbent assays (ELISAs) to identify the concentration of 5 different intermediates of the one-carbon cycle in plasma samples obtained from a total of 164 subjects with DS compared to 54 euploid subjects. …”

Table_6_One-carbon pathway metabolites are altered in the plasma of subjects with Down syndrome: Relation to chromosomal dosage.xlsx by Beatrice Vione (10734998)

“…Several studies demonstrated that trisomy 21 causes an alteration in the metabolic profile, involving among all the one-carbon cycle.</p>Methods<p>We performed enzyme-linked immunosorbent assays (ELISAs) to identify the concentration of 5 different intermediates of the one-carbon cycle in plasma samples obtained from a total of 164 subjects with DS compared to 54 euploid subjects. …”

Table_1_One-carbon pathway metabolites are altered in the plasma of subjects with Down syndrome: Relation to chromosomal dosage.xlsx by Beatrice Vione (10734998)

“…Several studies demonstrated that trisomy 21 causes an alteration in the metabolic profile, involving among all the one-carbon cycle.</p>Methods<p>We performed enzyme-linked immunosorbent assays (ELISAs) to identify the concentration of 5 different intermediates of the one-carbon cycle in plasma samples obtained from a total of 164 subjects with DS compared to 54 euploid subjects. …”

Data_Sheet_2_One-carbon pathway metabolites are altered in the plasma of subjects with Down syndrome: Relation to chromosomal dosage.DOCX by Beatrice Vione (10734998)

“…Several studies demonstrated that trisomy 21 causes an alteration in the metabolic profile, involving among all the one-carbon cycle.</p>Methods<p>We performed enzyme-linked immunosorbent assays (ELISAs) to identify the concentration of 5 different intermediates of the one-carbon cycle in plasma samples obtained from a total of 164 subjects with DS compared to 54 euploid subjects. …”

Data from: Viviparity does not affect the numbers and sizes of reptile offspring by Shai Meiri (394933)

“…We attribute this paradoxical result to (1) strong selection on optimal offspring sizes, unaffected by parity mode, (2) the lack of a larval stage in amniotes, favouring large eggs even in the ancestral oviparous mode, and (3) the ability of viviparous females to decrease the mass of uterine embryos by reducing extra-embryonic water stores. …”

<b>Bleomycin-induced lung fibrosis and dysfunction is exacerbated by G6PD deficiency</b> by Sachin Gupte (8211615)

“…In the present study, our objective was to determine altered metabolic pathways that contribute to Bleomycin sulfate (BLM; 5 mg/kg)-induced PF in rats. We determined the effects of nebulized BLM on PF in CRISPR-edited rats expressing glucose-6-phosphate dehydrogenase (G6PD) variant (S188F; G6PD^S188F) and their wild-type (WT) littermates. …”

Table1_Pulmonary vascular adaptations to hypoxia in elite breath-hold divers.pdf by Thomas Kjeld (5685143)

“…</p>Conclusion<p>Our results contrast with previous studies, that demonstrated similar lung gas transfer in BHD and matched controls. We conclude that elite BHD 1) have a lower diffusion constant than matched controls, and 2) gradually decrease PBV during apnea and in turn increase V_A/Q to increase alveolar oxygen delivery during maximum apnea. …”

Table1_Pulmonary vascular adaptations to hypoxia in elite breath-hold divers.pdf by Thomas Kjeld (5685143)

“…</p>Conclusion<p>Our results contrast with previous studies, that demonstrated similar lung gas transfer in BHD and matched controls. We conclude that elite BHD 1) have a lower diffusion constant than matched controls, and 2) gradually decrease PBV during apnea and in turn increase V_A/Q to increase alveolar oxygen delivery during maximum apnea. …”

Table2_Pulmonary vascular adaptations to hypoxia in elite breath-hold divers.pdf by Thomas Kjeld (5685143)

“…</p>Conclusion<p>Our results contrast with previous studies, that demonstrated similar lung gas transfer in BHD and matched controls. We conclude that elite BHD 1) have a lower diffusion constant than matched controls, and 2) gradually decrease PBV during apnea and in turn increase V_A/Q to increase alveolar oxygen delivery during maximum apnea. …”

Video1_Pulmonary vascular adaptations to hypoxia in elite breath-hold divers.mp4 by Thomas Kjeld (5685143)

“…</p>Conclusion<p>Our results contrast with previous studies, that demonstrated similar lung gas transfer in BHD and matched controls. We conclude that elite BHD 1) have a lower diffusion constant than matched controls, and 2) gradually decrease PBV during apnea and in turn increase V_A/Q to increase alveolar oxygen delivery during maximum apnea. …”

Table1_Pulmonary vascular adaptations to hypoxia in elite breath-hold divers.pdf by Thomas Kjeld (5685143)

“…</p>Conclusion<p>Our results contrast with previous studies, that demonstrated similar lung gas transfer in BHD and matched controls. We conclude that elite BHD 1) have a lower diffusion constant than matched controls, and 2) gradually decrease PBV during apnea and in turn increase V_A/Q to increase alveolar oxygen delivery during maximum apnea. …”

Table2_Pulmonary vascular adaptations to hypoxia in elite breath-hold divers.pdf by Thomas Kjeld (5685143)

“…</p>Conclusion<p>Our results contrast with previous studies, that demonstrated similar lung gas transfer in BHD and matched controls. We conclude that elite BHD 1) have a lower diffusion constant than matched controls, and 2) gradually decrease PBV during apnea and in turn increase V_A/Q to increase alveolar oxygen delivery during maximum apnea. …”