Epigenetic DNA Methylation Signatures Associated With the Severity of Paget’s Disease of Bone by Ilhame Diboun (3522413)

“…Additionally, methylation profiles in 11 regions showed Bonferroni-significant association with disease severity including six islands (located in VCL, TBX5, CASZ1, ULBP2, NUDT15 and SQSTM1), two gene bodies (CXCR6 and DENND1A), and 3 promoter regions (RPL27, LINC00301 and VPS29). …”

Divergent Biochemical Properties and Disparate Impact of Arrhythmogenic Calmodulin Mutations on Zebrafish Cardiac Function by Sahar I. Da'as (17128747)

“…In cardiac muscle, CaM modulates directly or indirectly the activity of several proteins that play a key role in excitation‐contraction coupling (ECC), such as ryanodine receptor type 2 (RyR2), l‐type Ca²⁺ (Ca_v1.2), sodium (NaV1.5) and potassium (KV7.1) channels. …”

Chamber investigation of the formation and transformation of secondary organic aerosol in mixtures of biogenic and anthropogenic volatile organic compounds by Aristeidis Voliotis (16563090)

“…The observed average SOA particle mass yields (the organic particle mass produced for a mass of VOC consumed) in descending order were found for the following systems: α-pinene (32 ± 7 %), α-pinene–o-cresol (28 ± 9 %), α-pinene at 1/2 initial reactivity (21 ± 5 %), α-pinene–isoprene (16 ± 1 %), α-pinene at 1/3 initial reactivity (15 ± 4 %), o-cresol (13 ± 3 %), α-pinene–o-cresol–isoprene (11 ± 4 %), o-cresol at 1/2 initial reactivity (11 ± 3 %), o-cresol–isoprene (6 ± 2 %), and isoprene (0 ± 0 %). …”

Salivary α-amylase activity is associated with cardiometabolic and inflammatory biomarkers in overweight/obese, non-diabetic Qatari women by Neyla S. Al Akl (15189997)

“…Additionally, sAAa demonstrated a significant positive association with adiponectin β 0.007 [95% CI 0.001 to 0.01]while concurrently displaying significant negative associations with CRP β -0.02 [95% CI -0.044 to -0.0001], TNF-α β -0.105 [95% CI -0.207 to -0.004], IL-6 β [95% CI -0.39 -0.75 to -0.04], and ghrelin β -5.95 [95% CI -11.71 to -0.20], specifically within the female population.…”

The impact of enteric coating of aspirin on aspirin responsiveness in patients with suspected or newly diagnosed ischemic stroke: prospective cohort study: results from the (ECASIS... by Mohamed Nabil Elshafei (9960500)

“…Univariate and multivariate logistic regression analysis showed that patients treated with EC-ASA were more likely to have a lower rate of non-responders compared to P-ASA (unadjusted OR 0.78; 95% CI 0.20, 3.11); with the risk highest in type 2 diabetic patients with HBA1c > 6.5% (adjusted OR 6; 95% CI 1.02, 35.27; P = 0.047). …”

Overview of Artificial Intelligence–Driven Wearable Devices for Diabetes: Scoping Review by Arfan Ahmed (17541309)

“…<h3>Background</h3><p dir="ltr">Prevalence of diabetes has steadily increased over the last few decades with 1.5 million deaths reported in 2012 alone. …”

Exercise training-induced speeding of VO₂kinetics is not intensity domain-specific or correlated with indices of exercise performance by Erin Calaine Inglis (7042334)

“…Despite significant increases in maximal VO₂ (VO_2max ), estimated lactate threshold (θLT), maximal metabolic steady state (MMSS), and peak power output (PPO) for the intervention groups (p < 0.05), there were no significant correlations from PRE to MID or MID to POST between ΔτVO₂ and Δ V O_2max (r=– 0.221, r = 0.119), ΔPPO (r= – 0.112, r= – 0.017), ΔθLT (r= 0.083, r = 0.142) and ΔMMSS (r= – 0.213, r = 0.049)(p > 0.05).…”

In vitro effects of multi-purpose contact lens disinfecting solutions towards survivability of Acanthamoeba genotype T4 in Malaysia by Hussain, Rosnani Hanim Mohd

“…The incidence of Acanthamoeba keratitis has been increasing since the previous decades, especially among contact lens users. …”
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Fixed Shading Scenarios to Optimize Lighting Performance and Energy Efficiency in Office Buildings Case Study of Dubai Design District by Hamad, Khadije

“…The results in chapter 5 show that the Egg-crate scheme performed most effectively on the office building case study achieving a reduction in energy consumption of 8.2% from the base case result in a year. …”
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From past famines to present crises: The epigenetic impact of maternal malnutrition on offspring health in Gaza by Mohamed Adil Shah Khoodoruth (14589828)

“…Notably, at least one in four households (over half a million people) are facing catastrophic conditions (IPC Phase 5, Catastrophe) according to the IPC.…”

The Effect of Atorvastatin (and Subsequent Metformin) on Adipose Tissue Acylation-Stimulatory-Protein Concentration and Inflammatory Biomarkers in Overweight/Obese Women With Polyc... by Thozhukat Sathyapalan (704787)

“…</p><p><br></p><p dir="ltr">ISRCTN Number: ISRCTN24474824</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Endocrinology<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fendo.2019.00394" target="_blank">https://dx.doi.org/10.3389/fendo.2019.00394</a></p>…”

HIV incidence among people who inject drugs in the Middle East and North Africa: mathematical modelling analysis by Ghina R Mumtaz (18629722)

“…It also delineates injecting drug use role as a driver of the epidemic in the population, and estimates impact of interventions.…”

Mapping geographical inequalities in oral rehydration therapy coverage in low-income and middle-income countries, 2000–17 by Kirsten E Wiens (9153854)

“…<p dir="ltr">Background Oral rehydration solution (ORS) is a form of oral rehydration therapy (ORT) for diarrhoea that has the potential to drastically reduce child mortality; yet, according to UNICEF estimates, less than half of children younger than 5 years with diarrhoea in low-income and middle-income countries (LMICs) received ORS in 2016. …”

Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017 by LBD Double Burden of Malnutrition Collaborators (18567880)

“…Wasting decreased overall across LMICs between 2000 and 2017, from 8.4% (62.3 (55.1–70.8) million) to 6.4% (58.3 (47.6–70.7) million), but is predicted to remain above the World Health Organization’s Global Nutrition Target of <5% in over half of LMICs by 2025. Prevalence of overweight increased from 5.2% (30 (22.8–38.5) million) in 2000 to 6.0% (55.5 (44.8–67.9) million) children aged under 5 years in 2017. …”

The interplay between social media use and problematic internet usage: Four behavioral patterns by Khansa Chemnad (17346994)

“…The total PIU score can range from 6 to 30, with a score above 15 indicating that a person is at risk of PIU. …”

Diagnosis and management of dementia with Lewy bodies by Ian G. McKeith (19725589)

“…Substantial progress has been made since the previous report in the detection and recognition of DLB as a common and important clinical disorder. During that period it has been incorporated into DSM-5, as major neurocognitive disorder with Lewy bodies. …”

Maternal–Neonatal Methylome Signatures In Preterm Birth Revealed By Long-Read DNA Methylation Profiling by BalaSubramani Gattu Linga (19325617)

“…Epigenetic regulation, particularly DNA methylation, is increasingly recognized as a key mediator of these processes, yet dual maternal-neonatal methylation landscapes in PTB remain insufficiently characterized. …”

Ablation of LAT2 Transporter Causes Intramuscular Glutamine Accumulation and Inhibition of Fasting‐Induced Proteolysis by Meritxell Espino‐Guarch (22565774)

“…</p><h3>Results</h3><p dir="ltr">LAT2KO mice experienced a notable reduction in body weight during fasting (WT:14% and LAT2KO:18%, <i>p</i> = 0.02), with a greater reduction in fat mass (0.5‐fold, <i>p</i> = 0.013) and a higher relative retention of muscle mass (1.3‐fold, <i>p</i> = 0.0003) compared with WT. …”

What’s So Great About Home? by Marroum, Marianne

“…She states: “If I considered myself a feminist, then I would label myself. And I prefer not to label myself because I feel when writing about women that I am writing by extension to all human beings.”5 Notwithstanding the above, I propose in this essay to give La maison sans racines and Hikāyat Zahra the general description of a literature of displacement. …”
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Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration by Megan F. Duffy (5713772)

“…</p><h3>Conclusions</h3><p dir="ltr">Our results demonstrate that increases in microglia displaying a reactive morphology and MHC-II expression occur in the substantia nigra in close association with peak numbers of pSyn inclusions, months prior to nigral dopamine neuron degeneration, and suggest that reactive microglia may contribute to vulnerability of SNc neurons to degeneration. …”