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Coevolving residues distant from the ligand binding site are involved in GAF domain function
Published 2025“…Here, we combine computational and experimental approaches to demonstrate that two highly coevolving residues, L267 and F295, distant from the ligand binding site, play a critical role in GAF domain allostery. Statistical Coupling Analysis (SCA) of GAF domain sequences identified these residues, and molecular dynamics (MD) simulations of both apo and holo forms of wild-type and mutant (L267A, F295A) PDE5 GAFa domains revealed significant changes in structural dynamics and cGMP interaction. …”
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Mapping local patterns of childhood overweight and wasting in low- and middle-income countries between 2000 and 2017
Published 2020“…Prevalence of overweight increased from 5.2% (30 (22.8–38.5) million) in 2000 to 6.0% (55.5 (44.8–67.9) million) children aged under 5 years in 2017. …”
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Lifetime prevalence, risk, and treatment of mood and anxiety disorders in Qatar's national mental health study
Published 2024“…</p><h3>Methods</h3><p dir="ltr">We conducted a national phone survey of 5,195 Qatari and Arab residents in Qatar (2019–2022) using the Composite International Diagnostic Interview Version 3.3 and estimated lifetime mood and anxiety defined diagnoses. …”
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Vulnerabilities of the SARS-CoV-2 Virus to Proteotoxicity—Opportunity for Repurposed Chemotherapy of COVID-19 Infection
Published 2020“…A strategy for improved drug therapy is to increase levels of endogenous reactive metabolites for selective toxicity to SARS-CoV-2 by preferential damage to the viral proteome. …”
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DiaNet v2 deep learning based method for diabetes diagnosis using retinal images
Published 2024“…<p dir="ltr">Diabetes mellitus (DM) is a prevalent chronic metabolic disorder linked to increased morbidity and mortality. …”
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Extended Preoperative Chemotherapy Does Not Improve Pathologic Response and Increases Postoperative Liver Insufficiency After Hepatic Resection for Colorectal Liver Metastases
Published 2010“…We evaluated the association between the duration of preoperative chemotherapy with 5-fluorouracil (5-FU), leucovorin, oxaliplatin (FOLFOX) ± bevacizumab, pathologic response, and hepatotoxicity after hepatic resection for CLM. …”
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91
Do high energy-efficient buildings increase overheating risk in cold climates? Causes and mitigation measures required under recent and future climates
Published 2022“…While without adequate ventilation, the overheating risk in high-energy-efficient buildings can be higher than old buildings, where decreasing wall and window U-values and infiltration rate has a greater contribution to the increase of indoor temperature, while decreasing window SHGC has a lower contribution to the decrease in indoor temperature compared to the case with adequate ventilation. …”
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92
Dielectric Properties of Y3Fe5O12 (YIG) Prepared at Different Molarities of NaOH
Published 2020“…The garnets produced were obtained from aqueous iron and yttrium chloride mixtures using different molarities of NaOH (M=2, 3, 4 and 5) at pH=12. The phase formation and crystallography were investigated using X-ray diffraction (XRD), the morphology was investigated using transmission electron microscopy (TEM) and the dielectric properties were measured using an impedance analyzer in the frequency range 0.5 - 5MHz, in a temperature range 22 - 350˚C. …”
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Correlation of MPTP neurotoxicity in vivo with oxidation of MPTP by the brain and blood-brain barrier in vitro in five rat strains
Published 1991“…We studied 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in 5 strains of rats by assessing mortality and brain monoamine changes after MPTP injections into the internal carotid artery. …”
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Mapping geographical inequalities in access to drinking water and sanitation facilities in low-income and middle-income countries, 2000–17
Published 2020“…For piped water, the safest water facility type, access increased from 40·0% (95% uncertainty interval [UI] 39·4–40·7) to 50·3% (50·0–50·5), but was lowest in sub-Saharan Africa, where access to piped water was mostly concentrated in urban centres. …”
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Predictors of prolonged hospitalization among geriatric trauma patients using the modified 5-Item Frailty index in a Middle Eastern trauma center: an 11-year retrospective study
Published 2025“…The modified FI-5 performs well as a predictive tool of prolonged hospitalization in trauma patients with different age groups.…”
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Particle size and pH effects on remediation of chromite ore processing residue using calcium polysulfide (CaS5)
Published 2008“…A long-term bench scale treatability study was performed to assess the ability to remediate chromite ore processing residue (COPR) using calcium polysulfide (CaS5). …”
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Dynamic Compressive Properties of Single Crystal Multi-Principal Element Alloy (MPEA) V₁₀Fe₄₅Co₃₀Cr₁₀Ni₅
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Clinical reappraisal of the composite international diagnostic interview version 3.3 in Qatar's National Mental Health Study
Published 2024“…Concordance was also examined for a diagnoses of post‐traumatic stress disorder based on a short‐form versus full version of the PTSD Checklist for DSM‐5 (PCL‐5).…”