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121
Flavin Adenine Dinucleotide (FAD) and Pyridoxal 5′-Phosphate (PLP) Bind to Sox9 and Alter the Expression of Key Pancreatic Progenitor Transcription Factors
Published 2022“…Pyridoxal 5′-phosphate (PLP), the active form of vitamin B6, also binds to Sox9 and results in a similar increase in pancreatic development markers. …”
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122
D-Dimer, Fibrinogen, and IL-6 in COVID-19 Patients with Suspected Venous Thromboembolism: A Narrative Review
Published 2020“…In contrast, late presentations show evidence of prolonged pro thrombin time (PT) and activated partial thromboplastin (aPTT), increased platelets, and fibrinogen levels. …”
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Differential changes in cyclic adenosine 3′-5′ monophosphate (cAMP) effectors and major Ca2+ handling proteins during diabetic cardiomyopathy
Published 2023“…Diabetic cardiomyopathy (DCM) is associated with differential and time-specific regulation of β-adrenergic receptors and cardiac cyclic nucleotide phosphodiesterases with consequences for total cyclic adenosine 3′-5′ monophosphate (cAMP) levels. We aimed to investigate whether these changes are associated with downstream impairments in cAMP and Ca2+ signalling in a type 1 diabetes (T1D)-induced DCM model. …”
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124
In-situ grown ternary metal hydroxides@3D oriented crumpled V₂C MXene sheets for improved electrocatalytic oxygen evolution reaction
Published 2024“…As a result, the NiFeCr@3D V₂C-MX composite has shown an excellent electrocatalytic activity with an overpotential of 410 mV at a current density of 200 mA cm⁻², Tafel slope of 100 mV dec in 1M KOH. …”
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125
Ischemic stroke in the setting of supratherapeutic International Normalized Ratio following coronavirus disease 2019 infection: a case report
Published 2023“…<h3>Background</h3> <p>SARS-CoV-19 infection is associated with an increased risk of thrombotic events. …”
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Effect of Intravenous Mannitol on Intraocular Pressure Changes in Vitrectomized and Non-Vitrectomized Eyes: A Systematic Review and Meta-Analysis
Published 2024“…R software (V 4.3) was used for statistical analysis.</p><h3>Results</h3><p dir="ltr">Our search included five studies of both vitrectomized (145 eyes) and non-vitrectomized eyes (91 eyes). …”
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128
Efficacy and safety of the newer oral hypoglycemic agents in patients with T2DM during Ramadan: A systematic review and meta-analysis
Published 2020“…Quality assessment was done using the ROBINS-I and Cochrane tools for risk of bias and analyses were performed using RevMan version 5.3.</p><h3>Results</h3><p dir="ltr">A total of 20 studies were included in the meta-analysis. …”
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129
Global, regional, and national burden of household air pollution, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021
Published 2025“…Using a systematic review of the epidemiological literature and a newly developed meta-regression tool (meta-regression: Bayesian, regularised, trimmed), we derived disease-specific, non-parametric exposure–response curves to estimate relative risk as a function of PM2·5 concentration. …”
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130
Association between body mass index (BMI) percentile and asthma in children of 5–12 years old: A case–control study using electronic medical records in Primary Health Care Corporat...
Published 2019“…Most epidemiological studies have proposed that a high body mass index (BMI) at infancy and early childhood increases the risk of asthma in children. …”
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Direct Oral Anticoagulants Compared to Warfarin in Patients with Intermediate‐ to High‐Risk Pulmonary Embolism: A Systematic Review and Meta‐Analysis
Published 2025“…</p><h3>Results</h3><p dir="ltr">Six studies, five observational and one randomized (n = 553 patients, out of which 45.7% received advanced therapy), were included in our meta‐analysis. …”
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133
Exendin-4 promotes GSIS without increasing β-cell number through upregulation of glucose-sensing apparatus and mitochondrial oxidative phosphorylation machinery genes in hPSC-deriv...
Published 2023“…However, GSIS data showed no difference in c-peptide secretion between low (2.8mM) and high (20 mM) glucose but high response to direct cellular depolarization-mediated c-peptide by KCl; suggesting a lack of functional β-cells. Interestingly, addition of Exendin-4 (50 nM) during the last 3 days of the differentiation significantly enhanced GSIS associated with increased expression of glucose-sensing apparatus genes (Glut2, G6P2C, GCK) and genes encoding mitochondrial oxidative phosphorylation machinery.…”
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134
Theoretical and experimental investigations of vanadium pentoxide–based electrocatalysts for the hydrogen evolution reaction in alkaline media
Published 2024“…Herein, we investigate the fine-tuning of orthorhombic V<sub>2</sub>O<sub>5</sub>-based electrocatalysts as candidates for HER through a scalable two-step sol–gel calcination procedure. …”
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135
The molecular mechanisms of apoptosis accompanied with the epigenetic regulation of the NY-ESO-1 antigen in non-small lung cancer cells treated with decitabine (5-aza-CdR)
Published 2023“…These results reiterate the decisive role of 5-Aza-CdR in lung cancer treatment since it induces the epigenetic regulation of NY-ESO-1 antigen, inhibits cell proliferation, increases apoptosis, and decreases invasiveness.…”
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Deciphering the In vitro Role of microRNAs miR-21-3p and miR-222-5p In the Regulation of Clostridioides difficile Flagellin-Induced Inflammation
Published 2024“…Western blot and pathway analyses demonstrated that miR-222-5p and miR-21-3p overexpression increased phosphorylation of p65, a key component of the NF-κB complex, while their knockdown reduced p65 phosphorylation. …”
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Evapotranspiration and water availability response to climate change in the Middle East and North Africa
Published 2021“…Outcomes reveal that the MENA region is indeed vulnerable to a surge in temperature, which can increase evapotranspiration losses and decrease water availability. …”
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Role of Active Morphing in the Aerodynamic Performance of Flapping Wings in Formation Flight
Published 2021“…Migratory birds have the ability to save energy during flight by arranging themselves in a V-formation. This arrangement enables an increase in the overall efficiency of the group because the wake vortices shed by each of the birds provide additional lift and thrust to every member. …”
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Review on COVID-19 diagnosis models based on machine learning and deep learning approaches
Published 2021“…COVID-19 is the disease evoked by a new breed of coronavirus called the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). …”
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