Glycemic outcomes of Advanced Hybrid Closed Loop system in children and adolescents with Type 1 Diabetes, previously treated with Multiple Daily Injections (MiniMed 780G system in... حسب Goran Petrovski (129836)

"…HbA1c decreased from 8.6 ± 1.7% (70 ± 18.6 mmol/mol) at baseline, to 6.5 ± 0.7% (48 ± 7.7 mmol/mol) at the end of the study (<i>p</i> = 0.001). …"

Exendin-4 promotes GSIS without increasing β-cell number through upregulation of glucose-sensing apparatus and mitochondrial oxidative phosphorylation machinery genes in hPSC-deriv... حسب Abdoulaye Diane (14152749)

"…However, GSIS data showed no difference in c-peptide secretion between low (2.8mM) and high (20 mM) glucose but high response to direct cellular depolarization-mediated c-peptide by KCl; suggesting a lack of functional β-cells. Interestingly, addition of Exendin-4 (50 nM) during the last 3 days of the differentiation significantly enhanced GSIS associated with increased expression of glucose-sensing apparatus genes (Glut2, G6P2C, GCK) and genes encoding mitochondrial oxidative phosphorylation machinery.…"

The promise of tirzepatide: A narrative review of metabolic benefits حسب Sara Sokary (17337724)

"…Moreover, tirzepatide exhibited favorable effects on glycemic control, with notable reductions in HbA1c levels ranging from 20.4 mmol/mol with the 5 mg dose to 28.2 mmol/mol with the 15 mg dose, following treatment durations lasting 40–52 weeks. …"

Theoretical and experimental investigations of vanadium pentoxide–based electrocatalysts for the hydrogen evolution reaction in alkaline media حسب Dima Abu Alhawa (21768260)

"…Herein, we investigate the fine-tuning of orthorhombic V₂O₅-based electrocatalysts as candidates for HER through a scalable two-step sol–gel calcination procedure. …"

Deciphering the In vitro Role of microRNAs miR-21-3p and miR-222-5p In the Regulation of Clostridioides difficile Flagellin-Induced Inflammation حسب Salman, Zeina

"…Western blot and pathway analyses demonstrated that miR-222-5p and miR-21-3p overexpression increased phosphorylation of p65, a key component of the NF-κB complex, while their knockdown reduced p65 phosphorylation. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

1,2,4-Trimethylbenzene Transformation Reaction Compared With Its Transalkylation Reaction With Toluene Over USY Zeolite حسب Al-Khattaf, H

"…The effect of reaction conditions on the variation of the p-xylene to o-xylene product ratio (P/O), distribution of trimethylbenzene (TMB) isomers (1,3,5-TMB to 1,2,3-TMB), and values of xylene/tetramethylbenzene (X/TeMB) ratios are reported. …"
احصل على النص الكامل

Assessment of High-resolution Local Emissions and Land-use in Air Quality Forecasting at an Urban, Coastal, Desert Environment حسب Christos Fountoukis (4722963)

"…The model’s forecast accuracy was assessed against measurement data from five ground air quality monitoring stations in the greater metropolitan area of Doha over a one-month period. …"

In vitro ischemia suppresses hypoxic induction of hypoxia-inducible factor-1α by inhibition of synthesis and not enhanced degradation حسب Sleiman, Sama F.

"…This study investigated the mechanism by which in vitro ischemia (oxygen-glucose deprivation; OGD) affects canonical hypoxic HIF-1α stabilization. We validated the use of a reporter containing the oxygen-dependent degradation domain of HIF-1α fused to firefly luciferase (ODD-luc) to monitor quantitatively distinct biochemical events leading to hypoxic HIF-1α expression or stabilization in a human neuroblastoma cell line (SH-SY5Y). …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

PD-L1 Expression in Human Breast Cancer Stem Cells Is Epigenetically Regulated through Posttranslational Histone Modifications حسب Pramod Darvin (153341)

"…The active demethylation of PD-L1 promoter was confirmed by the increase in the distribution of 5hmC and decrease in 5mC levels and the upregulation of TET3 and downregulation of DNMTs enzymes in MCF-7 tumorspheres, compared with the cell line. …"

Assessment of tropospheric NO₂ concentrations over greater Doha using Sentinel-5 TROPOspheric monitoring instrument (TROPOMI) satellite data: Temporal analysis, 2018–202... حسب Yasir E. Mohieldeen (22155901)

Role of Active Morphing in the Aerodynamic Performance of Flapping Wings in Formation Flight حسب Billingsley, Ethan

"…Migratory birds have the ability to save energy during flight by arranging themselves in a V-formation. This arrangement enables an increase in the overall efficiency of the group because the wake vortices shed by each of the birds provide additional lift and thrust to every member. …"
احصل على النص الكامل

Review on COVID-19 diagnosis models based on machine learning and deep learning approaches حسب Abu Zitar, Raed

"…COVID-19 is the disease evoked by a new breed of coronavirus called the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). …"
احصل على النص الكامل

Cytotoxicity of [HuArgI (co)-PEG5000]-induced arginine deprivation to ovarian Cancer cells is autophagy dependent حسب Nasreddine, Ghenwa

"…[HuArgI (Co)-PEG5000]-induced arginine deprivation led to extensive and prolonged activation of autophagy, which proved to be deleterious to cell survival since its inhibition led to a significant decrease in cytotoxicity. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Screening for antiretroviral drug resistance among treatment-naive human immunodeficiency virus type 1-infected individuals in Lebanon حسب Mokhbat, Jacques M.

"…Introduction: Antiretroviral therapy (ART) has been successful at decreasing the morbidity and mortality associated with human immunodeficiency virus type 1 (HIV-1) infection. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Experimental investigations on the performance of a thermo-mechanical refrigeration system utilizing ultra-low temperature waste heat sources حسب Ahmad K., Sleiti

"…At a heat source temperature of 85 °C, a condenser water temperature of 15 °C, and an evaporator water temperature of 33 °C, the energy efficiency of the ORC and COP of the VCC are increased to 9.85 % and 3.99, respectively. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Targeting arginine auxotrophy in pancreatic cancer cells using human recombinant arginase I-induced arginine deprivation. (c2017) حسب Khalil, Nathalie

"…This absence of caspase activation was confirmed by a 72 hours cytotoxicity assay on Panc-1 cells, which revealed the failure of the pan-caspase inhibitor, Z-VAD, to reverse or decrease arginine depletion-triggered cell death. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

On the Provisioning of Ultra-Reliable Low-Latency Services in IoT Networks with Multipath Diversity حسب Sweidan, Zahraa

"…The unprecedented increase in the number of smart connected devices invoked a plethora of diverse applications with different performance requirements stipulating various network management strategies. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Quantified Database for Methane Dehydroaromatization Reaction حسب Nagat Elrefaei (21385544)

"…There is an increasing interest in this reaction evident by a large number of literature and patents published so far. …"

Diagnosing type 2 diabetes using Hemoglobin A1c: a systematic review and meta-analysis of the diagnostic cutpoint based on microvascular complications حسب Alexandra E. Butler (6189536)

"…</p><h3>Conclusions</h3><p dir="ltr">The prevalence of nephropathy and moderate retinopathy was increased in subjects with HbA1c values ≥ 6.5% confirming the high specificity of this value for diagnosing T2DM; however, at HbA1c < 6.5% retinopathy increased at age > 55 years and, most strikingly, in African-Americans, suggesting there may be excess microvascular complication prevalence (particularly nephropathy) in individuals below the diabetes diagnostic threshold.…"

Long-Haul Northeast Travel Disrupts Sleep and Induces Perceived Fatigue in Endurance Athletes حسب Christopher J. Stevens (3391547)

"…There was also a likely increase in self-reported fatigue upon waking after the first night in the new destination (1.1 ± 1.6 AU; 0.54; ±0.41) and there were three athletes (25%) who developed symptoms of illness 3–5 days after arrival. …"