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Exploring the epigenetic landscape: The role of 5-hydroxymethylcytosine in neurodevelopmental disorders
Published 2024“…<p dir="ltr">Recent advances in genetic and epigenetic research have underscored the significance of 5-hydroxymethylcytosine (5hmC) in neurodevelopmental disorders (NDDs), such as autism spectrum disorder (ASD) and intellectual disability (ID), revealing its potential as both a biomarker for early detection and a target for novel therapeutic strategies. …”
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C1 neurons excite locus coeruleus and A5 noradrenergic neurons along with sympathetic outflow in rats
Published 2012“…Stimulation of ChR2-expressing neurons at 20 Hz produced modest increasesin LC and A5 neuronal discharge. In additional rats, the retrotrap ezoid nucleus region wasdestroyed with substance P–saporin prior to lentivirus injection into the rostral ventrolateralmedulla, increasing the propor tion of C1 ChR2-expressing neurons (83%). …”
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A Systematic Approach to the Design and Characterization of a Smart Insole for Detecting Vertical Ground Reaction Force (vGRF) in Gait Analysis
Published 2020“…In addition, to evaluate the performance of the different sensors as a component for the smart insole, the acquired vGRF from different insoles were used to compare them. …”
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Complex structural contribution of the morphotropic phase boundary in Na0.5Bi0.5TiO3 - CaTiO3 system
Published 2019“…The correlation between structure and dielectric properties of lead-free (1-x)Na0.5Bi0.5TiO3 - xCaTiO3 ((1-x)NBT - xCT) polycrystalline ceramics was investigated systematically by X-ray diffraction, combined with impedance spectroscopy for dielectric characterizations. …”
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Follow‐Up and Comparative Assessment of SARS‐CoV‐2 IgA, IgG, Neutralizing, and Total Antibody Responses After BNT162b2 or mRNA‐1273 Heterologous Booster Vaccination
Published 2024“…Nevertheless, a heterologous booster led to an increase of ~12 times in the immune response when compared to two consecutive homologous ChAdOx1 immunizations. …”
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Therapeutic targeting of the TPX2/TTK network in colorectal cancer
Published 2023“…<h3>Background</h3><p dir="ltr">While the increased screening, changes in lifestyle, and recent advances in treatment regimen have decreased colorectal cancer (CRC) mortality, metastatic disease and recurrence remains a major clinical challenge. …”
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Abiotic stress applied to Tetraselmis subcordiformis reveals enhanced metabolic responses and increased production of Omega-3 fatty acids: A Metabolomic approach
Published 2024“…Moreover, nitrogen content increase by 20 % and 5.8 % for 100 PSU and N-starvation stress. …”
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The Association of Hypertension with Increased Mortality Rate During the COVID-19 Pandemic: An Update with Meta-analysis
Published 2023“…Pooled results show that the mortality rate of COVID-19 among the included studies ranges from a minimum of 0.39 (95% CI 0.13–1.12) to a maximum of 5.74 (95% CI 3.77–8.74). …”
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Protein arginine methyltransferase 5 (PRMT5) activates WNT/β‐catenin signalling in breast cancer cells via epigenetic silencing of DKK1 and DKK3
Published 2023“…<p></p><div> <p>Protein arginine methyltransferase 5 (PRMT5) activity is dysregulated in many aggressive cancers and its enhanced levels are associated with increased tumour growth and survival. …”
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Sulforaphane Delays Fibroblast Senescence by Curbing Cellular Glucose Uptake, Increased Glycolysis, and Oxidative Damage
Published 2018“…We describe herein that the cruciferous vegetable-derived metabolite, sulforaphane (SFN), activates Nrf2 and delays senescence of human MRC-5 and BJ fibroblasts in vitro. Cell senescence is associated with a progressive and marked increased rate of glucose metabolism through glycolysis. …”
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Flow Simulations of Axisymmetric Prolate Particles in a Cylindrical Pore
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Five-Level MLI-Based Grid-Connected Photovoltaic Systems: A Review on Control Methodologies, Modulation Strategies and Recent Developments
Published 2024“…Five-level MLI-based PV systems have become a crucial option as the relevance of renewable energy keeps increasing because of their increased efficiency, less harmonic distortion, and greater power quality. …”