Metformin attenuates V-domain Ig suppressor of T-cell activation through the aryl hydrocarbon receptor pathway in Melanoma: In Vivo and In Vitro Studies حسب Fawaz E., Alanazi

"…This study aims to investigate the inhibitory effect of metformin on VISTA via AHR in melanoma cells (CHL-1, B16) and animal models. VISTA and AHR levels were assessed by qPCR, Western blot, immunofluorescence microscope, flow cytometry, and immunohistochemistry. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Metformin attenuates V-domain Ig suppressor of T-cell activation through the aryl hydrocarbon receptor pathway in Melanoma: In Vivo and In Vitro Studies حسب Fawaz E., Alanazi

"…This study aims to investigate the inhibitory effect of metformin on VISTA via AHR in melanoma cells (CHL-1, B16) and animal models. VISTA and AHR levels were assessed by qPCR, Western blot, immunofluorescence microscope, flow cytometry, and immunohistochemistry. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Dynamic workload patterns prediction for proactive auto-scaling of web applications حسب Iqbal W.

"…The framework is implemented and experimentally evaluated using historical access logs of three real web applications, each with increasing, decreasing, periodic, and randomly varying arrival rate behaviors. …"
احصل على النص الكامل
احصل على النص الكامل

Decreased soil moisture due to warming drives phylogenetic diversity and community transitions in the tundra حسب Scharn, Ruud

احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Decreased weight gain and enhanced serum biochemical parameters in rats after vitamin D and Ca supplementation حسب Subih H.

احصل على النص الكامل
احصل على النص الكامل

Protein arginine methyltransferase 5 (PRMT5) promotes survival of lymphoma cells via activation of WNT/B-catenin and AKT/GSK3B proliferative signaling حسب Chung, Jihyun

"…We show that PRMT5 stimulates WNT/B-CATENIN signaling through direct epigenetic silencing of pathway antagonists, AXIN2 and WIF1, and indirect activation of AKT/GSK3 signaling.PRMT5 inhibition with either shRNA-mediated knockdown or a specific small molecule PRMT5 inhibitor, CMP-5, not only leads to derepression of WNT antagonists and decreased levels of active phospho-AKT (Thr-450 and Ser-473) and inactive phospho- GSK3B (Ser-9) but also results in decreased transcription of WNT/B-CATENIN target genes, CYCLIN D1, c-MYC, and SURVIVIN, and enhanced lymphoma cell death. …"
احصل على النص الكامل
احصل على النص الكامل

L5 Spinal Nerve Axotomy Induces Distinct Electrophysiological Changes in Axotomized L5- and Adjacent L4-Dorsal Root Ganglion Neurons in Rats . حسب Djouhri, Laiche

"…Here, we recorded somatic action potentials (APs) intracellularly from C- and A-fiber L4/L5 DRG neurons to examine our hypothesis that L5-SNA would induce distinct electrophysiological changes in the two populations of DRG neurons. …"
احصل على النص الكامل
احصل على النص الكامل

TRAINING PRACTICES OF FILIPINO ATHLETES DURING THE EARLY COVID-19 LOCKDOWN حسب Pagaduan, J.C.

احصل على النص الكامل
احصل على النص الكامل

Serum Vitamin D Concentration ≥75 nmol/L Is Related to Decreased Cardiometabolic and Inflammatory Biomarkers, Metabolic Syndrome, and Diabetes; and Increased Cardiorespiratory Fitn... حسب Ganji, Vijay

احصل على النص الكامل
احصل على النص الكامل

A Reconfigurable Multipurpose SoC Mobile Platform for metal detection حسب Al Rshid Abazeed, Omran

"…Zaman, «Efficient design of a metal detector equipped remote-controlled robotic vehicle,» 2016 International Conference on Microelectronics, Computing and Communications (MicroCom), Durgapur, 2016, pp. 1-5 [3] «Cyclone V Device Overview», Altera, 2016. …"
احصل على النص الكامل
احصل على النص الكامل

Ferroelectric Properties and Electrocaloric Effect in Dy2O3 Substitution on Lead-Free (Na0.5 Bi0.5)0.94 Ba0.06TiO3 Ceramic حسب Turki, O.

"…Using the direct EC measurement, the ceramic corresponding to y = 0.02 exhibited a significant EC response, where ΔT = 1.2 K under 5 kV/mm. The incorporation of Dy was found to enhance the EC responsivity coefficient ζ = iT/ΔE), with a best value of ζ = 0.24 K.mm/kV for y = 0.02.…"
احصل على النص الكامل

Investigation of the Effect of Imatinib and Hydroxyurea Combination Therapy on Hematological Parameters and Gene Expression in Chronic Myeloid Leukemia (CML) Patients حسب Al-Amleh, Esraa K.

"…Platelet counts, on the other hand, dramatically decreased in both IM and (HU + IM). (4) Conclusion: Because the studied genes (BCL2, PP2A, CIP2A, and WT1) are participating in cell proliferation and death, the findings show that the examined genes are significant to understand the efficacy of various therapies. …"
احصل على النص الكامل
احصل على النص الكامل

Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes), Supplementation Alters Gut Microbiome and Corrects Dyslipidemia in Rats. حسب Anwar, Haseeb

"…Wistar rats were offered a chow maintenance diet (CMD; CON group) or the same CMD ration with cholesterol (1.5% w/w) and cholic acid (0.5% w/w) added to induce hypercholesterolemia (day 1 to day 24). …"
احصل على النص الكامل
احصل على النص الكامل

Microstructure, wear and corrosion characteristics of Cu matrix reinforced SiC–graphite hybrid composites حسب Jamwal A.

"…Copper matrix composites with SiC-graphite reinforcement (0, 2.5,5, 7.5 and 10 wt.%) were prepared by stir casting process. …"
احصل على النص الكامل
احصل على النص الكامل

Deregulation of cell growth and apoptosis in UV-induced melanomagenesis حسب Ouhtit A.

"…The Bax/Bcl2 ratio increased at higher dose, indicating that the cells had selected apoptosis program. In the wt-p16 melanoma cells, while low UVB dose upregulated p16, the high dose suppressed it, and further abrogated Cdk6 but not Cdk4. …"
احصل على النص الكامل
احصل على النص الكامل

Heme Oxygenase Isoform 1 Regresses Cardiomyocyte Hypertrophy Through Regressing Sodium Proton Exchanger Isoform 1 Activity حسب Sobh, Ahmed

"…Results: Our results showed a significant decrease in HO-1 mRNA expression in cardiomyocytes expressing active NHE1 (74.84 ± 9.19 % vs. 100 % normal NHE1 expression, p<0.05). …"
احصل على النص الكامل
احصل على النص الكامل

Enhancement of mechanical and corrosion resistance properties of electrodeposited NiP-TiC composite coatings حسب Fayyaz O.

"…Various amounts of TiC particles (0, 0.5, 1.0, 1.5, and 2.0 g L−1) were co-electrodeposited in the Ni–P matrix under optimized conditions and then characterized by employing various techniques. …"
احصل على النص الكامل
احصل على النص الكامل

Enhancing thermal and mechanical response of aluminum using nanolength scale TiC ceramic reinforcement حسب Reddy M.P.

"…The CTE of Al composite decreased with the progressive addition of hard TiC nanoparticles. …"
احصل على النص الكامل
احصل على النص الكامل

Combined Noncoding RNA-mRNA Regulomics Signature in Reprogramming and Pluripotency in iPSCs حسب Salloum-Asfar, Salam

احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Tailoring electrocatalytic properties of Pt nanoparticles grown on Ti3C2Tx MXene surface حسب Filip, Jaroslav

"…Composites containing 14 wt% Pt showed HER with an onset potential of −75.9 mV and a current density of −10 mA cm−2 achieved at −226 mV. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل